| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30017029 | HIV | ENSG00000065989.16 | protein_coding | PDE4A | No | No | 5141 | P27815 |
| TVIS30047835 | HIV | ENSG00000065989.16 | protein_coding | PDE4A | No | No | 5141 | P27815 |
| TVIS30047836 | HIV | ENSG00000065989.16 | protein_coding | PDE4A | No | No | 5141 | P27815 |
| TVIS30047837 | HIV | ENSG00000065989.16 | protein_coding | PDE4A | No | No | 5141 | P27815 |
| TVIS30047838 | HIV | ENSG00000065989.16 | protein_coding | PDE4A | No | No | 5141 | P27815 |
| TVIS30047839 | HIV | ENSG00000065989.16 | protein_coding | PDE4A | No | No | 5141 | P27815 |
| TVIS20020749 | HPV | ENSG00000065989.16 | protein_coding | PDE4A | No | No | 5141 | P27815 |
| TVIS20020750 | HPV | ENSG00000065989.16 | protein_coding | PDE4A | No | No | 5141 | P27815 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PDE4A |
|---|---|
| DrugBank ID | DB00824 |
| Drug Name | Enprofylline |
| Target ID | BE0001133 |
| UniProt ID | P27815 |
| Regulation Type | inhibitor |
| PubMed IDs | 17670210; 1885257; 2262902; 3002801; 3446047; 11752352 |
| Citations | Featherstone RL, Chambers DJ: Long-term hypothermic lung preservation: does adenosine A1 receptor antagonism have a role in ischemic preconditioning protection? Interact Cardiovasc Thorac Surg. 2004 Mar;3(1):182-7.@@Dulloo AG, Seydoux J, Girardier L: Peripheral mechanisms of thermogenesis induced by ephedrine and caffeine in brown adipose tissue. Int J Obes. 1991 May;15(5):317-26.@@Dar MS: Central adenosinergic system involvement in ethanol-induced motor incoordination in mice. J Pharmacol Exp Ther. 1990 Dec;255(3):1202-9.@@Ukena D, Schirren CG, Schwabe U: Effects of enprofylline on A1 and A2 adenosine receptors. Eur J Pharmacol. 1985 Oct 29;117(1):25-33.@@Berg G, Andersson RG, Ryden G: Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study. Arch Int Pharmacodyn Ther. 1987 Dec;290(2):288-92.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Experimental |
| Direct Classification | Xanthines |
| SMILES | CCCN1C2=C(NC=N2)C(=O)NC1=O |
| Pathways | |
| PharmGKB | PA164749350 |
| ChEMBL | CHEMBL279898 |
