Gene: NAT2

10
AAC2|NAT-2|PNAT
N-acetyltransferase 2
protein-coding
8p22
Ensembl:ENSG00000156006 MIM:612182 Vega:OTTHUMG00000130826 UniprotKB:P11245
NG_012246.1
PubMed
ND|AD
282   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.634e-1 (AD)  3.030e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CARD180.584
OR7A170.529
TPRG10.514
HOXD120.492
OR12D10.49
GPX60.484
PCTP0.469
C8orf480.459
OR5D140.457
C9orf430.449

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAJC5G-0.36
PDE4C-0.325
THEM5-0.323
PHLDA2-0.311
TTLL11-0.31
THEG-0.305
CALHM1-0.299
MCHR1-0.298
C2CD4D-0.298
OPRD1-0.297

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00250DapsoneSmall Molecule80-08-0Approved|InvestigationalEnzyme
DB00316AcetaminophenSmall Molecule103-90-2ApprovedEnzyme
DB00951IsoniazidSmall Molecule54-85-3Approved|InvestigationalEnzyme
DB01015SulfamethoxazoleSmall Molecule723-46-6ApprovedEnzyme
DB01068ClonazepamSmall Molecule1622-61-3Approved|IllicitEnzyme
DB04953EzogabineSmall Molecule150812-12-7Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of NAT2 mRNA"21354444
C0152621,6-hexamethylene diisocyanate"NAT2 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate"11927838
C0211831,7-dimethylxanthine"NAT2 protein results in increased metabolism of 1,7-dimethylxanthine"19215233
C0211831,7-dimethylxanthine"[NAT2 protein results in increased metabolism of 1,7-dimethylxanthine] which results in increased chemical synthesis of 5-acetylamino-6-formylamino-3-methyluracil"19215233
C0010422',3-dimethyl-4-aminobiphenyl"NAT2 gene affects the susceptibility to 2',3-dimethyl-4-aminobiphenyl"8564966|8631131
C0010422',3-dimethyl-4-aminobiphenyl"NAT2 gene polymorphism affects the acetylation of 2',3-dimethyl-4-aminobiphenyl"12618593
C0010422',3-dimethyl-4-aminobiphenyl"NAT2 protein results in increased acetylation of 2',3-dimethyl-4-aminobiphenyl"12618593
C0010422',3-dimethyl-4-aminobiphenyl"NAT2 gene polymorphism affects the susceptibility to 2',3-dimethyl-4-aminobiphenyl"9356307
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of NAT2 mRNA"22138251
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"NAT2 protein polymorphism results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15110095
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"NAT2 protein results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"15110095
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"NAT2 protein results in increased acetylation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"19666988
C0369892-amino-3,4-dimethylimidazo(4,5-f)quinoline"[CYP3A7 co-treated with NAT2] results in increased susceptibility to 2-amino-3,4-dimethylimidazo(4,5-f)quinoline"7625840
C0369892-amino-3,4-dimethylimidazo(4,5-f)quinoline"NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3,4-dimethylimidazo(4,5-f)quinoline"28160022
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"[CYP3A7 co-treated with NAT2] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"7625840
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"28160022
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"[xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NAT2 mRNA"22138251
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"[Phenobarbital co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of NAT2 mRNA"23681119
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"NAT2 protein results in increased acetylation of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"19666988
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"NAT2 protein results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"19666988
C5464602-amino-3-methyl-3H-imidazo(4,5-f)quinoline"2-amino-3-methyl-3H-imidazo(4,5-f)quinoline results in decreased expression of NAT2 mRNA"23810796
C0178212-amino-3-methyl-9H-pyrido(2,3-b)indole"NAT2 protein results in increased activity of 2-amino-3-methyl-9H-pyrido(2,3-b)indole"14729582
C0178212-amino-3-methyl-9H-pyrido(2,3-b)indole"NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methyl-9H-pyrido(2,3-b)indole"28160022
C0292162-amino-3-methylimidazo(4,5-f)quinoline"[CYP3A7 co-treated with NAT2] results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline"7625840
C0292162-amino-3-methylimidazo(4,5-f)quinoline"NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline"28160022
C0292162-amino-3-methylimidazo(4,5-f)quinoline"NAT2 protein results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline"9150757
C0292162-amino-3-methylimidazo(4,5-f)quinoline"[NAT2 protein results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline] which results in increased mutagenesis of APRT gene"9150757
C4325232-amino-3-methylimidazo(4,5-f)quinoxaline"NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoxaline"28160022
C0237852-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole"NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole"28160022
C0178222-amino-9H-pyrido(2,3-b)indole"[CYP1A2 protein co-treated with NAT2 gene polymorphism] promotes the reaction [2-amino-9H-pyrido(2,3-b)indole binds to and results in increased mutagenesis of HPRT1 gene]"19243127
C0178222-amino-9H-pyrido(2,3-b)indole"NAT2 gene polymorphism affects the susceptibility to 2-amino-9H-pyrido(2,3-b)indole"19243127
C0178222-amino-9H-pyrido(2,3-b)indole"NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-9H-pyrido(2,3-b)indole"28160022
C0121772-aminofluoreneNAT2 protein polymorphism results in increased acetylation of 2-aminofluorene14722254
C0121772-aminofluoreneNAT2 protein results in increased acetylation of 2-aminofluorene12222688|1472225
C0121772-aminofluoreneNAT2 gene polymorphism affects the acetylation of 2-aminofluorene12618593
C0121772-aminofluoreneNAT2 protein results in increased acetylation of 2-aminofluorene12618593|1562748
C0121772-aminofluorene[Cadmium Chloride results in decreased activity of NAT2 protein] which affects the acetylation of 2-aminofluorene20810355
C0121772-aminofluoreneNAT2 protein results in increased metabolism of 2-aminofluorene16815960
C0121772-aminofluorene4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-aminofluorene]18842621
C0121772-aminofluoreneNAT2 protein results in increased acetylation of 2-aminofluorene18842621
C0038982-anisidineNAT2 protein results in increased activity of 2-anisidine15450435
C0757482-(bromoacetylamino)fluorene2-(bromoacetylamino)fluorene binds to NAT2 protein15106881
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"12222688
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"12618593
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"28536864
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]"18842621
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"18842621
C0320122-hydroxyamino-3-methylimidazolo(4,5-f)quinoline"NAT2 protein results in increased acetylation of and results in increased activity of 2-hydroxyamino-3-methylimidazolo(4,5-f)quinoline"12067565
C0124582-nitrosofluorene2-nitrosofluorene results in decreased activity of NAT2 protein19842618
C0454213,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine"NAT2 protein results in increased metabolism of and results in increased susceptibility to 3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine"28160022
C0144643,4-dichloroaniline"NAT2 protein results in increased acetylation of 3,4-dichloroaniline"15627487
C0144643,4-dichloroaniline"NAT2 protein results in increased acetylation of 3,4-dichloroaniline"15627487
C0689233,6-dinitrobenzopyrene"NAT2 protein results in increased metabolism of 3,6-dinitrobenzopyrene"19393727
C0191333-amino-1-methyl-5H-pyrido(4,3-b)indole"NAT2 protein results in increased metabolism of and results in increased susceptibility to 3-amino-1-methyl-5H-pyrido(4,3-b)indole"28160022
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of NAT2 mRNA18544908
C1172203-nitrobenzanthrone[NAT2 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene17483118
C1172203-nitrobenzanthrone[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]20545351
C1172203-nitrobenzanthrone[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]20545351
C1172203-nitrobenzanthroneNAT2 protein results in increased activity of 3-nitrobenzanthrone15805261
C1172203-nitrobenzanthroneNAT2 protein results in increased susceptibility to 3-nitrobenzanthrone17483118
C0095054,4'-diaminodiphenylmethane"NAT2 gene polymorphism affects the acetylation of 4,4'-diaminodiphenylmethane"16192314
C0095054,4'-diaminodiphenylmethane"NAT2 gene polymorphism results in increased susceptibility to 4,4'-diaminodiphenylmethane"16192314
C0095054,4'-diaminodiphenylmethane"NAT2 protein results in increased acetylation of 4,4'-diaminodiphenylmethane"16192314
