Gene: GNPDA1

10007
GNP1|GNPDA|GNPI|GPI|HLN
glucosamine-6-phosphate deaminase 1
protein-coding
5q31.3
Ensembl:ENSG00000113552 MIM:601798 Vega:OTTHUMG00000129657 UniprotKB:P46926
NC_000005.10
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.411e-1 (AD)  3.253e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05616995chr5:141393361GNPDA1Promoter2.940e-5Alcohol use disorders26763658
cg06866033chr5:141391951GNPDA13.600e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IFT460.953
MICU10.952
UBE2Q10.947
RRAGA0.947
GOT20.947
PRPF190.947
DDX240.946
WIPI20.945
VPS26B0.944
PPP2R5D0.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.662
OR4F29-0.604
TFPI2-0.405
IL18RAP-0.392
KLRB1-0.39
C9orf153-0.382
RAI14-0.375
FZD10-0.366
ASB4-0.363
MTRNR2L6-0.344

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02379Beta-D-GlucoseSmall Molecule492-61-5ExperimentalTarget
DB024452-Deoxy-2-Amino Glucitol-6-PhosphateSmall MoleculeExperimentalTarget
DB03951N-acetyl-D-glucosamine-6-phosphateSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GNPDA1 mRNA"21354444|2890350
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GNPDA1 mRNA"23994337
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GNPDA1 mRNA"25380136
D000082AcetaminophenAcetaminophen results in increased expression of GNPDA1 mRNA29067470
D020106AcrylamideAcrylamide results in increased expression of GNPDA1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GNPDA1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GNPDA1 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of GNPDA1 mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of GNPDA1 mRNA28522335
D016718Arachidonic AcidArachidonic Acid results in decreased expression of GNPDA1 mRNA16704987
D001151ArsenicArsenic results in increased methylation of GNPDA1 promoter21291286
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of GNPDA1 mRNA"18687144
C547126AZM551248AZM551248 results in increased expression of GNPDA1 mRNA22323515
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of GNPDA1 mRNA23994337
C006780bisphenol Abisphenol A results in increased expression of GNPDA1 mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of GNPDA1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of GNPDA1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GNPDA1 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GNPDA1 protein24527689
C100187chloropicrinchloropicrin results in increased expression of GNPDA1 mRNA28476498
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of GNPDA1 mRNA28472532
D002994ClofibrateClofibrate results in increased expression of GNPDA1 mRNA25270620
D016572CyclosporineCyclosporine results in decreased expression of GNPDA1 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of GNPDA1 mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GNPDA1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GNPDA1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GNPDA1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GNPDA1 mRNA27392435
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of GNPDA1 mRNA25380136
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GNPDA1 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of GNPDA1 mRNA21126777
C027618fructose-6-phosphateGNPDA1 protein results in increased chemical synthesis of fructose-6-phosphate12616532
C001293glucosamine 6-phosphateGNPDA1 protein results in increased metabolism of glucosamine 6-phosphate12616532
C492448ICG 001ICG 001 results in increased expression of GNPDA1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GNPDA1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GNPDA1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GNPDA1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GNPDA1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of GNPDA1 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GNPDA1 mRNA23649840
D009151Mustard GasMustard Gas results in increased expression of GNPDA1 mRNA12884408
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GNPDA1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GNPDA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GNPDA1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GNPDA1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of GNPDA1 mRNA25380136
D009532NickelNickel results in decreased expression of GNPDA1 mRNA23195993
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GNPDA1 protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of GNPDA1 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of GNPDA1 mRNA17426115|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of GNPDA1 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of GNPDA1 mRNA28903501
C010327salinomycinsalinomycin results in decreased expression of GNPDA1 mRNA19682730
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GNPDA1 mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of GNPDA1 mRNA24612858
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GNPDA1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GNPDA1 mRNA15800033|2399433
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GNPDA1 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of GNPDA1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GNPDA1 protein22595367
C034613triacsin Ctriacsin C results in decreased expression of GNPDA1 mRNA16704987
C012589trichostatin Atrichostatin A results in increased expression of GNPDA1 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of GNPDA1 mRNA19042947
D014520UrethaneUrethane results in decreased expression of GNPDA1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of GNPDA1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GNPDA1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GNPDA1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004342glucosamine-6-phosphate deaminase activity-IBA21873635  
GO:0004342glucosamine-6-phosphate deaminase activity-IMP9438414  
GO:0004342glucosamine-6-phosphate deaminase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IEA-  
GO:0006043glucosamine catabolic process-IMP9438414  
GO:0006043glucosamine catabolic process-TAS-  
GO:0006044N-acetylglucosamine metabolic process-IEA-  
GO:0006046N-acetylglucosamine catabolic process-IBA21873635  
GO:0006048UDP-N-acetylglucosamine biosynthetic process-IBA21873635  
GO:0006091generation of precursor metabolites and energy-IMP9438414  
GO:0007338single fertilization-TAS9714720  
GO:0019262N-acetylneuraminate catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  19199708  
KEGG ID KEGG Term
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70171GlycolysisTAS
R-HSA-70326Glucose metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal