| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10013130 | HBV | ENSG00000136869.16 | protein_coding | TLR4 | No | No | 7099 | O00206 |
| TVIS44026182 | HTLV-1 | ENSG00000136869.16 | protein_coding | TLR4 | No | No | 7099 | O00206 |
| TVIS44026183 | HTLV-1 | ENSG00000136869.16 | protein_coding | TLR4 | No | No | 7099 | O00206 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | TLR4 |
|---|---|
| DrugBank ID | DB01183 |
| Drug Name | Naloxone |
| Target ID | BE0002442 |
| UniProt ID | O00206 |
| Regulation Type | inhibitor |
| PubMed IDs | 22520687 |
| Citations | Lewis SS, Loram LC, Hutchinson MR, Li CM, Zhang Y, Maier SF, Huang Y, Rice KC, Watkins LR: (+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats. J Pain. 2012 May;13(5):498-506. doi: 10.1016/j.jpain.2012.02.005. Epub 2012 Apr 20. |
| Groups | Approved; Vet_approved |
| Direct Classification | Phenanthrenes and derivatives |
| SMILES | OC1=CC=C2C[C@H]3N(CC=C)CC[C@@]45[C@@H](OC1=C24)C(=O)CC[C@@]35O |
| Pathways | Naloxone Action Pathway |
| PharmGKB | PA450586 |
| ChEMBL | CHEMBL80 |
