| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10037138 | HBV | ENSG00000185313.9 | protein_coding | SCN10A | No | No | 6336 | Q9Y5Y9 |
| TVIS20042252 | HPV | ENSG00000185313.9 | protein_coding | SCN10A | No | No | 6336 | Q9Y5Y9 |
| TVIS44012590 | HTLV-1 | ENSG00000185313.9 | protein_coding | SCN10A | No | No | 6336 | Q9Y5Y9 |
| TVIS44019094 | HTLV-1 | ENSG00000185313.9 | protein_coding | SCN10A | No | No | 6336 | Q9Y5Y9 |
| TVIS44025068 | HTLV-1 | ENSG00000185313.9 | protein_coding | SCN10A | No | No | 6336 | Q9Y5Y9 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SCN10A |
|---|---|
| DrugBank ID | DB01086 |
| Drug Name | Benzocaine |
| Target ID | BE0000177 |
| UniProt ID | Q9Y5Y9 |
| Regulation Type | inhibitor |
| PubMed IDs | 17139284; 17016423; 17967784; 19661462; 16174788 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Ahern CA, Eastwood AL, Dougherty DA, Horn R: Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels. Circ Res. 2008 Jan 4;102(1):86-94. Epub 2007 Oct 25.@@Hanck DA, Nikitina E, McNulty MM, Fozzard HA, Lipkind GM, Sheets MF: Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity. Circ Res. 2009 Aug 28;105(5):492-9. doi: 10.1161/CIRCRESAHA.109.198572. Epub 2009 Aug 6.@@Lipkind GM, Fozzard HA: Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels. Mol Pharmacol. 2005 Dec;68(6):1611-22. Epub 2005 Sep 20. |
| Groups | Approved; Investigational |
| Direct Classification | Benzoic acid esters |
| SMILES | CCOC(=O)C1=CC=C(N)C=C1 |
| Pathways | Benzocaine Action Pathway |
| PharmGKB | PA448576 |
| ChEMBL | CHEMBL278172 |
