| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10013130 | HBV | ENSG00000136869.16 | protein_coding | TLR4 | No | No | 7099 | O00206 |
| TVIS44026182 | HTLV-1 | ENSG00000136869.16 | protein_coding | TLR4 | No | No | 7099 | O00206 |
| TVIS44026183 | HTLV-1 | ENSG00000136869.16 | protein_coding | TLR4 | No | No | 7099 | O00206 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TLR4 |
|---|---|
| DrugBank ID | DB04933 |
| Drug Name | Eritoran |
| Target ID | BE0002442 |
| UniProt ID | O00206 |
| Regulation Type | |
| PubMed IDs | 17803912; 16820585 |
| Citations | Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, Lee JO: Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell. 2007 Sep 7;130(5):906-17.@@Shimamoto A, Chong AJ, Yada M, Shomura S, Takayama H, Fleisig AJ, Agnew ML, Hampton CR, Rothnie CL, Spring DJ, Pohlman TH, Shimpo H, Verrier ED: Inhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury. Circulation. 2006 Jul 4;114(1 Suppl):I270-4. |
| Groups | Investigational |
| Direct Classification | Acylaminosugars |
| SMILES | CCCCCCCCCCCC(=O)CC(=O)N[C@H]1[C@@H](OP(O)(O)=O)O[C@H](CO[C@@H]2O[C@H](COC)[C@@H](OP(O)(O)=O)[C@H](OCC[C@@H](CCCCCCC)OC)[C@H]2NC(=O)CCCCCCCCCC=C/CCCCCC)[C@@H](O)[C@@H]1OCCCCCCCCCC |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL501259 |
