Entrez Gene

General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	56940
Name	DUSP22
Synonymous	JKAP\|JSP1\|LMWDSP2\|MKPX\|VHX;dual specificity phosphatase 22;DUSP22;dual specificity phosphatase 22
Definition	JNK-stimulating phosphatase 1\|JNK-stimulatory phosphatase-1\|JSP-1\|LMW-DSP2\|MAP kinase phosphatase x\|MKP-x\|dual specificity protein phosphatase 22\|homolog of mouse dual specificity phosphatase LMW-DSP2\|low molecular weight dual specificity phosphatase 2\|mi
Position	6p25.3
Gene type	protein-coding
Source	Count: 2; TAG,Generif
Sentence	Abstract
"This recurrent t(6;7)(p25.3;q32.3) entails a downregulation of DUSP22 and an overexpression of MIR29, leading to postulate that the first (DUSP22) might function as a tumour suppressor and the second (MIR29) as an oncogene in translocated ALK- ALCLs."	Peripheral T-cell lymphomas (PTCLs) are heterogeneous and uncommon malignancies characterized by an aggressive clinical course and a mostly poor outcome with current treatment strategies. The recent genome-wide molecular characterization of several entities has provided novel insights into their pathobiology and led to the identification of new biomarkers with diagnostic, prognostic or therapeutic implications for PTCL patients. Cell lineage and differentiation antigens (markers of gammadelta or NK lineage, of cytotoxicity, of follicular helper T cells) reflect the tumour's biological behaviour, and their detection in tissue samples may refine the diagnostic and prognostic stratification of the patients. Previously unrecognized gene rearrangements are being discovered (ITK-SYK translocation, IRF4/MUM1 and DUSP22 rearrangements), and may serve as diagnostic genetic markers. Deregulated molecules within oncogenic pathways (NF-kappaB, Syk, PDGFRalpha) and immunoreactive cell-surface antigens (CD30, CD52) have been brought to the fore as potential targets for guiding the development of novel therapies.CI - Copyright A(c) 2012 Elsevier Ltd. All rights reserved.