Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

8550

Name

MAPKAPK5

Synonymous

PRAK;mitogen-activated protein kinase-activated protein kinase 5;MAPKAPK5;mitogen-activated protein kinase-activated protein kinase 5

Definition

MAP kinase-activated protein kinase 5|MAPK-activated protein kinase 5|MAPKAP kinase 5|MAPKAPK-5|p38-regulated/activated protein kinase

Position

12q24.13

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

MAPKAPK5(h) + ATP --p38beta2(h)--> MAPKAPK5(h){p} + ADP (phosphorylation)
MAPKAPK5(h) + ATP --p38delta(m)--> MAPKAPK5(h){p} + ADP (phosphorylation)
p38alpha(m) + MAPKAPK5(h) <==> p38alpha(m):MAPKAPK5(h) (binding)
p38beta1(h) + MAPKAPK5(h) <==> p38beta1(h):MAPKAPK5(h) (binding)
MAPKAPK5(h) --> MAPKAPK5(h) (expression).
Hsp27(m) + ATP --MAPKAPK5(h)--> Hsp27(m){p} + ADP (phosphorylation)
Hsp27(h) + ATP --MAPKAPK5(h)--> Hsp27(h){p} + ADP (phosphorylation)
eIF-4E(m.s.) + ATP --MAPKAPK5(h)--> eIF-4E(m.s.){p} + ADP (phosphorylation)
MAPKAPK5(h) --> MAPKAPK5(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

182Phosphothreonine.Swiss-Prot 53.0
182Phosphothreonine (MAPK1;MAPK14)9628874Phospho.ELM 6.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr12

Promoter: 110763162 - 110765162Agilent_014791

chr12

Promoter: 110763162 - 110765162GSE27584

chr12

Promoter: 110763162 - 110765162GSE27584

chr12

Promoter: 110763162 - 110765162Agilent_014791_44K


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