| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20024401 | HPV | ENSG00000131759.18 | protein_coding | RARA | No | No | 5914 | A8MUP8 P10276 Q6I9R7 |
| TVIS20021335 | HPV | ENSG00000131759.18 | protein_coding | RARA | No | No | 5914 | A8MUP8 P10276 Q6I9R7 |
| TVIS44049649 | HTLV-1 | ENSG00000131759.18 | protein_coding | RARA | No | No | 5914 | A8MUP8 P10276 Q6I9R7 |
| TVIS44049650 | HTLV-1 | ENSG00000131759.18 | protein_coding | RARA | No | No | 5914 | A8MUP8 P10276 Q6I9R7 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | RARA |
|---|---|
| DrugBank ID | DB00799 |
| Drug Name | Tazarotene |
| Target ID | BE0000663 |
| UniProt ID | P10276 |
| Regulation Type | agonist |
| PubMed IDs | 16144296; 9035701; 15383624; 14675762; 11519864; 10828316 |
| Citations | Baumann L, Vujevich J, Halem M, Martin LK, Kerdel F, Lazarus M, Pacheco H, Black L, Bryde J: Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging. Cutis. 2005 Jul;76(1):69-73.@@Chandraratna RA: Tazarotene--first of a new generation of receptor-selective retinoids. Br J Dermatol. 1996 Oct;135 Suppl 49:18-25.@@Yen A, Fenning R, Chandraratna R, Walker P, Varvayanis S: A retinoic acid receptor beta/gamma-selective prodrug (tazarotene) plus a retinoid X receptor ligand induces extracellular signal-regulated kinase activation, retinoblastoma hypophosphorylation, G0 arrest, and cell differentiation. Mol Pharmacol. 2004 Dec;66(6):1727-37. Epub 2004 Sep 21.@@Meder W, Wendland M, Busmann A, Kutzleb C, Spodsberg N, John H, Richter R, Schleuder D, Meyer M, Forssmann WG: Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23. FEBS Lett. 2003 Dec 18;555(3):495-9.@@Wang Q, Lee D, Sysounthone V, Chandraratna RAS, Christakos S, Korah R, Wieder R: 1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects. Breast Cancer Res Treat. 2001 May;67(2):157-68.@@Nagpal S, Chandraratna RA: Recent developments in receptor-selective retinoids. Curr Pharm Des. 2000 Jun;6(9):919-31. |
| Groups | Approved; Investigational |
| Direct Classification | Retinoids |
| SMILES | CCOC(=O)C1=CN=C(C=C1)C#CC1=CC2=C(SCCC2(C)C)C=C1 |
| Pathways | |
| PharmGKB | PA164746821 |
| ChEMBL | CHEMBL1657 |