C0059694,4'-diphenylmethane diisocyanate"NAT2 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate"11927838
C0138134-anisidineNAT2 protein results in increased acetylation of 4-anisidine15627487
C0067574-biphenylamineNAT2 gene polymorphism affects the susceptibility to 4-biphenylamine29180287
C0067574-biphenylamineNAT2 protein results in increased acetylation of 4-biphenylamine12222688
C0067574-biphenylamineNAT2 protein results in increased activity of 4-biphenylamine15450435
C0067574-biphenylamineNAT2 protein results in increased acetylation of 4-biphenylamine16482518
C0067574-biphenylamineNAT2 protein results in increased metabolism of 4-biphenylamine16815960|1685772
C0067574-biphenylamineNAT2 protein results in increased acetylation of 4-biphenylamine28536864
C0067574-biphenylamine4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-aminofluorene]18842621
C0067574-biphenylamine"4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]"18842621
C0067574-biphenylamine4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid]18842621
C0067574-biphenylamine4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-biphenylamine]18842621
C0067574-biphenylamine4-biphenylamine results in decreased activity of NAT2 protein18842621
C0067574-biphenylamineNAT2 protein results in increased acetylation of 4-biphenylamine18842621
C0236214-bromoanilineNAT2 protein results in increased acetylation of 4-bromoaniline15627487
C0236214-bromoanilineNAT2 protein results in increased acetylation of 4-bromoaniline15627487
C0046584-chloroanilineNAT2 protein results in increased acetylation of 4-chloroaniline15627487
C0046584-chloroanilineNAT2 protein results in increased acetylation of 4-chloroaniline15627487
C0728254-hexyloxyanilineNAT2 protein results in increased acetylation of 4-hexyloxyaniline15627487
C0728254-hexyloxyanilineNAT2 protein results in increased acetylation of 4-hexyloxyaniline15627487
C0130674-iodoanilineNAT2 protein results in increased acetylation of 4-iodoaniline15627487
C0130674-iodoanilineNAT2 protein results in increased acetylation of 4-iodoaniline15627487
C0086424-nitrophenyl acetateNAT2 protein results in increased acetylation of 4-nitrophenyl acetate15209520
C0723284-nitrosobiphenyl4-nitrosobiphenyl results in decreased activity of NAT2 protein19842618
C0297284-phenylenediamineNAT2 gene polymorphism affects the susceptibility to 4-phenylenediamine16533241
C0366925-acetylamino-6-formylamino-3-methyluracil"[NAT2 protein results in increased metabolism of 1,7-dimethylxanthine] which results in increased chemical synthesis of 5-acetylamino-6-formylamino-3-methyluracil"19215233
C4210109-(4'-aminophenyl)-9H-pyrido(3,4-b)indole"NAT2 protein affects the metabolism of 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole"17067997
C4210109-(4'-aminophenyl)-9H-pyrido(3,4-b)indole"NAT2 protein results in increased metabolism of and results in increased susceptibility to 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole"28160022
D000082AcetaminophenAcetaminophen results in decreased expression of NAT2 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of NAT2 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of NAT2 mRNA18544908
D000105Acetyl Coenzyme A[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]20545351
D000105Acetyl Coenzyme A[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]20545351
C510884acetylisoniazid[NAT2 gene polymorphism results in decreased acetylation of Isoniazid] which results in decreased abundance of acetylisoniazid18544910
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NAT2 mRNA22100608
D016604Aflatoxin B1[CYP3A7 co-treated with NAT2] results in increased susceptibility to Aflatoxin B17625840
D000588AminesNAT2 protein affects the metabolism of and results in increased activity of Amines12505289
D000588AminesNAT2 protein results in decreased activity of Amines15613766
D000588AminesNAT2 protein results in increased acetylation of Amines15122594
D000588AminesNAT2 protein results in increased activity of Amines15700302
D0101294-Aminobenzoic AcidNAT2 gene polymorphism affects the acetylation of 4-Aminobenzoic Acid12618593
D0101294-Aminobenzoic AcidNAT2 protein results in increased acetylation of 4-Aminobenzoic Acid12618593|1562748
D0101294-Aminobenzoic AcidNAT2 protein results in increased acetylation of 4-Aminobenzoic Acid15627487
D0101294-Aminobenzoic Acid4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid]18842621
D0101294-Aminobenzoic AcidNAT2 protein results in increased acetylation of 4-Aminobenzoic Acid18842621
D0150812-NaphthylamineNAT2 protein results in increased activity of 2-Naphthylamine15450435
D0150812-NaphthylamineNAT2 gene polymorphism affects the acetylation of 2-Naphthylamine12618593
D0150812-NaphthylamineNAT2 protein results in increased acetylation of 2-Naphthylamine12618593
D019804MesalamineNAT2 protein results in increased acetylation of Mesalamine15627487
D019804MesalamineNAT2 protein results in increased acetylation of Mesalamine15627487
D010131Aminosalicylic AcidNAT2 protein results in increased acetylation of Aminosalicylic Acid15627487|1600394
D010131Aminosalicylic Acid[Peroxynitrous Acid results in decreased activity of NAT2 protein] which results in decreased acetylation of Aminosalicylic Acid19248797
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NAT2 mRNA16483693
C023650anilineNAT2 protein results in increased acetylation of aniline15627487
D000814Aniline CompoundsNAT2 protein results in increased acetylation of Aniline Compounds analog15627487
D001194AsbestosNAT2 protein polymorphism affects the susceptibility to Asbestos15993904
D001241AspirinNAT2 polymorphism affects the susceptibility to Aspirin20602614
D001554BenzeneNAT2 gene polymorphism affects the susceptibility to Benzene15226677
D001554BenzeneNAT2 gene polymorphism results in increased susceptibility to Benzene15226677
D001554BenzeneNAT2 protein affects the metabolism of Benzene15226677
C029876benzidineNAT2 gene polymorphism affects the susceptibility to benzidine16003747
C029876benzidineNAT2 protein results in increased acetylation of benzidine28536864
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NAT2 mRNA21715664
D004958EstradiolEstradiol results in decreased expression of NAT2 mRNA20106945
D004958EstradiolEstradiol results in decreased expression of NAT2 mRNA18709148
C006780bisphenol Abisphenol A binds to and results in decreased activity of NAT2 protein18280460
C006780bisphenol Abisphenol A results in increased expression of NAT2 mRNA25181051
C056005bromoacetanilidebromoacetanilide results in decreased activity of and results in increased alkylation of NAT2 protein15106881
D019256Cadmium ChlorideCadmium Chloride binds to and results in decreased activity of NAT2 protein20810355
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of NAT2 protein20810355
D019256Cadmium Chloride[Cadmium Chloride results in decreased activity of NAT2 protein] which affects the acetylation of 2-aminofluorene20810355
D002110CaffeineNAT2 gene polymorphism affects the metabolism of Caffeine24221535
D002110CaffeineNAT2 protein affects the metabolism of Caffeine14586384|1458638
D002110CaffeineNAT2 protein results in increased acetylation of Caffeine15558239
D002220CarbamazepineCarbamazepine results in increased expression of NAT2 mRNA17112801
D002338CarotenoidsNAT2 protein polymorphism affects the susceptibility to Carotenoids15095308
D002753ChlorzoxazoneNAT2 protein affects the metabolism of Chlorzoxazone14586387
D009249NADP[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]20545351
D016572CyclosporineCyclosporine results in decreased expression of NAT2 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of NAT2 mRNA19770486
D003622DapsoneNAT2 protein results in increased acetylation of Dapsone14528063
D003622DapsoneNAT2 protein results in increased metabolism of Dapsone15999287
C526360dechlorane plusdechlorane plus results in decreased expression of NAT2 mRNA23245762
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of NAT2 mRNA18709148
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of NAT2 mRNA11323195
D004054DiethylstilbestrolDiethylstilbestrol results in decreased activity of NAT2 protein18280460
C010920dihydrofolatedihydrofolate results in decreased activity of NAT2 protein16003948
D002117CalcitriolCalcitriol results in decreased expression of NAT2 mRNA27107558
D002117CalcitriolCalcitriol results in increased expression of NAT2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of NAT2 mRNA21592394
C066888dimethocaineNAT2 protein results in increased acetylation of dimethocaine24309420
C096278DNA-(2-amino-3-methylimidazo(4,5-f)quinoline) adduct"NAT2 protein affects the abundance of DNA-(2-amino-3-methylimidazo(4,5-f)quinoline) adduct"11470991
