| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10008450 | HBV | ENSG00000175344.19 | protein_coding | CHRNA7 | No | No | 1139 | P36544 |
| TVIS10034714 | HBV | ENSG00000175344.19 | protein_coding | CHRNA7 | No | No | 1139 | P36544 |
| TVIS20027526 | HPV | ENSG00000175344.19 | protein_coding | CHRNA7 | No | No | 1139 | P36544 |
| TVIS44009999 | HTLV-1 | ENSG00000175344.19 | protein_coding | CHRNA7 | No | No | 1139 | P36544 |
| TVIS44012786 | HTLV-1 | ENSG00000175344.19 | protein_coding | CHRNA7 | No | No | 1139 | P36544 |
| TVIS44033742 | HTLV-1 | ENSG00000175344.19 | protein_coding | CHRNA7 | No | No | 1139 | P36544 |
| TVIS44000630 | HTLV-1 | ENSG00000175344.19 | protein_coding | CHRNA7 | No | No | 1139 | P36544 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CHRNA7 |
|---|---|
| DrugBank ID | DB00184 |
| Drug Name | Nicotine |
| Target ID | BE0002341 |
| UniProt ID | P36544 |
| Regulation Type | agonist |
| PubMed IDs | 17360707; 16754836; 19560048; 11006350; 20400469; 20081230 |
| Citations | Mexal S, Jenkins PM, Lautner MA, Iacob E, Crouch EL, Stitzel JA: alpha7 nicotinic receptor gene promoter polymorphisms in inbred mice affect expression in a cell type-specific fashion. J Biol Chem. 2007 May 4;282(18):13220-7. Epub 2007 Mar 14.@@Olincy A, Harris JG, Johnson LL, Pender V, Kongs S, Allensworth D, Ellis J, Zerbe GO, Leonard S, Stevens KE, Stevens JO, Martin L, Adler LE, Soti F, Kem WR, Freedman R: Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. Arch Gen Psychiatry. 2006 Jun;63(6):630-8.@@Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. doi: 10.1016/j.semcdb.2009.01.007. Epub 2009 Jan 22.@@Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202.@@Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. doi: 10.1124/jpet.110.165738. Epub 2010 Apr 16.@@Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. |
| Groups | Approved |
| Direct Classification | Pyrrolidinylpyridines |
| SMILES | CN1CCC[C@H]1C1=CN=CC=C1 |
| Pathways | Nicotine Action Pathway; Nicotine Metabolism Pathway |
| PharmGKB | PA450626 |
| ChEMBL | CHEMBL3 |
