Target Gene Table ▼
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS30085618HIVENSG00000007171.19protein_codingNOS2NoNo4843P35228
TVIS44042313HTLV-1ENSG00000007171.19protein_codingNOS2NoNo4843P35228
TVIS44042312HTLV-1ENSG00000007171.19protein_codingNOS2NoNo4843P35228
TCGA Plot Options ▼
Drug Information ▼
GeneNOS2
DrugBank IDDB05383
Drug NamePimagedine
Target IDBE0000005
UniProt IDP35228
Regulation Typeinhibitor
PubMed IDs17139284; 17016423; 10592235; 11752352; 11095919; 20199223; 20224425; 9715714; 28101475; 15039329; 16469770; 11803948; 25191931; 21277116; 34584641; 30620717; 22135691; 11182788; 18782627; 7515129; 29435886; 29109744; 22912853
CitationsOverington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Valente E, Assis MC, Alvim IM, Pereira GM, Plotkowski MC: Pseudomonas aeruginosa induces apoptosis in human endothelial cells. Microb Pathog. 2000 Dec;29(6):345-56. doi: 10.1006/mpat.2000.0400.@@Tomita M, Maeda M, Maezawa H, Usami N, Kobayashi K: Bystander cell killing in normal human fibroblasts is induced by synchrotron X-ray microbeams. Radiat Res. 2010 Mar;173(3):380-5. doi: 10.1667/RR1995.1.@@Draisma A, Dorresteijn MJ, Bouw MP, van der Hoeven JG, Pickkers P: The role of cytokines and inducible nitric oxide synthase in endotoxemia-induced endothelial dysfunction. J Cardiovasc Pharmacol. 2010 Jun;55(6):595-600. doi: 10.1097/FJC.0b013e3181da774b.@@Tassiopoulos AK, Hakim TS, Finck CM, Pedoto A, Hodell MG, Landas SK, McGraw DJ: Neutrophil sequestration in the lung following acute aortic occlusion starts during ischaemia and can be attenuated by tumour necrosis factor and nitric oxide blockade. Eur J Vasc Endovasc Surg. 1998 Jul;16(1):36-42. doi: 10.1016/s1078-5884(98)80089-0.@@Eslami SM, Moradi MM, Ghasemi M, Dehpour AR: Anticonvulsive Effects of Licofelone on Status Epilepticus Induced by Lithium-pilocarpine in Wistar Rats: a Role for Inducible Nitric Oxide Synthase. J Epilepsy Res. 2016 Dec 31;6(2):51-58. doi: 10.14581/jer.16011. eCollection 2016 Dec.@@Zamboni DS, Rabinovitch M: Phagocytosis of apoptotic cells increases the susceptibility of macrophages to infection with Coxiella burnetii phase II through down-modulation of nitric oxide production. Infect Immun. 2004 Apr;72(4):2075-80. doi: 10.1128/IAI.72.4.2075-2080.2004.@@Vera Y, Erkkila K, Wang C, Nunez C, Kyttanen S, Lue Y, Dunkel L, Swerdloff RS, Sinha Hikim AP: Involvement of p38 mitogen-activated protein kinase and inducible nitric oxide synthase in apoptotic signaling of murine and human male germ cells after hormone deprivation. Mol Endocrinol. 2006 Jul;20(7):1597-609. doi: 10.1210/me.2005-0395. Epub 2006 Feb 9.@@Saarinen M, Ekman P, He Q, Ikeda M, Virtala M, Yu DTY, Arvilommi H, Granfors K: Elimination of Salmonella enterica serotype enteritidis in intestinal epithelial cells by mechanisms other than nitric oxide. J Med Microbiol. 2002 Jan;51(1):13-19. doi: 10.1099/0022-1317-51-1-13.@@Wang J, Kalhor A, Lu S, Crawford R, Ni JD, Xiao Y: iNOS expression and osteocyte apoptosis in idiopathic, non-traumatic osteonecrosis. Acta Orthop. 2015 Feb;86(1):134-41. doi: 10.3109/17453674.2014.960997. Epub 2014 Sep 5.@@Butterworth KT, McGarry CK, Trainor C, O'Sullivan JM, Hounsell AR, Prise KM: Out-of-field cell survival following exposure to intensity-modulated radiation fields. Int J Radiat Oncol Biol Phys. 2011 Apr 1;79(5):1516-22. doi: 10.1016/j.ijrobp.2010.11.034. Epub 2011 Jan 27.@@Farhad AR, Razavi F, Razavi SM, Saatchi M, Manshaei M: Histological assessment of the local effect of different concentrations of aminoguanidine hydrochloride on bone healing in rats. Dent Res J (Isfahan). 2021 Aug 18;18:63. eCollection 2021.@@Scalise ML, Amaral MM, Reppetti J, Damiano AE, Ibarra C, Sacerdoti F: Cytotoxic effects of Shiga toxin-2 on human extravillous trophoblast cell lines. Reproduction. 2019 Mar;157(3):297-304. doi: 10.1530/REP-18-0581.@@Farhad AR, Razavi SM, Nejad PA: The use of aminoguanidine, a selective inducible nitric oxide synthase inhibitor, to evaluate the role of nitric oxide on periapical healing. Dent Res J (Isfahan). 2011 Oct;8(4):197-202. doi: 10.4103/1735-3327.86038.@@Matsumoto H, Hayashi S, Hatashita M, Ohnishi K, Shioura H, Ohtsubo T, Kitai R, Ohnishi T, Kano E: Induction of radioresistance by a nitric oxide-mediated bystander effect. Radiat Res. 2001 Mar;155(3):387-96. doi: 10.1667/0033-7587(2001)155[0387:iorban]2.0.co;2.@@Deng T, Xu K, Zhang L, Zheng X: Dynamic determination of Ox-LDL-induced oxidative/nitrosative stress in single macrophage by using fluorescent probes. Cell Biol Int. 2008 Nov;32(11):1425-32. doi: 10.1016/j.cellbi.2008.08.013. Epub 2008 Aug 20.@@MacAllister RJ, Whitley GS, Vallance P: Effects of guanidino and uremic compounds on nitric oxide pathways. Kidney Int. 1994 Mar;45(3):737-42. doi: 10.1038/ki.1994.98.@@Mahattanadul S, Reanmongkol W, Yano S, Panichayupakaranant P, Phdoongsombut N, Tungsinmunkong K: Preventive and curative effects of curcumin on the development of gastric inflammatory diseases in rats. J Nat Med. 2006 Jul;60(3):191-197. doi: 10.1007/s11418-006-0035-5. Epub 2006 Apr 28.@@Farhad AR, Razavi SM, Rozati AR, Shekarchizade N, Manshaei M: Selective nitric oxide synthase inhibitor promotes bone healing. Dent Res J (Isfahan). 2017 Sep-Oct;14(5):306-313. doi: 10.4103/1735-3327.215965.@@Trainor C, Butterworth KT, McGarry CK, McMahon SJ, O'Sullivan JM, Hounsell AR, Prise KM: DNA damage responses following exposure to modulated radiation fields. PLoS One. 2012;7(8):e43326. doi: 10.1371/journal.pone.0043326. Epub 2012 Aug 17.
GroupsInvestigational
Direct ClassificationGuanidines
SMILESNNC(N)=N
Pathways
PharmGKB
ChEMBLCHEMBL225304