C007366erythritol anhydrideNAT2 gene polymorphism results in decreased susceptibility to erythritol anhydride17078101
D0150732-AcetylaminofluoreneNAT2 protein results in increased activity of 2-Acetylaminofluorene15450435
D005492Folic AcidFolic Acid results in decreased activity of NAT2 protein16003948
D005492Folic AcidFolic Acid results in decreased activity of NAT2 protein modified form16003948
D005492Folic AcidNAT2 protein results in increased acetylation of Folic Acid metabolite15627487
D019833GenisteinGenistein results in decreased activity of NAT2 protein18280460
C023847Glu-P-2NAT2 protein results in increased metabolism of and results in increased susceptibility to Glu-P-228160022
C412815GW 4064GW 4064 promotes the reaction [NR1H4 protein binds to NAT2 gene]20091679
D006202Hair DyesNAT2 protein polymorphism affects the susceptibility to Hair Dyes12663508
D006571Heterocyclic CompoundsNAT2 protein affects the metabolism of and results in increased activity of Heterocyclic Compounds12505289
D006830HydralazineNAT2 protein affects the metabolism of Hydralazine15627487
D006830HydralazineNAT2 protein results in increased acetylation of Hydralazine15627487
C029424hydrazine[NAT2 gene polymorphism results in decreased metabolism of Isoniazid] which results in increased abundance of hydrazine18544910
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased activity of NAT2 protein15644493
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased activity of NAT2 protein19248797
D006881HydroxyacetylaminofluoreneHydroxyacetylaminofluorene results in decreased activity of NAT2 protein19842618
D007460IodoacetamideIodoacetamide results in decreased activity of NAT2 protein22835378
D007460IodoacetamideIodoacetamide results in decreased activity of and results in increased alkylation of NAT2 protein15209520
D007538IsoniazidNAT2 gene polymorphism affects the susceptibility to Isoniazid11379777|1191503
D007538IsoniazidNAT2 gene polymorphism results in decreased acetylation of Isoniazid18544910
D007538Isoniazid[NAT2 gene polymorphism results in decreased acetylation of Isoniazid] which results in decreased abundance of acetylisoniazid18544910
D007538Isoniazid[NAT2 gene polymorphism results in decreased metabolism of Isoniazid] which results in increased abundance of hydrazine18544910
D007538IsoniazidNAT2 gene SNP affects the susceptibility to Isoniazid25794903
D007538IsoniazidNAT2 protein affects the metabolism of Isoniazid15627487
D007538IsoniazidNAT2 protein polymorphism affects the metabolism of Isoniazid15546075|1590862
D007538IsoniazidNAT2 protein polymorphism results in increased acetylation of Isoniazid17973219
D007538IsoniazidNAT2 protein results in increased acetylation of Isoniazid11379777|1556534
D007538IsoniazidNAT2 protein results in increased metabolism of Isoniazid16531626|1684746
D007538IsoniazidIsoniazid results in decreased expression of NAT2 mRNA28619387
D007538Isoniazidsilybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA]28619387
D007538Isoniazid[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA28619387
D007538IsoniazidNAT2 protein affects the metabolism of Isoniazid15855489
D007538IsoniazidNAT2 protein polymorphism affects the susceptibility to Isoniazid15855489
D007538IsoniazidNAT2 protein results in increased metabolism of Isoniazid17950035
D003915DextromethorphanNAT2 protein affects the metabolism of Dextromethorphan15199075
D008727MethotrexateMethotrexate results in decreased activity of NAT2 protein16003948
D008727MethotrexateMethotrexate results in decreased activity of NAT2 protein modified form16003948
D008753Methylenebis(chloroaniline)Methylenebis(chloroaniline) binds to NAT2 protein29180287
D008753Methylenebis(chloroaniline)NAT2 protein results in increased acetylation of Methylenebis(chloroaniline)29180287
D008753Methylenebis(chloroaniline)NAT2 protein results in increased acetylation of Methylenebis(chloroaniline) analog29180287
C568376MT19c compoundMT19c compound results in increased expression of NAT2 mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NAT2 mRNA"25554681
C016272N-bromoacetamideN-bromoacetamide results in decreased activity of and results in increased alkylation of NAT2 protein15209520
C001368N-hydroxy-2-aminofluoreneNAT2 protein results in increased acetylation of N-hydroxy-2-aminofluorene12618593
C001365N-hydroxy-4-acetylaminobiphenylN-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT2 protein15720122
C001365N-hydroxy-4-acetylaminobiphenylN-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT2 protein19842618
C014593N-hydroxy-4-aminobiphenylNAT2 protein results in increased acetylation of N-hydroxy-4-aminobiphenyl12618593
C014593N-hydroxy-4-aminobiphenylNAT2 protein results in increased metabolism of N-hydroxy-4-aminobiphenyl16857729
C007350nitrofenNAT2 protein results in increased activity of nitrofen14754874
C025589ochratoxin Aochratoxin A results in decreased expression of NAT2 mRNA26505656
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NAT2 mRNA27153767
C023036perfluorooctanoic acid[perfluorooctanoic acid co-treated with PPARA] results in increased expression of NAT2 mRNA20118188
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NAT2 mRNA20118188
D030421Peroxynitrous AcidPeroxynitrous Acid results in decreased activity of NAT2 protein15644493
D030421Peroxynitrous AcidPeroxynitrous Acid results in decreased activity of NAT2 protein19248797
D030421Peroxynitrous Acid[Peroxynitrous Acid results in decreased activity of NAT2 protein] which results in decreased acetylation of Aminosalicylic Acid19248797
D010634Phenobarbital"[Phenobarbital co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of NAT2 mRNA"23681119
C030299phenylhydrazineNAT2 protein results in increased acetylation of phenylhydrazine15627487
D010724Phosphoadenosine Phosphosulfate[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]20545351
D011084Polycyclic Aromatic HydrocarbonsNAT2 gene polymorphism affects the secretion of Polycyclic Aromatic Hydrocarbons21359562
D011084Polycyclic Aromatic HydrocarbonsNAT2 protein results in increased acetylation of Polycyclic Aromatic Hydrocarbons15122594
C095911polycyclic aromatic hydrocarbons-DNA adductNAT2 protein polymorphism results in increased abundance of polycyclic aromatic hydrocarbons-DNA adduct11967624
D011342ProcainamideNAT2 protein affects the acetylation of Procainamide15930747
D011342ProcainamideNAT2 protein results in increased acetylation of Procainamide16003948
C035988procymidoneprocymidone results in increased expression of NAT2 mRNA15686871
D011441PropylthiouracilPropylthiouracil results in decreased expression of NAT2 mRNA24780913
D011794QuercetinQuercetin results in increased activity of NAT2 protein19215233
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NAT2 mRNA19073995
C440975silybinsilybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA]28619387
C076731simendanNAT2 protein polymorphism results in increased acetylation of and results in increased activity of simendan15489122
C076731simendanNAT2 protein results in increased acetylation of and results in increased activity of simendan15489122
D012906SmokeNAT2 gene polymorphism affects the susceptibility to Smoke19692670
C016104sodium bichromatesodium bichromate results in increased expression of NAT2 mRNA12325037
D012969Sodium FluorideSodium Fluoride results in decreased expression of NAT2 mRNA27862939
D013411SulfadiazineNAT2 protein results in increased acetylation of Sulfadiazine15843491
D013418SulfamethazineNAT2 polymorphism affects the acetylation of Sulfamethazine28516247
D013418SulfamethazineNAT2 protein results in increased acetylation of Sulfamethazine12222688|1562748
D013418SulfamethazineNAT2 protein results in increased acetylation of Sulfamethazine28536864
D013418SulfamethazineNAT2 protein results in increased acetylation of Sulfamethazine11470991
D013420SulfamethoxazoleNAT2 protein results in increased metabolism of Sulfamethoxazole16847467
D013427SulfapyridineNAT2 gene polymorphism affects the acetylation of Sulfapyridine18167504
D013427SulfapyridineNAT2 protein results in increased acetylation of Sulfapyridine18167504
D012460SulfasalazineNAT2 gene polymorphism affects the metabolism of Sulfasalazine19560446
D012460SulfasalazineNAT2 protein affects the metabolism of Sulfasalazine15032315
D012460SulfasalazineNAT2 protein affects the susceptibility to Sulfasalazine15032315|1737764
D012460SulfasalazineNAT2 protein polymorphism affects the metabolism of Sulfasalazine15032315
D012460SulfasalazineNAT2 protein results in increased acetylation of Sulfasalazine12465141
