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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 8626 |
Name | TP63 |
Synonymous | AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L;tumor protein p63;TP63;tumor protein p63 |
Definition | CUSP|amplified in squamous cell carcinoma|chronic ulcerative stomatitis protein|keratinocyte transcription factor KET|transformation-related protein 63|tumor protein 63|tumor protein p53-competing protein|tumor protein p63 deltaN isoform delta |
Position | 3q28 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
Daxx(h) + p63alpha(h) <==> p63alpha(h):Daxx(h) (binding) | p63alpha(h) + hipk2(h) <==> p63alpha(h):hipk2(h) (binding) | p63alpha(h) + hipk2(ha) <==> p63alpha(h):hipk2(ha) (binding) | mdm2(h) + p63alpha(h) <==> mdm2(h):p63alpha(h) (binding) | p63alpha(h) + NF-YB(m) <==> NF-YB(m):p63alpha(h) (binding; interaction) | NF-YC-3(h) + p63alpha(h) <==> NF-YC-3(h):p63alpha(h) (binding; interaction) | p63alpha(h) + RALGPS1(h) <==> p63alpha(h):RALGPS1(h) (binding) | p63alpha(h) + beta-catenin(h) <==> p63alpha(h):beta-catenin(h) (binding) | p63alpha(h) + hnRPAB-3(h) <==> p63alpha(h):hnRPAB-3(h) (binding) | p63alpha(h) + SFRS15(h) <==> p63alpha(h):SFRS15(h) (binding) | Ubc9(h) + p63alpha(h) <==> Ubc9(h):p63alpha(h) (binding) | p63alpha(h) + Ubc9(h) <==> p63alpha(h):Ubc9(h) (binding) | p63alpha(h) + Ubc9(m.s.) <==> p63alpha(h):Ubc9(m.s.) (binding) | sumo1(h) + p63alpha(h) <==> sumo1(h):p63alpha(h) (binding) | p63alpha(h) --> RUNX2(m) (transactivation) | p63alpha(h) --> Bglap2(m) (transactivation) | p63alpha(h) --> Spen(m) (transactivation) | p63alpha(h) --> CASP3(m) (transactivation) | p63alpha(h) --> Ranbp2(m) (transactivation) | p63alpha(h) --/ Elavl2(m) (transrepression) | p63alpha(h) --/ HSF4(m) (transrepression) | TP63(h) --> p63alpha(h) (expression). | Daxx(h) + p63gamma(h) <==> Daxx(h):p63gamma(h) (binding) | p63gamma(h) + hipk2(h) <==> p63gamma(h):hipk2(h) (binding) | p63gamma(h) + hipk2(ha) <==> p63gamma(h):hipk2(ha) (binding) | p63gamma(h) + SSRP1(h) <==> p63gamma(h):SSRP1(h) (binding) | mdm2(h) + p63gamma(h) <==> mdm2(h):p63gamma(h) (binding) | p63gamma(h) --> CDKN1A(h) (transactivation) | p63gamma(h) --> MDM2(h) (transactivation) | p63gamma(h) --> BAX(h) (transactivation) | p63gamma(h) --> SFN(h) (transactivation) | p63gamma(h) --> DDIT4(h) (transactivation) | p63gamma(h) --> JAG1(h) (DNA binding; transactivation). | ASPP1(h) + p63gamma(h) <==> ASPP1(h):p63gamma(h) (binding) | ASPP2(h) + p63gamma(h) <==> ASPP2(h):p63gamma(h) (binding) | TP63(h) --> p63gamma(h) (expression). | 4 p63(h) <==> (p63(h))4 (binding) | p63(h) + p73(h) <==> p63(h):p73(h) (binding) | p63(h) --Caspase(h)--> protein remnants (cleavage) | p63(h) --Caspase-3(m.s.)--> protein remnants (cleavage) | p63(h) --Caspase-6(m.s.)--> protein remnants (cleavage) | p63(h) --Caspase-7(m.s.)--> protein remnants (cleavage) | p63(h) --Caspase-8(m.s.)--> protein remnants (cleavage) | p63(h) --> KRT14(h) (DNA binding). | TP63(h) --> p63(h) (expression). | TP63(h) --> p63beta(h) (expression). | TP63(h) --> DeltaN p63beta(h) (expression). | TP63(h) --> DeltaNp63gamma(h) (expression). | DeltaNp63alpha(h) --> DDIT4(h) (transactivation) | DeltaNp63alpha(h) --/ SFN(h) (DNA binding; transrepression). | DeltaNp63alpha(h) --/ TP63(h) (DNA binding; transrepression). | DeltaNp63alpha(h) --/ CDKN1A(h) (DNA binding; transrepression). | Ubc9(m.s.) + DeltaNp63alpha(h) <==> Ubc9(m.s.):DeltaNp63alpha(h) (binding) | DeltaNp63alpha(h) + sumo1(h) <==> DeltaNp63alpha(h):sumo1(h) (binding) | DeltaNp63alpha(h) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(m.s.)--> DeltaNp63alpha(h){sumo} (sumoylation) | DeltaNp63alpha(h) + sumo1(h) --Ubc9(m.s.)--> DeltaNp63alpha(h){sumoK637} (sumoylation) | DeltaNp63alpha(h) + 2 sumo1(h) --Ubc9(m.s.)--> DeltaNp63alpha(h){sumoK549}{sumoK637} (sumoylation) | DeltaNp63alpha(h) + sumo1(h) --Ubc9(m.s.)--> DeltaNp63alpha(h){sumo} (sumoylation) | itch(h) + DeltaNp63alpha(h) <==> itch(h):DeltaNp63alpha(h) (binding) | TP63(h) --> DeltaNp63alpha(h) (expression). | TP63(h) --> p63delta(h) (expression). | TP63(h) --> p63epsilon(h) (expression). | TP63(h) --> DeltaNp63epsilon(h) (expression). | TP63(h) --> p63(h) (expression). | hsa-miR-203 --/ p63(h) (translational repression). |
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Post Transcriptional Modification From dbPTM | | Top | |
There is no record for TP63 |
Methylation Profile From DiseaseMeth database | | Top | |
There is no record for TP63 |