|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 8841 |
Name | HDAC3 |
Synonymous | HD3|RPD3|RPD3-2;histone deacetylase 3;HDAC3;histone deacetylase 3 |
Definition | SMAP45 |
Position | 5q31 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
|
Regulation From TransFac database |
p53(h) + HDAC3(h) <==> p53(h):HDAC3(h) (binding) | YY1(h) + HDAC3(h) <==> YY1(h):HDAC3(h) (binding) | TGIF(h) + HDAC3(h) <==> TGIF(h):HDAC3(h) (binding). | GATA-2(h) + HDAC3(h) <==> GATA-2(h):HDAC3(h) (binding) | HDAC3(h) + TAB2(m) <==> HDAC3(h):TAB2(m) (binding) | HDAC3(h) + NCOR1(h) + TAB2(h) <==> HDAC3(h):TAB2(h):NCOR1(h) (binding) | HDAC3(h) + MAZ(h) <==> MAZ(h):HDAC3(h) (binding) | HDAC3(h) + MTG16(m) <==> HDAC3(h):MTG16(m) (binding) | HDAC3(h) + SUV39H1(h) <==> HDAC3(h):SUV39H1(h) (binding) | MTG8B(h) + HDAC3(h) <==> MTG8B(h):HDAC3(h) (binding) | Daxx(h) + HDAC3(h) <==> Daxx(h):HDAC3(h) (binding) | HDAC7(h) + HDAC3(h) <==> HDAC7(h):HDAC3(h) (binding) | SMRT(h) + HDAC3(h) <==> SMRT(h):HDAC3(h) (binding) | NCOR1(h) + HDAC3(h) <==> NCOR1(h):HDAC3(h) (binding) | NCOR1-isoform1(m) + HDAC3(h) <==> NCOR1-isoform1(m):HDAC3(h) (binding) | NCOR1(h) + Ebi(h) + HDAC3(h) + Kaiso(h) <==> NCOR1(h):Ebi(h):HDAC3(h):Kaiso(h) (binding) | SMRT(h) + HDAC3(h) + Ebi(h) <==> SMRT(h):HDAC3(h):Ebi(h) (binding) | NCOR1(h) + HDAC3(h) + Ebi(h) <==> NCOR1(h):HDAC3(h):Ebi(h) (binding) | NCOR1(h) + TBLR1(h) + Ebi(h) + HDAC3(h) + Kaiso(h) <==> NCOR1(h):TBLR1(h):Ebi(h):HDAC3(h):Kaiso(h) (binding) | IR10(h) + TIF1g(h) + JMJD2A(h) + GPS2(h) + TRIP-5(h) + TBLR1(h) + Kaiso(h) + NCOR1(h) + HDAC3(h) + Ebi(h) <==> IR10(h):TIF1g(h):JMJD2A(h):GPS2(h):TRIP-5(h):TBLR1(h):Kaiso(h):NCOR1(h):HDAC3(h):Ebi(h) (binding) | Ebi(h) + HDAC3(h) + SMRT(h) <==> Ebi(h):HDAC3(h):SMRT(h) (binding) | SMRT-Alpha(m) + HDAC3(h) <==> SMRT-Alpha(m):HDAC3(h) (binding) | GPS2(h) + HDAC3(h) + NCOR1(h) + TBLR1(h) <==> GPS2(h):HDAC3(h):NCOR1(h):TBLR1(h) (binding) | Ebi(h) + GPS2(h) + HDAC3(h) + NCOR1(h) <==> Ebi(h):GPS2(h):HDAC3(h):NCOR1(h) (binding) | HDAC3(h) --/ ASCL2(h) (transrepression) | HDAC3(h) + GPS2(h) + TBLR1(h) + Ebi(h) + IR10(h) + NCOR1(h) <==> HDAC3(h):GPS2(h):TBLR1(h):Ebi(h):IR10(h):NCOR1(h) (binding) | Ebi(h) + HDAC3(h) + IR10(h) + NCOR1(h) + TBLR1(h) <==> Ebi(h):HDAC3(h):IR10(h):NCOR1(h):TBLR1(h) (binding) | SMRT(h) + GPS2(h) + TBLR1(h) + HDAC3(h) + Ebi(h) <==> SMRT(h):GPS2(h):TBLR1(h):HDAC3(h):Ebi(h) (binding) | HDAC3(h) + NCOR1(h) + Ebi(m.s.) <==> HDAC3(h):NCOR1(h):Ebi(m.s.) (binding) | HDAC3(h) + HDAC4(h) <==> HDAC3(h):HDAC4(h) (binding) | HDAC5(h) + HDAC3(h) <==> HDAC5(h):HDAC3(h) (binding) | HDAC4(h) + HDAC3(h) <==> HDAC4(h):HDAC3(h) (binding) | NCOR1(h) + HDAC3(h) + HDAC4(h) <==> NCOR1(h):HDAC3(h):HDAC4(h) (binding) | SMRT(h) + HDAC3(h) + HDAC4(h) <==> SMRT(h):HDAC3(h):HDAC4(h) (binding) | Ebi(h) + GPS2(h) + HDAC3(h) + NCOR1(h) + TBLR1(h) <==> Ebi(h):GPS2(h):HDAC3(h):NCOR1(h):TBLR1(h) (binding) | OGG1-1A(h) + HDAC3(h) <==> OGG1-1A(h):HDAC3(h) (binding) | HDAC3(h) --Caspase(h)--> protein remnants (cleavage) | HDAC3(h) --> HDAC3(h) (translocation) | GPS2(h) + HDAC3(h) <==> GPS2(h):HDAC3(h) (binding) | SHP(h) + HDAC3(h) <==> SHP(h):HDAC3(h) (binding) | HDAC3(h) + IL-16(m.s.) <==> HDAC3(h):IL-16(m.s.) (binding) | HDAC3(h) + IL16(h) <==> HDAC3(h):IL16(h) (binding) | HDAC3(h) + ATP --CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2--> HDAC3(h){p} + ADP (phosphorylation) | HDAC3(h) + IkappaB-alpha(h) <==> HDAC3(h):IkappaB-alpha(h) (binding) | HDAC3(h) + pRb(h) <==> HDAC3(h):pRb(h) (binding) | p107(h) + HDAC3(h) <==> p107(h):HDAC3(h) (binding) | HDAC3(h) + pRb(m.s.) <==> HDAC3(h):pRb(m.s.) (binding) | HDAC3(h) + RBBP1(m.s.) <==> RBBP1(m.s.):HDAC3(h) (binding) | RBBP1(h) + HDAC3(h) <==> RBBP1(h):HDAC3(h) (binding) | HDAC3(h) + BCOR-isoform2(h) <==> HDAC3(h):BCOR-isoform2(h) (binding) | HDAC3(h) + BCOR-S(h) <==> HDAC3(h):BCOR-S(h) (binding) | HDAC3(h) + HDAC1(m) <==> HDAC3(h):HDAC1(m) (binding) | HDAC3(h) + HDAC9-7(h) <==> HDAC3(h):HDAC9-7(h) (binding) | HDAC3(h) + PML-X(h) <==> HDAC3(h):PML-X(h) (binding) | TFII-I(h) + HDAC3(h) <==> TFII-I(h):HDAC3(h) (binding) | HDAC3(h) + GATA-1(m) <==> HDAC3(h):GATA-1(m) (binding) | Tbx3(h) + HDAC3(h) <==> Tbx3(h):HDAC3(h) (binding) | Hsp70-1(h) + HDAC3(h) <==> Hsp70-1(h):HDAC3(h) (binding) | HDAC3(h) + SF3b1(h) <==> HDAC3(h):SF3b1(h) (binding) | HDAC3(h) --/ LSS(h) (transrepression) | HDAC3(h) --> HMGCS2(h) (transactivation) | HDAC3(h) --> HMGCR(h) (transactivation) | HDAC3(h) --> MVK(h) (transactivation) | HDAC3(h) --> PMVK(h) (transactivation) | HDAC3(h) --> MVD(h) (transactivation) | HDAC3(h) --> Fdps(h) (transactivation) | HDAC3(h) --> FDFT1(h) (transactivation) | HDAC3(h) --> SQLE(h) (transactivation) | HDAC3(h) --> DHCR7(h) (transactivation) | HDAC3(h) --> CCND1(h) (DNA binding). | HDAC3(h) --> HDAC3(h) (expression). | HDAC4(h) --/ HDAC3(h) (decrease of abundance) | HDAC3(h) --> HDAC3(h) (translocation) | histone H3(h){aceK10}{aceK15}{aceK19} --HDAC3(h)--> histone H3(h) + 3 acetyl (deacetylation) | histone H4(h){aceK6}{aceK9}{aceK13}{aceK17} --HDAC3(h)--> histone H4(h) + 4 acetyl (deacetylation) | histone H2B(h){aceK12}{aceK15} --HDAC3(h)--> histone H2B(h) + 2 acetyl (deacetylation) | histone H2A(h){aceK6} --HDAC3(h)--> histone H2A(h) + acetyl (deacetylation) | histone H4(h){aceK6}{aceK9}{aceK17} --HDAC3(h)--> histone H4(h) + 3 acetyl (deacetylation) | T3R-beta1(h) + cyclinD1(m.s.) + HDAC3-isoform1(h) <==> T3R-beta1(h):cyclinD1(m.s.):HDAC3-isoform1(h) (binding) | cyclinD1(m.s.) + HDAC3-isoform1(h) <==> cyclinD1(m.s.):HDAC3-isoform1(h) (binding) | HDAC3(h) --> HDAC3-isoform1(h) (expression). | HDAC3(h) --> HDAC3-isoform2(h) (expression). |
|---|
Post Transcriptional Modification From dbPTM | | Top | |
|
Location (AA) |
PTM type |
Literature |
Database |
424 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|
Methylation Profile From DiseaseMeth database | | Top | |
|
Chromosome |
Location |
Source |
|---|---|---|
chr5 |
Promoter: 140996096 - 140998096 | GSE27584 |
chr5 |
Promoter: 140996096 - 140998096 | Agilent_014791_44K |
chr5 |
Promoter: 140996096 - 140998096 | Agilent_014791 |