D012460SulfasalazineNAT2 protein results in increased metabolism of Sulfasalazine19560446
D013449SulfonamidesNAT2 protein affects the metabolism of Sulfonamides15627487
D013629TamoxifenTamoxifen results in decreased activity of NAT2 protein18280460
D000069459Teas, Herbal"Teas, Herbal results in decreased activity of NAT2 protein"28011360
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of NAT2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of NAT2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NAT2 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NAT2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NAT2 mRNA18434241|1993321
D014051Toluene 2,4-Diisocyanate"NAT2 protein polymorphism results in increased susceptibility to Toluene 2,4-Diisocyanate"11927838
D014241TrichloroethyleneNAT2 gene polymorphism results in increased susceptibility to Trichloroethylene19834256
D014241TrichloroethyleneTrichloroethylene results in decreased expression of NAT2 mRNA19448997
C012589trichostatin Atrichostatin A results in increased expression of NAT2 mRNA24935251
C057693troglitazonetroglitazone results in increased expression of NAT2 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of NAT2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NAT2 mRNA24935251|2800136
D001335Vehicle EmissionsVehicle Emissions affects the methylation of NAT2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of NAT2 mRNA15686871
C029297vinylidene chloridevinylidene chloride results in decreased expression of NAT2 mRNA26682919
C104536xanthohumol"[xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NAT2 mRNA"22138251
D015215Zidovudinesilybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA]28619387
D015215Zidovudine[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA28619387
D015215ZidovudineZidovudine results in decreased expression of NAT2 mRNA28619387

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004060arylamine N-acetyltransferase activity-IBA21873635  
GO:0004060arylamine N-acetyltransferase activity-TAS-  
GO:0005515protein binding-IPI25640309  
GO ID GO Term Qualifier Evidence PubMed
GO:0006805xenobiotic metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00232Caffeine metabolism
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156582AcetylationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28397463Colorectal Cancer Carcinogenesis: a Multivariate Genetic Model in a Cohort of Romanian Population. (2017 Apr 1)Procopciuc LMClin Lab
10591543N-acetyltransferase-2 polymorphism, smoking and type 1 diabetic nephropathy. (1999 Oct)Korpinen EPharmacogenetics
9288889Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl-DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation, and peroxidation. (1997 Aug 1)Culp SJMutat Res
27068825N-acetyltransferase 2 polymorphism and breast cancer risk with smoking: a case control study in Japanese women. (2017 Mar)Hara ABreast Cancer
11207033Variation in enzymes of arylamine procarcinogen biotransformation among bladder cancer patients and control subjects. (2001 Feb)Vaziri SAPharmacogenetics
12505352The relationship between polymorphisms of xenobiotic metabolizing enzymes and susceptibility to cancer. (2002 Dec 27)Vineis PToxicology
11202642[Role of xenobiotic biotransformation enzymes in susceptibility to bronchial asthma and in formation of its clinical phenotypic features]. (2000)Liakhovich VVVestn Ross Akad Med Nauk
15342459Impact of misclassification in genotype-exposure interaction studies: example of N-acetyltransferase 2 (NAT2), smoking, and bladder cancer. (2004 Sep)Deitz ACCancer Epidemiol Biomarkers Prev
8200080Modulation of urinary mutagenicity by genetically determined carcinogen metabolism in smokers. (1994 May)Hirvonen ACarcinogenesis
12376500XPD codon 751 polymorphism, metabolism genes, smoking, and bladder cancer risk. (2002 Oct)Stern MCCancer Epidemiol Biomarkers Prev
17569138NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations. (2007 May 21)Al-Moundhri MSWorld J Gastroenterol
11911601Assessment of frequencies of lifestyle factors and polymorphisms of drug-metabolizing enzymes (NAT2, CYP2E1) in human hepatocellular carcinoma (HCC) patients in a department of surgical medicine--a pilot investigation. (2002 Mar)Farker KInt J Clin Pharmacol Ther
16504378Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk. (2007 Jan 8)Kellen ECancer Lett
20847076Genetic susceptibility to asbestos-related fibrotic pleuropulmonary changes. (2011 Sep)Kukkonen MKEur Respir J
12708724Association of NAT2 and smoking in relation to breast cancer incidence in a population-based case-control study (United States). (2003 Feb)Egan KMCancer Causes Control
23899393Influence of GSTM1 and NAT2 genotypes on the relationship between personal exposure to PAH and biomarkers of internal dose. (1998)Costa DJBiomarkers
21927616Genetic susceptibility to bladder cancer risk and outcome. (2011 May)Gu JPer Med
17530260Epidemiology of urinary bladder cancer: from tumor development to patient's death. (2007 Jun)Murta-Nascimento CWorld J Urol
7543377Relationship between hprt mutant frequency, aromatic DNA adducts and genotypes for GSTM1 and NAT2 in bus maintenance workers. (1995 Aug)Hou SMCarcinogenesis
10507782Genetic polymorphisms of N-acetyltransferase 1 and 2 and risk of cigarette smoking-related bladder cancer. (1999 Oct)Hsieh FIBr J Cancer
24467372GSTM1-null genotype as a risk factor for sporadic colorectal cancer in a Romanian population. Association with the NAT2-rapid-acetylator phenotype and exposure to environmental factors. (2014 Feb)Procopciuc LMCancer Invest
23226745Association of NAT2 polymorphisms with risk of colorectal adenomas: Evidence from 3,197 cases and 4,681 controls. (2012 Nov)Zhuo WExp Ther Med
15829318Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway. (2005 May)Skuladottir HLung Cancer
19588544Combined effect of NAT2, MTR and MTHFR genotypes and tobacco on bladder cancer susceptibility in Tunisian population. (2009)Ouerhani SCancer Detect Prev
24928356Synergism between the N-acetyltransferase 2 gene and oxidant exposure increases the risk of idiopathic male infertility. (2014 Sep)Yarosh SLReprod Biomed Online
15496536CYP1A1, cigarette smoking, and colon and rectal cancer. (2004 Nov 1)Slattery MLAm J Epidemiol
9014203Polymorphic enzymes of xenobiotic metabolism as modulators of acquired P53 mutations in bladder cancer. (1996 Dec)Brockmoller JPharmacogenetics
16251120N-acetyltransferase 2 phenotype may be associated with susceptibility to age-related cataract. (2005 Oct)Tamer LCurr Eye Res
14504191Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer. (2003 Sep)Zhu JCancer Epidemiol Biomarkers Prev
22105431Comparison of N-acetyltransferase-2 enzyme genotype-phenotype and xanthine oxidase enzyme activity between Swedes and Koreans. (2012 Oct)Djordjevic NJ Clin Pharmacol
10917561N-acetyltransferase 2 and bladder cancer: an overview and consideration of the evidence for gene-environment interaction. (2000 Aug)Green JBr J Cancer
24793319The role of cigarette smoking and liver enzymes polymorphisms in anti-tuberculosis drug-induced hepatotoxicity in Brazilian patients. (2014 May)Zaverucha-do-Valle CTuberculosis (Edinb)
28696897Polymorphisms of xenobiotic metabolizing enzymes in bladder cancer patients of the Semmelweis University Budapest, Hungary. (2017)Ebbinghaus DJ Toxicol Environ Health A
15808403'Comparison of extremes' approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibility. (2005 Apr 28)Belogubova EVCancer Lett
12552951Correlation of the genotypes for N-acetyltransferases 1 and 2 with double bladder and prostate cancers in a case-comparison study. (2002 Nov-Dec)Wang CYAnticancer Res
12872524Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes. (2003 Jun)Thier RInt J Hyg Environ Health
12402313Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population. (2002 Dec 1)Ozawa SInt J Cancer
19467981Do smoking and polymorphisms in xenobiotic metabolizing enzymes affect the histological stage and grade of bladder tumors? (2009 May)Ouerhani SBull Cancer
15743503SULT1A1 genotype, active and passive smoking, and breast cancer risk by age 50 years in a German case-control study. (2005)Lilla CBreast Cancer Res
20739907A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background. (2011 Apr)Garcia-Closas MPharmacogenet Genomics
14706514Urinary 1-hydroxypyrene and mutagenicity in bus drivers and mail carriers exposed to urban air pollution in Denmark. (2004 Jan 10)Hansen AMMutat Res
9725993Coke oven workers study: the effect of exposure and GSTM1 and NAT2 genotypes on DNA adduct levels in white blood cells and lymphocytes as determined by 32P-postlabelling. (1998 Aug 7)Binkova BMutat Res
