| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10014326 | HBV | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
| TVIS30086512 | HIV | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
| TVIS20022380 | HPV | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
| TVIS20049966 | HPV | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
| TVIS20049934 | HPV | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
| TVIS44013458 | HTLV-1 | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
| TVIS44020347 | HTLV-1 | ENSG00000082175.16 | protein_coding | PGR | Yes | No | 5241 | P06401 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PGR |
|---|---|
| DrugBank ID | DB00957 |
| Drug Name | Norgestimate |
| Target ID | BE0000557 |
| UniProt ID | P06401 |
| Regulation Type | agonist |
| PubMed IDs | 1324557; 17107221; 7750291; 8384965; 11752352 |
| Citations | London RS, Chapdelaine A, Upmalis D, Olson W, Smith J: Comparative contraceptive efficacy and mechanism of action of the norgestimate-containing triphasic oral contraceptive. Acta Obstet Gynecol Scand Suppl. 1992;156:9-14.@@Graziottin A: A review of transdermal hormonal contraception : focus on the ethinylestradiol/norelgestromin contraceptive patch. Treat Endocrinol. 2006;5(6):359-65.@@Kuhnz W, Fritzemeier KH, Hegele-Hartung C, Krattenmacher R: Comparative progestational activity of norgestimate, levonorgestrel-oxime and levonorgestrel in the rat and binding of these compounds to the progesterone receptor. Contraception. 1995 Feb;51(2):131-9.@@Juchem M, Pollow K, Elger W, Hoffmann G, Mobus V: Receptor binding of norgestimate--a new orally active synthetic progestational compound. Contraception. 1993 Mar;47(3):283-94.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | Steroid esters |
| SMILES | [H][C@@]12CC[C@@](OC(C)=O)(C#C)[C@@]1(CC)CC[C@]1([H])[C@@]3([H])CCC(C=C3CC[C@@]21[H])=N/O |
| Pathways | |
| PharmGKB | PA164744346 |
| ChEMBL | CHEMBL1200934 |
