| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20054561 | HPV | ENSG00000144285.24 | protein_coding | SCN1A | No | No | 6323 | P35498 |
| TVIS44014625 | HTLV-1 | ENSG00000144285.24 | protein_coding | SCN1A | No | No | 6323 | P35498 |
| TVIS44009369 | HTLV-1 | ENSG00000144285.24 | protein_coding | SCN1A | No | No | 6323 | P35498 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SCN1A |
|---|---|
| DrugBank ID | DB00252 |
| Drug Name | Phenytoin |
| Target ID | BE0000141 |
| UniProt ID | P35498 |
| Regulation Type | inhibitor |
| PubMed IDs | 15805193; 17001291; 20298965 |
| Citations | Tate SK, Depondt C, Sisodiya SM, Cavalleri GL, Schorge S, Soranzo N, Thom M, Sen A, Shorvon SD, Sander JW, Wood NW, Goldstein DB: Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5507-12. Epub 2005 Apr 1.@@Tate SK, Singh R, Hung CC, Tai JJ, Depondt C, Cavalleri GL, Sisodiya SM, Goldstein DB, Liou HH: A common polymorphism in the SCN1A gene associates with phenytoin serum levels at maintenance dose. Pharmacogenet Genomics. 2006 Oct;16(10):721-6.@@Mantegazza M, Curia G, Biagini G, Ragsdale DS, Avoli M: Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol. 2010 Apr;9(4):413-24. doi: 10.1016/S1474-4422(10)70059-4. |
| Groups | Approved; Vet_approved |
| Direct Classification | Phenylhydantoins |
| SMILES | O=C1NC(=O)C(N1)(C1=CC=CC=C1)C1=CC=CC=C1 |
| Pathways | Fosphenytoin (Antiarrhythmic) Action Pathway; Fosphenytoin (Antiarrhythmic) Metabolism Pathway; Phenytoin (Antiarrhythmic) Action Pathway |
| PharmGKB | PA450947 |
| ChEMBL | CHEMBL16 |