18499698Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer. (2008 Jun)Suzuki HCarcinogenesis
24950597Pre-diagnostic smoking behaviour and poorer prognosis in a German breast cancer patient cohort - Differential effects by tumour subtype, NAT2 status, BMI and alcohol intake. (2014 Aug)Seibold PCancer Epidemiol
12074508Meat consumption, cigarette smoking, and genetic susceptibility in the etiology of colorectal cancer: results from a Dutch prospective study. (2002 May)Tiemersma EWCancer Causes Control
12018173[Polymorphic genes of xenobiotic-metabolizing enzymes associated with bronchial asthma in genetically predisposed children]. (2002 Apr)Vavilin VAGenetika
22293947Joint effect of polymorphism in the N-acetyltransferase 2 gene and smoking on hepatocellular carcinoma. (2012 Aug)Zhang JTumour Biol
15093278Cytogenetic biomarkers and genetic polymorphisms. (2004 Apr 1)Norppa HToxicol Lett
12727801Evaluation of 4-aminobiphenyl-DNA adducts in human breast cancer: the influence of tobacco smoke. (2003 Apr)Faraglia BCarcinogenesis
24668907Maternal smoking, xenobiotic metabolizing enzyme gene variants, and gastroschisis risk. (2014 Jun)Jenkins MMAm J Med Genet A
18187392Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysis. (2008 Jan)Ambrosone CBCancer Epidemiol Biomarkers Prev
9806162A pilot study testing the association between N-acetyltransferases 1 and 2 and risk of oral squamous cell carcinoma in Japanese people. (1998 Oct)Katoh TCarcinogenesis
10741511Aromatic DNA adducts in coke-oven workers, in relation to exposure, lifestyle and genetic polymorphism of metabolic enzymes. (2000 Mar)Zhang JInt Arch Occup Environ Health
16721725Tobacco smoking, NAT2 acetylation genotype and breast cancer risk. (2006 Oct 15)Lissowska JInt J Cancer
14618622Effect of SULT1A1 and NAT2 genetic polymorphism on the association between cigarette smoking and colorectal adenomas. (2004 Jan 1)Tiemersma EWInt J Cancer
19012698Cigarette smoking and glutathione S-transferase M1 polymorphism associated with risk for uterine cervical cancer. (2008 Dec)Nishino KJ Obstet Gynaecol Res
15095308Carotenoids/vitamin C and smoking-related bladder cancer. (2004 Jun 20)Castelao JEInt J Cancer
18006927Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer. (2007 Nov)Jiao LCancer Epidemiol Biomarkers Prev
9568791White blood cell DNA adducts, smoking, and NAT2 and GSTM1 genotypes in bladder cancer: a case-control study. (1998 Apr)Peluso MCancer Epidemiol Biomarkers Prev
22628494Heterocyclic amine intake, smoking, cytochrome P450 1A2 and N-acetylation phenotypes, and risk of colorectal adenoma in a multiethnic population. (2013 Mar)Voutsinas JGut
19589345Gene-smoking interaction on colorectal adenoma and cancer risk: review and meta-analysis. (2009 Nov 2)Raimondi SMutat Res
24449363Association of CYP1A1 and CYP2D6 gene polymorphisms with head and neck cancer in Tunisian patients. (2014)Khlifi RMol Biol Rep
27510252Pharmacokinetics of thrice-weekly rifampicin, isoniazid and pyrazinamide in adult tuberculosis patients in India. (2016 Sep)Hemanth Kumar AKInt J Tuberc Lung Dis
7757072Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer. (1995 Feb)Risch AHum Mol Genet
23885983The choice of controls in a case-control study on WBC-DNA adducts and metabolic polymorphisms. (2000)Sacerdote CBiomarkers
27495060rs1495741 as a tag single nucleotide polymorphism of N-acetyltransferase 2 acetylator phenotype associates bladder cancer risk and interacts with smoking: A systematic review and meta-analysis. (2016 Aug)Ma CMedicine (Baltimore)
29721061The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis. (2018)Du LJ Cancer
15987714Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer. (2006 Jan)Li DCarcinogenesis
10510890NAT2 gene polymorphism as a possible marker for susceptibility to bladder cancer in Japanese. (1999 Sep)Inatomi HInt J Urol
19118072Role of the N-acetyltransferase 2 detoxification system in thyroid cancer susceptibility. (2009 Jan 1)Guilhen ACClin Cancer Res
9799179Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1. (1998 Nov)Mendola PEpidemiology
20801937N-Acetyltransferase-2 (NAT2) gene polymorphisms and enzyme activity in Serbs: unprecedented high prevalence of rapid acetylators in a White population. (2011 Jul)Djordjevic NJ Clin Pharmacol
12622714N-acetyltransferase-2 gene polymorphism as a possible biomarker for prostate cancer in Japanese men. (2003 Mar)Hamasaki TInt J Urol
12097450Expression of N-acetyltransferases in periodontal granulation tissue. (2002 May)Meisel PJ Dent Res
9255556Interaction between dose and susceptibility to environmental cancer: a short review. (1997 Jun)Hietanen EEnviron Health Perspect
29681089Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida. (2018 May)Padula AMAm J Med Genet A
22000673Risk factor for clear cell renal cell carcinoma in Chinese population: a case-control study. (2012 Apr)Wang GCancer Epidemiol
15609332NAT2 slow acetylator genotype as an important modifier of breast cancer risk. (2005 Apr 20)Sillanpaa PInt J Cancer
23660777Association of NAT1 and NAT2 genes with nonsyndromic cleft lip and palate. (2013 Jul)Song TMol Med Rep
17160896Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants. (2007 Jan)Shi MAm J Hum Genet
9729241Cytogenetic monitoring in coke oven workers. (1998 Sep 1)Kalina IMutat Res
8895986Cytochrome P-450 and acetyltransferase expression as biomarkers of carcinogen-DNA adduct levels and human cancer susceptibility. (1996)Badawi AFProg Clin Biol Res
15688397N-Acetyltransferase-2, glutathione S-transferase M1 and T1 genetic polymorphisms, cigarette smoking and hepatocellular carcinoma: a case-control study. (2005 Jun 10)Gelatti UInt J Cancer
22881407Analysis of secondary phenotype involving the interactive effect of the secondary phenotype and genetic variants on the primary disease. (2012 Nov)Wang JAnn Hum Genet
14601045Genetic polymorphisms and modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in human lymphocytes. (2003 Dec 20)Magagnotti CInt J Cancer
11266080Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility. (2001 Mar)Wikman HPharmacogenetics
15746160Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. (2005 Jul)Broberg KCarcinogenesis
22200898Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE). (2012 Feb)Bonaventure ACancer Causes Control
9230278Relationship between acetylator status, smoking, and diet and colorectal cancer risk in the north-east of England. (1997 Jul)Welfare MRCarcinogenesis
21432881Bayesian inference of gene-environment interaction from incomplete data: what happens when information on environment is disjoint from data on gene and disease? (2011 Apr 15)Gustafson PStat Med
24221535Refinement of the prediction of N-acetyltransferase 2 (NAT2) phenotypes with respect to enzyme activity and urinary bladder cancer risk. (2013 Dec)Selinski SArch Toxicol
15890241NAT2 fast acetylator genotype is associated with an increased risk of lung cancer among never-smoking women in Taiwan. (2005 Jun 1)Chiou HLCancer Lett
23885830Implication of arylamine N-acetyltransferase (NAT2) polymorphism on levels of tumour markers CEA, AFP, CA 125, CA 19.9, and CA 15.3. (1999)Necat Yilmaz A Sukru Aynacioglu Binnur Erbagci Ingolf Cascorbi Ivar RootsBiomarkers
17512776Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and genetic polymorphisms in breast cancer patients. (2007 Jul 10)Kuo HWMutat Res
8597072Analysis of mutation at the hprt locus in human T lymphocytes. (1995 Dec)Lambert BToxicol Lett
17490987Retrospective analysis of haplotype-based case control studies under a flexible model for gene environment association. (2008 Jan)Chen YHBiostatistics
12654968Strong association between N-acetyltransferase 2 genotype and PD in Hong Kong Chinese. (2003 Mar 25)Chan DKNeurology
17418242Chromosomal aberrations in environmentally exposed population in relation to metabolic and DNA repair genes polymorphisms. (2007 Jul 1)Sram RJMutat Res
8579380Habitual and genetic factors that affect urinary background levels of biomarkers for organic solvent exposure. (1996 Jan)Kawamoto TArch Environ Contam Toxicol
16049806Cumulative genetic defects in carcinogen metabolism may increase breast cancer risk (The Netherlands). (2005 Aug)van der Hel OLCancer Causes Control
8412184Metabolic activation, DNA adducts, and H-ras mutations in human neoplastic and non-neoplastic laryngeal tissue. (1993)Stern SJJ Cell Biochem Suppl
22246524N-acetyltransferase-2 gene polymorphisms and prostate cancer susceptibility in Latin American patients. (2012 Dec)de Lima Junior MMMed Oncol
22403658Absence of association between N-acetyltransferase 2 acetylator status and colorectal cancer susceptibility: based on evidence from 40 studies. (2012)Zhang LqPLoS One
