| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30067938 | HIV | ENSG00000128602.11 | protein_coding | SMO | Yes | No | 6608 | Q99835 |
| TVIS20068475 | HPV | ENSG00000128602.11 | protein_coding | SMO | Yes | No | 6608 | Q99835 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SMO |
|---|---|
| DrugBank ID | DB11978 |
| Drug Name | Glasdegib |
| Target ID | BE0004659 |
| UniProt ID | Q99835 |
| Regulation Type | inhibitor |
| PubMed IDs | 24900436 |
| Citations | Munchhof MJ, Li Q, Shavnya A, Borzillo GV, Boyden TL, Jones CS, LaGreca SD, Martinez-Alsina L, Patel N, Pelletier K, Reiter LA, Robbins MD, Tkalcevic GT: Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened. ACS Med Chem Lett. 2011 Dec 21;3(2):106-11. doi: 10.1021/ml2002423. eCollection 2012 Feb 9. |
| Groups | Approved; Investigational |
| Direct Classification | N-phenylureas |
| SMILES | CN1CC[C@H](C[C@@H]1C1=NC2=CC=CC=C2N1)NC(=O)NC1=CC=C(C=C1)C#N |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2043437 |
