Entrez Gene

General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	23410
Name	SIRT3
Synonymous	SIR2L3;sirtuin 3;SIRT3;sirtuin 3
Definition	NAD-dependent deacetylase sirtuin-3, mitochondrial\|SIR2-like protein 3\|mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase\|silent mating type information regulation 2, S.cerevisiae, homolog 3\|sir2-like 3\|sirtuin type 3
Position	11p15.5
Gene type	protein-coding
Source	Count: 1; Generif
Sentence	Abstract
"These results identify SIRT3 as a genomically expressed, mitochondria-localized tumor suppressor."	The sirtuin gene family (SIRT) is hypothesized to regulate the aging process and play a role in cellular repair. This work demonstrates that SIRT3(-/-) mouse embryonic fibroblasts (MEFs) exhibit abnormal mitochondrial physiology as well as increases in stress-induced superoxide levels and genomic instability. expression of a single oncogene (Myc or Ras) in SIRT3(-/-) MEFs results in in vitro transformation and altered intracellular metabolism. Superoxide dismutase prevents transformation by a single oncogene in SIRT3(-/-) MEFs and reverses the tumor-permissive phenotype as well as stress-induced genomic instability. In addition, SIRT3(-/-) mice develop ER/PR-positive mammary tumors. Finally, human breast and other human cancer specimens exhibit reduced SIRT3 levels. These results identify SIRT3 as a genomically expressed, mitochondria-localized tumor suppressor.CI - Copyright (c) 2010 Elsevier Inc. All rights reserved.
"These results identify SIRT3 as a genomically expressed, mitochondria-localized tumor suppressor."	The sirtuin gene family (SIRT) is hypothesized to regulate the aging process and play a role in cellular repair. This work demonstrates that SIRT3(-/-) mouse embryonic fibroblasts (MEFs) exhibit abnormal mitochondrial physiology as well as increases in stress-induced superoxide levels and genomic instability. expression of a single oncogene (Myc or Ras) in SIRT3(-/-) MEFs results in in vitro transformation and altered intracellular metabolism. Superoxide dismutase prevents transformation by a single oncogene in SIRT3(-/-) MEFs and reverses the tumor-permissive phenotype as well as stress-induced genomic instability. In addition, SIRT3(-/-) mice develop ER/PR-positive mammary tumors. Finally, human breast and other human cancer specimens exhibit reduced SIRT3 levels. These results identify SIRT3 as a genomically expressed, mitochondria-localized tumor suppressor.CI - Copyright (c) 2010 Elsevier Inc. All rights reserved.