19368118MnSOD genotype and prostate cancer risk as a function of NAT genotype and smoking status. (2009 Jan-Feb)Iguchi TIn Vivo
22645715Xenobiotic metabolizing gene variants and renal cell cancer: a multicenter study. (2012)Heck JEFront Oncol
21359562Modulation of urinary polycyclic aromatic hydrocarbon metabolites by enzyme polymorphisms in workers of the German Human Bitumen Study. (2011 Jun)Rihs HPArch Toxicol
20937634Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk. (2010 Nov 1)Cleary SPAm J Epidemiol
12037246Organic solvent exposure, genes, and risk of neuropsychological impairment. (2002 Jun)Dick FQJM
11934439Association of DNA-protein crosslinks and breast cancer. (2002 Apr 25)Wu FYMutat Res
14504199Associations between smoking, passive smoking, GSTM-1, NAT2, and rectal cancer. (2003 Sep)Slattery MLCancer Epidemiol Biomarkers Prev
9107426Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking. (1997 Apr)Okkels HCancer Epidemiol Biomarkers Prev
16003747NAT2 slow acetylation and bladder cancer in workers exposed to benzidine. (2006 Jan 1)Carreon TInt J Cancer
8752164Homozygous rapid arylamine N-acetyltransferase (NAT2) genotype as a susceptibility factor for lung cancer. (1996 Sep 1)Cascorbi ICancer Res
11220663Hepatocellular carcinoma: susceptibility markers. (2001)Blum HEIARC Sci Publ
21390146N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer. (2011 Feb 14)da Silva TDWorld J Gastroenterol
10935938Impairment of colour vision in workers exposed to organic solvents. (2000 Sep)Semple SOccup Environ Med
15355699[Effect of genetic polymorphisms of microsomal epoxide hydrolase on urinary 1-hydroxypyrene levels in coke oven workers]. (2004 Aug)Leng SGZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
11751443Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk. (2001 Dec)Le Marchand LCancer Epidemiol Biomarkers Prev
10208649Association of arylamine N-acetyltransferases NAT1 and NAT2 genotypes to laryngeal cancer risk. (1999 Feb)Henning SPharmacogenetics
11005681Polymorphism of the N-acetyltransferase (NAT2), smoking and the potential risk of periodontal disease. (2000 Aug)Meisel PArch Toxicol
21056942Environmental tobacco smoke in relation to bladder cancer risk--the Shanghai bladder cancer study [corrected]. (2010 Dec)Tao LCancer Epidemiol Biomarkers Prev
12397635Orofacial clefts and spina bifida: N-acetyltransferase phenotype, maternal smoking, and medication use. (2002 Nov)van Rooij IATeratology
19334527[Association of NAT2 polymorphism with risks to develop psoriasis and various dermatological diseases in Moscow population]. (2009 Jan-Feb)Kozhekbaeva ZhMMol Biol (Mosk)
9796632Glutathione S-transferase mu1 and N-acetyltransferase 2 genetic polymorphisms and exposure to tobacco smoke in nonsmoking and smoking lung cancer patients and population controls. (1998 Oct)Nyberg FCancer Epidemiol Biomarkers Prev
11815396Genetic polymorphisms in N-acetyltransferase-2 and microsomal epoxide hydrolase, cumulative cigarette smoking, and lung cancer. (2002 Jan)Zhou WCancer Epidemiol Biomarkers Prev
14564055Association of arylamine N-acetyltransferase (NAT1 and NAT2) genotypes with urinary bladder cancer risk. (2001)Jaskula-Sztul RJ Appl Genet
22108250Influence of CYP2C9, GSTM1, GSTT1 and NAT2 genetic polymorphisms on DNA damage in workers occupationally exposed to organophosphate pesticides. (2012 Jan 24)Singh SMutat Res
1306111Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. (1992 Jun)Butler MAPharmacogenetics
10933269Breast cancer and active and passive smoking: the role of the N-acetyltransferase 2 genotype. (2000 Aug 1)Morabia AAm J Epidemiol
17996038Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population. (2007 Nov 8)Boccia SBMC Cancer
18019020Analysis of associations of NAT2 gene polymorphisms with the risk of lung cancer. (2007 Jan)Nikishina MVBull Exp Biol Med
21292342NAT2 polymorphism and lung cancer risk: a meta-analysis. (2011 Aug)Cui DLung Cancer
10868698N-acetyltransferase 2 phenotype but not NAT1*10 genotype affects aminobiphenyl-hemoglobin adduct levels. (2000 Jun)Probst-Hensch NMCancer Epidemiol Biomarkers Prev
11214777Correlation between acetylation phenotype and genotype in Chinese women. (2000 Dec)Zhao BEur J Clin Pharmacol
23404349Childhood acute leukemia, maternal beverage intake during pregnancy, and metabolic polymorphisms. (2013 Apr)Bonaventure ACancer Causes Control
12663508Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2. (2003 Mar)Gago-Dominguez MCarcinogenesis
21432481N-Acetyltransferase polymorphism and human cancer risk. (2000 Jan)Yang XEnviron Health Prev Med
16827944N-acetyltransferase 2 (NAT2) gene polymorphisms in colon and lung cancer patients. (2006 Jul 9)Borlak JBMC Med Genet
14648207Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer. (2004 Feb)Tsukino HJ Cancer Res Clin Oncol
16614098Is the association between cigarette smoking and breast cancer modified by genotype? A review of epidemiologic studies and meta-analysis. (2006 Apr)Terry PDCancer Epidemiol Biomarkers Prev
28743105Statistical Interactions from a Growth Curve Perspective. (2016)Devlin SMHum Hered
21709725No association between variant N-acetyltransferase genes, cigarette smoking and Prostate Cancer susceptibility among men of African descent. (2011 Feb 3)Kidd LCBiomark Cancer
10464641Evaluation of genotype data in clinical risk assessment: methods and application to BRCA1, BRCA2, and N-acetyl transferase-2 genotypes in breast cancer. (1997-1998)Rebbeck TRGenet Test
12814209Rapid N-acetyltransferase 2 imputed phenotype and smoking may increase risk of colorectal cancer in women (Netherlands). (2003 Apr)van der Hel OLCancer Causes Control
15061915[A study on the inherited susceptibility of chromosomal damage in peripheral blood lymphocytes among coke oven workers]. (2004 Mar)Leng SGZhonghua Yu Fang Yi Xue Za Zhi
12082022Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity. (2002 Jun)Tuimala JCarcinogenesis
16926176Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps. (2007 Feb)Goode ELCarcinogenesis
25005845N-Acetyltransferase 2 (NAT2) gene polymorphism and exposure to smoking in lung cancer of Chinese males. (2014 Aug)Tian FMed Oncol
9950242Colorectal adenomatous and hyperplastic polyps: smoking and N-acetyltransferase 2 polymorphisms. (1999 Jan)Potter JDCancer Epidemiol Biomarkers Prev
18798002Coffee consumption, genetic susceptibility and bladder cancer risk. (2009 Feb)Villanueva CMCancer Causes Control
21738036Familial bladder cancer and the related genes. (2011 Sep)Hemminki KCurr Opin Urol
20870921Bladder Cancer Working Group report. (2010 Sep)Kakehi YJpn J Clin Oncol
11285205Cytochrome P4501A2 (CYP1A2) activity and lung cancer risk: a preliminary study among Chinese women in Singapore. (2001 Apr)Seow ACarcinogenesis
15127906Maternal smoking and the risk of orofacial clefts: Susceptibility with NAT1 and NAT2 polymorphisms. (2004 Mar)Lammer EJEpidemiology
20568013Effect of NAT2 gene polymorphism on bladder cancer risk in Slovak population. (2011 Feb)Klimcakova LMol Biol Rep
16847422Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma. (2006 Aug)Morton LMPharmacogenet Genomics
9771946Re: Hunter, D.J., Hankinson, S.E., Hough, H. et al. (1997), A prospective study of NAT2 acetylation genotype, cigarette smoking and risk of breast cancer. Carcinogenesis, 18, 2127-2132. (1998 Sep)Morabia ACarcinogenesis
21480221Cytochrome P4501A2 phenotype and bladder cancer risk: The Shanghai bladder cancer study. (2012 Mar 1)Tao LInt J Cancer
8640907Environmental air pollution and DNA adducts in Copenhagen bus drivers--effect of GSTM1 and NAT2 genotypes on adduct levels. (1996 May)Nielsen PSCarcinogenesis
11075868Associations between family history of cancer and genes coding for metabolizing enzymes (United States). (2000 Oct)Slattery MLCancer Causes Control
24092628N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk: results from the EPIC cohort. (2013 Nov)Pesch BCancer Epidemiol Biomarkers Prev
12015038[Relationship between polymorphism of N-acetyltransferase 2 and genetic susceptibility to laryngeal carcinoma]. (2002 Mar)Lei DZhonghua Zhong Liu Za Zhi
11034589Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: impact of smoking on risk. (2000 Nov)Yu MWGut
25422202Association of CYP2E1 and NAT2 polymorphisms with lung cancer susceptibility among Mongolian and Han populations in the Inner Mongolian region. (2014)Zhang JWAsian Pac J Cancer Prev
11725345DNA adducts and human atherosclerotic lesions. (2001 Oct)Binkova BInt J Hyg Environ Health
