| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30085618 | HIV | ENSG00000007171.19 | protein_coding | NOS2 | No | No | 4843 | P35228 |
| TVIS44042313 | HTLV-1 | ENSG00000007171.19 | protein_coding | NOS2 | No | No | 4843 | P35228 |
| TVIS44042312 | HTLV-1 | ENSG00000007171.19 | protein_coding | NOS2 | No | No | 4843 | P35228 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | NOS2 |
|---|---|
| DrugBank ID | DB01234 |
| Drug Name | Dexamethasone |
| Target ID | BE0000005 |
| UniProt ID | P35228 |
| Regulation Type | negative modulator |
| PubMed IDs | 17379310; 17494951; 17503181; 11752352 |
| Citations | Soderberg M, Raffalli-Mathieu F, Lang MA: Regulation of the murine inducible nitric oxide synthase gene by dexamethasone involves a heterogeneous nuclear ribonucleoprotein I (hnRNPI) dependent pathway. Mol Immunol. 2007 May;44(12):3204-10. Epub 2007 Mar 26.@@Huang H, Lavoie-Lamoureux A, Moran K, Lavoie JP: IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1147-54.@@Nandi J, Saud B, Zinkievich JM, Palma DT, Levine RA: 5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats. Dig Dis Sci. 2008 Jan;53(1):123-32. Epub 2007 May 15.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational; Vet_approved |
| Direct Classification | 21-hydroxysteroids |
| SMILES | [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C |
| Pathways | |
| PharmGKB | PA449247 |
| ChEMBL | CHEMBL384467 |
