Entrez Gene

General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	5047
Name	PAEP
Synonymous	GD\|GdA\|GdF\|GdS\|PAEG\|PEP\|PP14;progestagen-associated endometrial protein;PAEP;progestagen-associated endometrial protein
Definition	PEG\|PP14 protein (placental protein 14)\|alpha uterine protein\|glycodelin\|glycodelin-A\|glycodelin-F\|glycodelin-S\|placental protein 14\|pregnancy-associated endometrial alpha-2 globulin\|pregnancy-associated endometrial alpha-2-globulin\|progestagen-associated
Position	9q34
Gene type	protein-coding
Source	Count: 1; Generif
Sentence	Abstract
Glycodelin-induced differentiation was associated with reduced expression of oncogenes and increased expression of tumor suppressor genes. Our results suggest that glycodelin acts as a tumor suppressor in breast cancer	Malignant growth is characterized by loss of cell differentiation, uncontrolled proliferation and resistance to apoptosis. Many tumor suppressor genes that protect cells against malignant transformation regulate cell differentiation. Here, we show for the first time that glycodelin, a differentiation-related protein, reduces breast cancer tumor growth in vivo. We found that glycodelin cDNA-transfected MCF-7 breast cancer cells showed a differentiated phenotype and produced smaller tumors in mouse mammary fat pads compared with control-transfected cells. Glycodelin-induced differentiation was associated with reduced expression of oncogenes and increased expression of tumor suppressor genes. Our results suggest that glycodelin acts as a tumor suppressor in breast cancer. This may explain its reported association with a more favorable prognosis in some cancers.CI - (c) 2008 Wiley-Liss, Inc.