| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10014326 | HBV | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
| TVIS30086512 | HIV | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
| TVIS20022380 | HPV | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
| TVIS20049966 | HPV | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
| TVIS20049934 | HPV | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
| TVIS44013458 | HTLV-1 | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
| TVIS44020347 | HTLV-1 | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PGR |
|---|---|
| DrugBank ID | DB00834 |
| Drug Name | Mifepristone |
| Target ID | BE0000557 |
| UniProt ID | P06401 |
| Regulation Type | antagonist |
| PubMed IDs | 10374120; 10682471; 10699595; 10806733; 11783365; 11752352 |
| Citations | Greb RR, Kiesel L, Selbmann AK, Wehrmann M, Hodgen GD, Goodman AL, Wallwiener D: Disparate actions of mifepristone (RU 486) on glands and stroma in the primate endometrium. Hum Reprod. 1999 Jan;14(1):198-206.@@Sun M, Zhu G, Zhou L: [Effect of mifepristone on the expression of progesterone receptor messenger RNA and protein in uterine leiomyomata]. Zhonghua Fu Chan Ke Za Zhi. 1998 Apr;33(4):227-31.@@Hazra BG, Basu S, Pore VS, Joshi PL, Pal D, Chakrabarti P: Synthesis of 11beta-(4-dimethylaminophenyl)-17beta-hydroxy-17alpha- (3-methyl-1-butynyl)-4, 9-estradien-3-one and 11beta-(4-acetophenyl)- 17beta-hydroxy-17alpha-(3-methyl-1-butynyl)-4, 9-estradien-3-one: two new analogs of mifepristone (RU-486). Steroids. 2000 Mar;65(3):157-62.@@Gao Y, Cheng L, Liu Y: [Failure of mifepristone induced interruption of pregnancy: point mutation at genetic codon 722 in human progesterone receptor gene]. Zhonghua Fu Chan Ke Za Zhi. 1998 Sep;33(9):549-52.@@Jiang J, Wu R, Wang Z: [Effects of mifepristone on expression of estrogen receptor and progesterone receptor in cultured human eutopic and ectopic endometria]. Zhonghua Fu Chan Ke Za Zhi. 2001 Apr;36(4):218-21.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | Oxosteroids |
| SMILES | [H][C@@]12CC[C@@](O)(C#CC)[C@@]1(C)C[C@H](C1=CC=C(C=C1)N(C)C)C1=C3CCC(=O)C=C3CC[C@@]21[H] |
| Pathways | |
| PharmGKB | PA450500 |
| ChEMBL | CHEMBL1276308 |