8375127Acetylation phenotype and cytochrome P450IA2 phenotype are unlikely to be associated with peripheral arterial disease. (1993 Sep)Ilett KFClin Pharmacol Ther
19930190Case-control studies of gene-environment interaction: Bayesian design and analysis. (2010 Sep)Mukherjee BBiometrics
26617241N-Acetyltransferase 2 (NAT2) genetic variation and the susceptibility to noncardiac gastric adenocarcinoma in Taiwan. (2016 Mar)Chang CHJ Chin Med Assoc
17675654Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis. (2007 Oct 1)Sanderson SAm J Epidemiol
11189784[Biomarkers of gentotoxic risk and metabolic polymorphism]. (2000 Sep-Oct)Pavanello SMed Lav
14612556p53 mutations in bladder cancer: evidence for exogenous versus endogenous risk factors. (2003 Nov 1)Schroeder JCCancer Res
16327307Interaction effect in bladder cancer between N-acetyltransferase 2 genotype and alcohol drinking. (2005)Lu CMUrol Int
21254355Smoking, the xenobiotic pathway, and clubfoot. (2011 Jan)Sommer ABirth Defects Res A Clin Mol Teratol
19570260Impact of genetic polymorphisms on the smoking-related risk of periodontal disease: the population-based study SHIP. (2003 Sep 15)Meisel PTob Induc Dis
23628324Genetic polymorphisms of CYP2E1, GST, and NAT2 enzymes are not associated with risk of breast cancer in a sample of Lebanese women. (2013 Jul-Aug)Zgheib NKMutat Res
12163321Differential effect of NAT2 on the association between active and passive smoke exposure and breast cancer risk. (2002 Aug)Chang-Claude JCancer Epidemiol Biomarkers Prev
18026184NAT2 and NER genetic variants and sporadic prostate cancer susceptibility in African Americans. (2008)Hooker SProstate Cancer Prostatic Dis
10471065Polymorphisms in NAT2, CYP2D6, CYP2C19 and GSTP1 and their association with prostate cancer. (1999 Jun)Wadelius MPharmacogenetics
10517994Adverse reproductive outcomes from exposure to environmental mutagens. (1999 Jul 16)Sram RJMutat Res
17535831A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer. (2007 Aug 1)Ochs-Balcom HMAm J Epidemiol
11431340Association of NAT1 and NAT2 polymorphisms to urinary bladder cancer: significantly reduced risk in subjects with NAT1*10. (2001 Jul 1)Cascorbi ICancer Res
16955540Bayesian synthesis of epidemiological evidence with different combinations of exposure groups: application to a gene-gene-environment interaction. (2006 Dec 30)Salanti GStat Med
15226677Chromosomal aberrations in workers exposed to low levels of benzene: association with genetic polymorphisms. (2004 Jul)Kim SYPharmacogenetics
22788240Genetic interaction between NAT2, GSTM1, GSTT1, CYP2E1, and environmental factors is associated with adverse reactions to anti-tuberculosis drugs. (2012 Aug 1)Costa GNMol Diagn Ther
21684175alcohol, smoking, and caffeine in relation to fecundability, with effect modification by NAT2. (2011 Nov)Taylor KCAnn Epidemiol
10389748Association between N-acetyltransferase 2 (NAT2) genetic polymorphism and development of breast cancer in post-menopausal Chinese women in Taiwan, an area of great increase in breast cancer incidence. (1999 Jul 19)Huang CSInt J Cancer
19443378Genetic polymorphisms in CYP1A1, CYP1B1, COMT, GSTP1 and NAT2 genes and association with bladder cancer risk in a French cohort. (2009 May)Fontana LAnticancer Res
10767640Impact of polymorphisms in xeno(endo)biotic metabolism on pattern and frequency of p53 mutations in bladder cancer. (2000 Apr)Martone TMutat Res
15617035N-acetyltransferase 2 gene polymorphism in patients with colorectal carcinoma. (2006 Mar-Apr)Tamer LCell Biochem Funct
12016161Determinants of 4-aminobiphenyl-DNA adducts in bladder cancer biopsies. (2002 May)Airoldi LCarcinogenesis
20197243Smoking (active and passive), N-acetyltransferase 2, and risk of breast cancer. (2010 Apr)Conlon MSCancer Epidemiol
27002914Lifestyle and clinical determinants of skin autofluorescence in a population-based cohort study. (2016 May)van Waateringe RPEur J Clin Invest
9568593Urinary mutagenicity on TA98 and YG1024 Salmonella typhimurium strains after a hamburger meal: influence of GSTM1 and NAT2 genotypes. (1998 Mar)Gabbani GMutagenesis
11535252Risk assessment: the importance of genetic polymorphisms in man. (2001 Oct 1)Knudsen LEMutat Res
15725609Effects of N-acetyl transferase 1 and 2 polymorphisms on bladder cancer risk in Caucasians. (2005 Mar 7)Gu JMutat Res
8287063Correlation between N-acetyltransferase activity and NAT2 genotype in Chinese males. (1993 Oct)Rothman NPharmacogenetics
10635997Investigation of mutant frequency at the HPRT locus and changes in microsatellite sequences in healthy young adults. (1999 Dec 17)Davies MJMutat Res
8903261Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk. (1996 Nov 13)Ambrosone CBJAMA
12877350Impact of N-acetyltransferase polymorphism (NAT2) in hepatocellular carcinoma (HCC)--an investigation in a department of surgical medicine. (2003 Jun)Farker KExp Toxicol Pathol
9731715N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk. (1998 Aug)Bouchardy CPharmacogenetics
10359544Colorectal cancer: molecules and populations. (1999 Jun 2)Potter JDJ Natl Cancer Inst
24791559[The relationship between passive smoking, breast cancer risk and n-acetyltransferase 2 (NAT2)]. (2014 Mar-Apr)Avraham ZHarefuah
8761425GSTM1 and NAT2 genotypes and urinary mutagens in coke oven workers. (1996 Aug)Gabbani GCarcinogenesis
12835615NAT2 slow acetylation and GSTM1 null genotypes may increase postmenopausal breast cancer risk in long-term smoking women. (2003 Jul)van der Hel OLPharmacogenetics
27582327The Effect of Yokukansan, a Traditional Herbal Preparation Used for the Behavioral and Psychological Symptoms of Dementia, on the Drug-Metabolizing Enzyme Activities in Healthy Male Volunteers. (2016)Soraoka HBiol Pharm Bull
18159984Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking. (2007 Jul-Sep)Yoshida KAsian Pac J Cancer Prev
16615268[Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and N-acetyltransferase 2 polymorphisms and the risk of gastric cancer]. (2006 Mar)Hong SHJ Prev Med Public Health
15055296Cytogenetic biomarkers. (2004)Norppa HIARC Sci Publ
28952301Distribution and Role of N-acetyltransferase 2 Genetic Polymorphisms in Bladder Cancer Risk in a Lebanese Population (2017 Sep 27)Nasr RAsian Pac J Cancer Prev
11470992Modulation of DNA and protein adducts in smokers by genetic polymorphisms in GSTM1,GSTT1, NAT1 and NAT2. (2001 Jul)Godschalk RWPharmacogenetics
26202054Interaction between smoking history and gene expression levels impacts survival of breast cancer patients. (2015 Aug)Andres SABreast Cancer Res Treat
17026750Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and women. (2006 Oct 6)McGrath MBMC Cancer
19380028Combined effect of smoking and inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1 on bladder cancer in a Tunisian population. (2009 Apr 15)Rouissi KCancer Genet Cytogenet
21081473Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia. (2011 Feb)Wang HCarcinogenesis
11846845Association between bone loss in periodontal disease and polymorphism of N-acetyltransferase (NAT2). (2002 Jan)Kocher TJ Clin Periodontol
16380991Fruit consumption reduces the effect of smoking on bladder cancer risk. The Belgian case control study on bladder cancer. (2006 May 15)Kellen EInt J Cancer
11482447Tobacco use and occupational exposure to carcinogens, but not N-acetyltransferase 2 genotypes are major risk factors for bladder cancer in the Japanese. (2001 Jun)Kontani KUrol Res
26585839Association Between N-acetyltransferase 2 Polymorphism and Bladder Cancer Risk: Results From Studies of the Past Decade and a Meta-Analysis. (2016 Apr)Wu HClin Genitourin Cancer
18986377Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan. (2010 Feb)Maruyama KAlcohol Clin Exp Res
28693112Association of prenatal passive smoking and metabolic gene polymorphisms with child growth from birth to 3years of age in the Hokkaido Birth Cohort Study on Environment and Children's Health. (2017 Dec 15)Braimoh TSSci Total Environ
11107547[Prevention of renal carcinoma: the nutri-genetic approach]. (2000)Junien CJ Soc Biol
18449058Maternal smoking and oral clefts: the role of detoxification pathway genes. (2008 Jul)Lie RTEpidemiology
8752158Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk. (1996 Sep 1)Brockmoller JCancer Res
8781741Predictors of N-acetyltransferase activity: should caffeine phenotyping and NAT2 genotyping be used interchangeably in epidemiological studies? (1996 Jun)Le Marchand LCancer Epidemiol Biomarkers Prev
19692670N-acetyltransferase 2 genotype modification of active cigarette smoking on breast cancer risk among hispanic and non-hispanic white women. (2009 Nov)Baumgartner KBToxicol Sci
