| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20001023 | HPV | ENSG00000120903.13 | protein_coding | CHRNA2 | No | No | 1135 | Q15822 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CHRNA2 |
|---|---|
| DrugBank ID | DB00657 |
| Drug Name | Mecamylamine |
| Target ID | BE0000738 |
| UniProt ID | Q15822 |
| Regulation Type | antagonist |
| PubMed IDs | 17139284; 17016423; 11752352; 19778551; 12080428 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Struthers AM, Wilkinson JL, Dwoskin LP, Crooks PA, Bevins RA: Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine. Pharmacol Biochem Behav. 2009 Dec;94(2):319-28. doi: 10.1016/j.pbb.2009.09.012. Epub 2009 Sep 22.@@Shytle RD, Penny E, Silver AA, Goldman J, Sanberg PR: Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens. 2002 Jul;16(7):453-7. |
| Groups | Approved; Investigational |
| Direct Classification | Bicyclic monoterpenoids |
| SMILES | CNC1(C)C2CCC(C2)C1(C)C |
| Pathways | |
| PharmGKB | PA450334 |
| ChEMBL | CHEMBL267936 |
