Entrez Gene

Basic Information
Gene ID	1959
Name	EGR2
Synonymous	AT591\|CMT1D\|CMT4E\|KROX20;early growth response 2;EGR2;early growth response 2
Definition	E3 SUMO-protein ligase EGR2\|EGR-2\|KROX-20, Drosophila, homolog (early growth response-2)\|Krox-20 homolog, Drosophila\|early growth response protein 2\|zinc finger protein Krox-20
Position	10q21.1
Gene type	protein-coding
Source	Count: 1; Generif
Sentence	Abstract
overexpression of miR-150 in gastric cancer could promote proliferation and growth of cancer cells at least partially through directly targeting the tumor-suppressor EGR2.	Accumulating evidence suggests small non-coding RNAs (microRNAs) play important roles in human cancer progression. In the present study, we found miR-150 was overexpressed in gastric cancer cell lines and tissues. Ectopic expression of miR-150 promoted tumorigenesis and proliferation of gastric cancer cells. Luciferase reporter assay demonstrated that EGR2 was a direct target of miR-150. Collectively, our study demonstrated that overexpression of miR-150 in gastric cancer could promote proliferation and growth of cancer cells at least partially through directly targeting the tumor-suppressor EGR2, suggesting a potential strategy for the development of miRNA-based treatment of gastric cancer.