| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20064211 | HPV | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
| TVIS20064150 | HPV | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
| TVIS44027967 | HTLV-1 | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
| TVIS44049811 | HTLV-1 | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
| TVIS44035846 | HTLV-1 | ENSG00000147246.10 | protein_coding | HTR2C | No | No | 3358 | P28335 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HTR2C |
|---|---|
| DrugBank ID | DB01191 |
| Drug Name | Dexfenfluramine |
| Target ID | BE0000533 |
| UniProt ID | P28335 |
| Regulation Type | agonist |
| PubMed IDs | 10353435; 11198050; 11489456; 11888565; 12678838 |
| Citations | Vickers SP, Clifton PG, Dourish CT, Tecott LH: Reduced satiating effect of d-fenfluramine in serotonin 5-HT(2C) receptor mutant mice. Psychopharmacology (Berl). 1999 Apr;143(3):309-14.@@Wilson AW, Costall B, Neill JC: Manipulation of operant responding for an ethanol-paired conditioned stimulus in the rat by pharmacological alteration of the serotonergic system. J Psychopharmacol. 2000;14(4):340-6.@@Vickers SP, Dourish CT, Kennett GA: Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors. Neuropharmacology. 2001 Aug;41(2):200-9.@@Tomkins DM, Joharchi N, Tampakeras M, Martin JR, Wichmann J, Higgins GA: An investigation of the role of 5-HT(2C) receptors in modifying ethanol self-administration behaviour. Pharmacol Biochem Behav. 2002 Apr;71(4):735-44.@@Bickerdike MJ: 5-HT2C receptor agonists as potential drugs for the treatment of obesity. Curr Top Med Chem. 2003;3(8):885-97. |
| Groups | Approved; Illicit; Investigational; Withdrawn |
| Direct Classification | Amphetamines and derivatives |
| SMILES | CCN[C@@H](C)CC1=CC=CC(=C1)C(F)(F)F |
| Pathways | |
| PharmGKB | PA164747936 |
| ChEMBL | CHEMBL248702 |
