| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20024401 | HPV | ENSG00000131759.18 | protein_coding | RARA | No | No | 5914 | A8MUP8 P10276 Q6I9R7 |
| TVIS20021335 | HPV | ENSG00000131759.18 | protein_coding | RARA | No | No | 5914 | A8MUP8 P10276 Q6I9R7 |
| TVIS44049649 | HTLV-1 | ENSG00000131759.18 | protein_coding | RARA | No | No | 5914 | A8MUP8 P10276 Q6I9R7 |
| TVIS44049650 | HTLV-1 | ENSG00000131759.18 | protein_coding | RARA | No | No | 5914 | A8MUP8 P10276 Q6I9R7 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | RARA |
|---|---|
| DrugBank ID | DB00982 |
| Drug Name | Isotretinoin |
| Target ID | BE0000663 |
| UniProt ID | P10276 |
| Regulation Type | other/unknown |
| PubMed IDs | 10955779; 16983322; 9691099; 7601910; 9204085 |
| Citations | Dahl AR, Grossi IM, Houchens DP, Scovell LJ, Placke ME, Imondi AR, Stoner GD, De Luca LM, Wang D, Mulshine JL: Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study. Clin Cancer Res. 2000 Aug;6(8):3015-24.@@Zouboulis CC: Isotretinoin revisited: pluripotent effects on human sebaceous gland cells. J Invest Dermatol. 2006 Oct;126(10):2154-6.@@Vu-Dac N, Gervois P, Torra IP, Fruchart JC, Kosykh V, Kooistra T, Princen HM, Dallongeville J, Staels B: Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids. J Clin Invest. 1998 Aug 1;102(3):625-32.@@Taylor LE, Bennett GD, Finnell RH: Altered gene expression in murine branchial arches following in utero exposure to retinoic acid. J Craniofac Genet Dev Biol. 1995 Jan-Mar;15(1):13-25.@@Shroot B, Michel S: Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103. |
| Groups | Approved |
| Direct Classification | Retinoids |
| SMILES | CC(C=CC1=C(C)CCCC1(C)C)=C/C=C/C(/C)=CC(O)=O |
| Pathways | |
| PharmGKB | PA450128 |
| ChEMBL | CHEMBL547 |
