| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10013130 | HBV | ENSG00000136869.16 | protein_coding | TLR4 | No | No | 7099 | O00206 |
| TVIS44026182 | HTLV-1 | ENSG00000136869.16 | protein_coding | TLR4 | No | No | 7099 | O00206 |
| TVIS44026183 | HTLV-1 | ENSG00000136869.16 | protein_coding | TLR4 | No | No | 7099 | O00206 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TLR4 |
|---|---|
| DrugBank ID | DB00924 |
| Drug Name | Cyclobenzaprine |
| Target ID | BE0002442 |
| UniProt ID | O00206 |
| Regulation Type | inhibitor |
| PubMed IDs | 20381591; 21975349 |
| Citations | Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, Phipps S, Foster PS, Landgraf K, Falke JJ, Rice KC, Maier SF, Yin H, Watkins LR: Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience. 2010 Jun 30;168(2):551-63. doi: 10.1016/j.neuroscience.2010.03.067. Epub 2010 Apr 8.@@Mestres J, Seifert SA, Oprea TI: Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome. Clin Pharmacol Ther. 2011 Nov;90(5):662-5. doi: 10.1038/clpt.2011.177. Epub 2011 Oct 5. |
| Groups | Approved |
| Direct Classification | Dibenzocycloheptenes |
| SMILES | CN(C)CCC=C1C2=CC=CC=C2C=CC2=CC=CC=C12 |
| Pathways | |
| PharmGKB | PA449160 |
| ChEMBL | CHEMBL669 |