24151610Polymorphisms in the human cytochrome P450 and arylamine N-acetyltransferase: susceptibility to head and neck cancers. (2013)Khlifi RBiomed Res Int
29267235Relationship between Telomere Length, Genetic Traits and Environmental/Occupational Exposures in Bladder Cancer Risk by Structural Equation Modelling. (2017 Dec 21)Pavanello SInt J Environ Res Public Health
19549810Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study. (2009 Jul)Nothlings UCancer Epidemiol Biomarkers Prev
15548945Glutathione S-transferase (GST) M1, T1 and N-acetyltransferase 2 (NAT2) polymorphisms and urothelial cancer risk with tobacco smoking. (2004 Dec)Tsukino HEur J Cancer Prev
8895478Lack of association between the polyadenylation polymorphism in the NAT1 (acetyltransferase 1) gene and colorectal adenomas. (1996 Oct)Probst-Hensch NMCarcinogenesis
27883249N-acetyl transferase 2/environmental factors and their association as a modulating risk factor for sporadic colon and rectal cancer. (2017 Sep)Procopciuc LMJ Clin Lab Anal
10333536Micronuclei in blood lymphocytes and genetic polymorphism for GSTM1, GSTT1 and NAT2 in pesticide-exposed greenhouse workers. (1999 May 17)Falck GCMutat Res
29589062N-Acetyltransferase-2 (NAT2) phenotype is influenced by genotype-environment interaction in Ethiopians. (2018 Mar 27)Aklillu EEur J Clin Pharmacol
9865425NAT2, GSTM-1, cigarette smoking, and risk of colon cancer. (1998 Dec)Slattery MLCancer Epidemiol Biomarkers Prev
22835378Cyanamide-mediated Inhibition of N-acetyltransferase 1. (2012 Dec 8)Dierolf DToxicology
22027651Genetic polymorphisms of xenobiotic-metabolizing enzymes influence the risk of pulmonary emphysema. (2011 Dec)Kukkonen MKPharmacogenet Genomics
9472690Increased frequency of wild-type arylamine-N-acetyltransferase allele NAT2*4 homozygotes in Portuguese patients with colorectal cancer. (1998 Jan)Gil JPCarcinogenesis
23491024Rapid and intermediate N-acetylators are less susceptible to oxidative damage among 4,4'-methylenebis(2-chloroaniline) (MBOCA)-exposed workers. (2013 Jul)Lin ISInt J Hyg Environ Health
26700672Active cigarette smoking and the risk of breast cancer at the level of N-acetyltransferase 2 (NAT2) gene polymorphisms. (2016 Jun)Kasajova PTumour Biol
10607733GSTM1 and NAT2 polymorphisms in operable and non-operable lung cancer patients. (2000 Jan)Hou SMCarcinogenesis
11059519Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer. (2000 Sep)Kiyohara CJ Epidemiol
14646291Effects of genetic polymorphisms in metabolic enzymes on the relationships between 8-hydroxydeoxyguanosine levels in human leukocytes and urinary 1-hydroxypyrene and 2-naphthol concentrations. (2003 May)Kim YDJ Occup Health
20972438A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. (2010 Nov)Rothman NNat Genet
12584178Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer. (2003 Feb)Barrett JHCarcinogenesis
17006723NAT2, meat consumption and colorectal cancer incidence: an ecological study among 27 countries. (2006 Nov)Ognjanovic SCancer Causes Control
17477782NAT2 and CYP1A2 polymorphisms and lung cancer risk in relation to smoking status. (2007 Jan-Mar)Osawa YAsian Pac J Cancer Prev
9395212A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer. (1997 Nov)Hunter DJCarcinogenesis
22588343A meta-analysis of the relationship between NAT2 polymorphism and colorectal cancer susceptibility. (2012)Liu HMedicina (Kaunas)
21352246Polymorphism of N-acetyltransferase 2 gene and the susceptibility to alcoholic liver cirrhosis: interaction with smoking. (2011 Jul)Yang KCAlcohol Clin Exp Res
12611196[Clinical relevance of N-acetyltransferase type 2 (NAT2) genetic polymorphism]. (2002 Sep-Oct)Furet YTherapie
23536561Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer. (2013 Apr 1)Garcia-Closas MCancer Res
10469638NAT2 slow acetylator genotype is associated with increased risk of lung cancer among non-smoking Chinese women in Singapore. (1999 Sep)Seow ACarcinogenesis
10840461Polymorphisms of N-acetyltransferase 2, glutathione S-transferase mu and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis. (2000 Jul)Kim WJJ Urol
24922697NAT2, XRCC1 and hOGG1 polymorphisms, cigarette smoking, alcohol consumption and risk of upper aerodigestive tract cancer. (2014 Jun)Marques CRAnticancer Res
17063266CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population. (2007 Sep)Sillanpaa PBreast Cancer Res Treat
15122594GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population. (2004 Jul 1)Hung RJInt J Cancer
26045716Genetic susceptibility in childhood acute leukaemias: a systematic review. (2015)Brisson GDEcancermedicalscience
18258609A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. (2008 Jun)Zienolddiny SCarcinogenesis
20180012NAT2 polymorphisms combining with smoking associated with breast cancer susceptibility: a meta-analysis. (2010 Oct)Zhang JBreast Cancer Res Treat
9610785Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer risk. (1998 May)Millikan RCCancer Epidemiol Biomarkers Prev
24445297Commentary on "common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer." Garcia-Closas M, Rothman N, Figueroa JD, Prokunina-Olsson L, Han SS, Baris D, Jacobs EJ, Malats N, De Vivo I, Albanes D, Purdue MP, Sharma S, Fu YP, Kogevinas M, Wang Z, Tang W, Tardon A, Serra C, Carrato A, Garcia-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Andriole G Jr., Grubb R 3rd, Black A, Gapstur SM, Thun M, Diver WR, Weinstein SJ, Virtamo J, Hunter DJ, Caporaso N, Landi MT, Hutchinson A, Burdett L, Jacobs KB, Yeager M, Fraumeni JF Jr., Chanock SJ, Silverman DT, Chatterjee N, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.: Cancer Res 2013;73(7):2211-20 [Epub 2013 Mar 27]. (2014 Feb)Scherr DSUrol Oncol
19838317Testing in semiparametric models with interaction, with applications to gene-environment interactions. (2009 Jan 1)Maity AJ R Stat Soc Series B Stat Methodol
15700302Prospective study of N-acetyltransferase-2 genotypes, meat intake, smoking and risk of colorectal cancer. (2005 Jul 1)Chan ATInt J Cancer
12195642GSTM-1 and NAT2 and genetic alterations in colon tumors. (2002 Aug)Slattery MLCancer Causes Control
11872636Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer. (2002 Feb)Firozi PFCarcinogenesis
11219770Differential interactions between GSTM1 and NAT2 genotypes on aromatic DNA adduct level and HPRT mutant frequency in lung cancer patients and population controls. (2001 Feb)Hou SMCancer Epidemiol Biomarkers Prev
29600472Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: a pooled analysis from the childhood Leukemia International Consortium. (2018 Jun)Milne ECancer Causes Control
10585581Inherited polymorphism in the N-acetyltransferase 1 (NAT1) and 2 (NAT2) genes and susceptibility to gastric and colorectal adenocarcinoma. (2000 Jan 1)Katoh TInt J Cancer
15225898N-acetyltransferase 2 (NAT2) genotypes, cigarette smoking, and the risk of breast cancer. (2004)Alberg AJCancer Detect Prev
12351160Well-done red meat, metabolic phenotypes and colorectal cancer in Hawaii. (2002 Sep 30)Le Marchand LMutat Res
11603126N-acetyltransferase 2 phenotype in painters with bladder cancer and controls. (2001 Sep)Golka KAnn Acad Med Singapore
16112301NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. (2005 Aug 20-26)Garcia-Closas MLancet
19643819Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population. (2009 Oct)Imaizumi TCarcinogenesis
16906563Risk of limb deficiency defects associated with NAT1, NAT2, GSTT1, GSTM1, and NOS3 genetic variants, maternal smoking, and vitamin supplement intake. (2006 Sep 15)Carmichael SLAm J Med Genet A
21989592Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans. (2012 Mar)Mikuls TRArthritis Rheum
27509179Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2. (2016 Dec)Matthaei JClin Pharmacol Ther
8665871Cytogenetic monitoring of occupational exposure to pesticides: characterization of GSTM1, GSTT1, and NAT2 genotypes. (1996)Scarpato REnviron Mol Mutagen
28259080Passive smoking and influenza-like illness in housewives: A perspective of gene susceptibility. (2017 Jun)Wang BChemosphere
19809881Genetic variation in N-acetyltransferases 1 and 2, cigarette smoking, and risk of non-Hodgkin lymphoma. (2010 Jan)Kilfoy BACancer Causes Control
9810147Effects of genetic polymorphism of metabolic enzymes, nutrition, and lifestyle factors on DNA adduct formation in lymphocytes. (1998 Oct)Wang YInd Health
29071579Passive smoking, NAT2 polymorphism, and breast cancer risk in Israeli Arab women: a case-control study. (2018 Mar)Regev-Avraham ZBreast Cancer
21097530Influence of GSTM1, GSTT1, GSTP1, NAT1, NAT2, EPHX1, MTR and MTHFR polymorphism on chromosomal aberration frequencies in human lymphocytes. (2011 Mar)Skjelbred CFCarcinogenesis