| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44021886 | HTLV-1 | ENSG00000121966.8 | protein_coding | CXCR4 | Yes | No | 7852 | A0A0U3FJG0 A0A0U3GXA9 P61073 |
| TVIS44032449 | HTLV-1 | ENSG00000121966.8 | protein_coding | CXCR4 | Yes | No | 7852 | A0A0U3FJG0 A0A0U3GXA9 P61073 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | CXCR4 |
|---|---|
| DrugBank ID | DB00181 |
| Drug Name | Baclofen |
| Target ID | BE0000919 |
| UniProt ID | P61073 |
| Regulation Type | allosteric modulator |
| PubMed IDs | 23843532; 30459646 |
| Citations | Guyon A, Kussrow A, Olmsted IR, Sandoz G, Bornhop DJ, Nahon JL: Baclofen and other GABAB receptor agents are allosteric modulators of the CXCL12 chemokine receptor CXCR4. J Neurosci. 2013 Jul 10;33(28):11643-54. doi: 10.1523/JNEUROSCI.6070-11.2013.@@de Beaurepaire R: A Review of the Potential Mechanisms of Action of Baclofen in Alcohol Use Disorder. Front Psychiatry. 2018 Oct 17;9:506. doi: 10.3389/fpsyt.2018.00506. eCollection 2018. |
| Groups | Approved |
| Direct Classification | Gamma amino acids and derivatives |
| SMILES | NCC(CC(O)=O)C1=CC=C(Cl)C=C1 |
| Pathways | |
| PharmGKB | PA448533 |
| ChEMBL | CHEMBL701 |
