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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 8452 |
Name | CUL3 |
Synonymous | -;cullin 3;CUL3;cullin 3 |
Definition | CUL-3|cullin-3 |
Position | 2q36.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
CUL3(h) --> CUL3-isoform1(h) (expression). | CUL3(h) + KEAP1(m.s.) <==> CUL3(h):KEAP1(m.s.) (binding) | CUL3(h) + KEAP1(h) <==> CUL3(h):KEAP1(h) (binding) | Nrf2(h) + CUL3(h) + KEAP1(h) <==> Nrf2(h):CUL3(h):KEAP1(h) (binding) | CUL3(h) + RHOBTB2(h) <==> CUL3(h):RHOBTB2(h) (binding) | KLHL22(h) + CUL3(h) <==> KLHL22(h):CUL3(h) (binding) | KLHL13(h) + CUL3(h) <==> KLHL13(h):CUL3(h) (binding) | KLHL9(h) + CUL3(h) <==> KLHL9(h):CUL3(h) (binding) | BTBD2(h) + CUL3(h) <==> BTBD2(h):CUL3(h) (binding) | KLHL12(h) + CUL3(h) <==> KLHL12(h):CUL3(h) (binding) | BTBD1(h) + CUL3(h) <==> BTBD1(h):CUL3(h) (binding) | CUL3(h) + Nedd8(h) --> CUL3(h){nedd} (neddylation) | CUL3(h) + Aurora-B(h) <==> CUL3(h):Aurora-B(h) (binding) | CUL3(h) + Nedd8(m.s.) --Uba3(m.s.),Ubc12(m.s.)--> CUL3(h){nedd} (neddylation) | SPOP(h) + CUL3(h) <==> SPOP(h):CUL3(h) (binding) | CUL3(h) + Daxx(h) <==> CUL3(h):Daxx(h) (binding) | CUL3(h) + SPOP(h) <==> CUL3(h):SPOP(h) (binding) | CUL3(h) --> CUL3(h) (translocation) | CUL3(h) --> PARP-p89(h) (increase of cleavage) | CUL3(h) + Nrf2(h) <==> CUL3(h):Nrf2(h) (binding) | CUL3(h) + Roc1(m.s.) <==> CUL3(h):Roc1(m.s.) (binding) | CUL3(h) --> CUL3(h) (expression). | CUL3(h) --> CUL3(h) (translocation) | Aurora-B(h) + n ubiquitin(h) --CUL3(h)--> Aurora-B(h){ub}n (ubiquitination) | Nrf2(m.s.) + ubiquitin(m.s.) --CUL3(h),KEAP1(m.s.)--> Nrf2(m.s.){ub} (ubiquitination) | Nrf2(m.s.) + ubiquitin(m.s.) --E1(m.s.),Ubc5A(h),CUL3(h),KEAP1(m.s.),Roc1(m.s.)--> Nrf2(m.s.){ub} (ubiquitination) | CUL3(h) --> CUL3-isoform2(h) (expression). | CUL3(h) --> CUL3-isoform3(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
58 | Phosphotyrosine. | Swiss-Prot 53.0 | 737 | Phosphoserine. | Swiss-Prot 53.0 | 712 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in NEDD8) (Bysimilarity). | Swiss-Prot 53.0 | 737 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 58 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr2 |
Promoter: 225157858 - 225159858 | Agilent_014791 |
chr2 |
Promoter: 225157858 - 225159858 | GSE27584 |
chr2 |
Promoter: 225157858 - 225159858 | Agilent_014791_44K |