| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20054561 | HPV | ENSG00000144285.24 | protein_coding | SCN1A | No | No | 6323 | P35498 |
| TVIS44014625 | HTLV-1 | ENSG00000144285.24 | protein_coding | SCN1A | No | No | 6323 | P35498 |
| TVIS44009369 | HTLV-1 | ENSG00000144285.24 | protein_coding | SCN1A | No | No | 6323 | P35498 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SCN1A |
|---|---|
| DrugBank ID | DB00564 |
| Drug Name | Carbamazepine |
| Target ID | BE0009738 |
| UniProt ID | Q15858 |
| Regulation Type | inhibitor |
| PubMed IDs | 20526191; 12391287; 20643904; 15208697 |
| Citations | Yang YC, Huang CS, Kuo CC: Lidocaine, carbamazepine, and imipramine have partially overlapping binding sites and additive inhibitory effect on neuronal Na+ channels. Anesthesiology. 2010 Jul;113(1):160-74. doi: 10.1097/ALN.0b013e3181dc1dd6.@@Yang YC, Kuo CC: Inhibition of Na(+) current by imipramine and related compounds: different binding kinetics as an inactivation stabilizer and as an open channel blocker. Mol Pharmacol. 2002 Nov;62(5):1228-37.@@Lipkind GM, Fozzard HA: Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore. Mol Pharmacol. 2010 Oct;78(4):631-8. doi: 10.1124/mol.110.064683. Epub 2010 Jul 19.@@Rogawski MA, Loscher W: The neurobiology of antiepileptic drugs. Nat Rev Neurosci. 2004 Jul;5(7):553-64. doi: 10.1038/nrn1430. |
| Groups | Approved; Investigational |
| Direct Classification | Dibenzazepines |
| SMILES | NC(=O)N1C2=CC=CC=C2C=CC2=CC=CC=C12 |
| Pathways | Carbamazepine Metabolism Pathway |
| PharmGKB | PA448785 |
| ChEMBL | CHEMBL108 |
