|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 5310 |
Name | PKD1 |
Synonymous | PBP|Pc-1|TRPP1;polycystic kidney disease 1 (autosomal dominant);PKD1;polycystic kidney disease 1 (autosomal dominant) |
Definition | autosomal dominant polycystic kidney disease 1 protein|polycystic kidney disease-associated protein|polycystin 1|polycystin-1|transient receptor potential cation channel, subfamily P, member 1 |
Position | 16p13.3 |
Gene type | protein-coding |
Source | Count: 1; Generif |
|
Sentence |
Abstract |
| Data suggest that PKD1 may act as a novel member of the tumor suppressor family of genes. | The approximately 14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a large ( approximately 460 kDa) protein, termed polycystin-1 (PC-1), that is responsible for autosomal dominant polycystic kidney disease (ADPKD). The unique organization of its multiple adhesive domains (16 Ig-like domains/PKD domains) suggests that it may play an important role in cell-cell/cell-matrix interactions. Here we demonstrated that PKD1 promoted cell-cell and cell-matrix interactions in cancer cells, indicating that PC-1 is involved in the cell adhesion process. Furthermore in this study, we showed that PKD1 inhibited cancer cells migration and invasion. And we also showed that PC-1 regulated these processes in a process that may be at least partially through the Wnt pathway. Collectively, our data suggest that PKD1 may act as a novel member of the tumor suppressor family of genes.CI - Copyright (c) 2007 John Wiley & Sons, Ltd. |
|
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston Rights Reserved |