| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44021886 | HTLV-1 | ENSG00000121966.8 | protein_coding | CXCR4 | Yes | No | 7852 | A0A0U3FJG0 A0A0U3GXA9 P61073 |
| TVIS44032449 | HTLV-1 | ENSG00000121966.8 | protein_coding | CXCR4 | Yes | No | 7852 | A0A0U3FJG0 A0A0U3GXA9 P61073 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CXCR4 |
|---|---|
| DrugBank ID | DB06809 |
| Drug Name | Plerixafor |
| Target ID | BE0000919 |
| UniProt ID | P61073 |
| Regulation Type | antagonist |
| PubMed IDs | 18847313; 23204107; 34321159 |
| Citations | Uy GL, Rettig MP, Cashen AF: Plerixafor, a CXCR4 antagonist for the mobilization of hematopoietic stem cells. Expert Opin Biol Ther. 2008 Nov;8(11):1797-804. doi: 10.1517/14712598.8.11.1797 .@@Jujo K, Ii M, Sekiguchi H, Klyachko E, Misener S, Tanaka T, Tongers J, Roncalli J, Renault MA, Thorne T, Ito A, Clarke T, Kamide C, Tsurumi Y, Hagiwara N, Qin G, Asahi M, Losordo DW: CXC-chemokine receptor 4 antagonist AMD3100 promotes cardiac functional recovery after ischemia/reperfusion injury via endothelial nitric oxide synthase-dependent mechanism. Circulation. 2013 Jan 1;127(1):63-73. doi: 10.1161/CIRCULATIONAHA.112.099242. Epub 2012 Nov 30.@@Pan C, Liu P, Ma D, Zhang S, Ni M, Fang Q, Wang J: Bone marrow mesenchymal stem cells in microenvironment transform into cancer-associated fibroblasts to promote the progression of B-cell acute lymphoblastic leukemia. Biomed Pharmacother. 2020 Oct;130:110610. doi: 10.1016/j.biopha.2020.110610. Epub 2020 Aug 12. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylmethylamines |
| SMILES | C(N1CCCNCCNCCCNCC1)C1=CC=C(CN2CCCNCCNCCCNCC2)C=C1 |
| Pathways | |
| PharmGKB | PA165958410 |
| ChEMBL | CHEMBL18442 |
