Gene: TANK

10010
I-TRAF|ITRAF|TRAF2
TRAF family member associated NFKB activator
protein-coding
2q24.2
Ensembl:ENSG00000136560 MIM:603893 Vega:OTTHUMG00000132037 UniprotKB:Q92844
NC_000002.12
PubMed
0   ANCO-SNPs
ND|AD
16   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.366e-1 (AD)  4.552e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19914919chr2:161992878TANKPromoter1.531e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMED70.905
CD1640.89
LMAN10.863
TBC1D150.862
FNDC3A0.861
MIER10.859
BET10.854
TNPO10.854
RB10.851
SP30.851

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.607
OR4F29-0.574
RNF223-0.233
PTGDR2-0.222
RSPO1-0.215
MTRNR2L6-0.189
MTRNR2L9-0.181
REM1-0.18
MTRNR2L10-0.18
SPRR2D-0.179

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TANK mRNA28329830
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of TANK mRNA12419474
D000082AcetaminophenAcetaminophen results in decreased expression of TANK mRNA17585979
D000111AcetylcysteineAcetylcysteine results in decreased expression of TANK mRNA16084531
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TANK mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TANK mRNA24449571
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of TANK mRNA19962721
D001151ArsenicArsenic results in decreased expression of TANK mRNA19962721
C006632arsenic trioxidearsenic trioxide results in increased expression of TANK mRNA19730151
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased methylation of TANK promoter28329817
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TANK mRNA22228805
D004958EstradiolESR2 protein affects the reaction [Estradiol results in increased expression of TANK mRNA]14699072
D004958EstradiolEstradiol affects the expression of TANK mRNA14699072
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of TANK mRNA20404318
D004958EstradiolEstradiol results in increased expression of TANK mRNA17010207
C006780bisphenol Abisphenol A affects the expression of TANK mRNA21786754
C006780bisphenol Abisphenol A affects the expression of TANK mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of TANK mRNA17553608
D000069286BortezomibBortezomib results in increased expression of TANK mRNA20977926
D002220CarbamazepineCarbamazepine affects the expression of TANK mRNA24752500
D002706ChlordanChlordan results in decreased expression of TANK mRNA23153324
D003703DemecolcineDemecolcine results in increased expression of TANK mRNA23649840
D002945CisplatinCisplatin results in increased expression of TANK protein16803524
D004008DiclofenacDiclofenac affects the expression of TANK mRNA24752500
C000944dicrotophosdicrotophos results in decreased expression of TANK mRNA28302478
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TANK mRNA17010207
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of TANK mRNA27638505
D004391DustDust results in increased expression of TANK mRNA17805423
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of TANK mRNA16084531
D000431EthanolEthanol results in decreased expression of TANK mRNA16098508
D000431EthanolEthanol results in increased expression of TANK mRNA23273579
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TANK mRNA23649840
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TANK mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TANK mRNA28329830
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of TANK mRNA19962721
D005459FluoridesFluorides results in decreased expression of TANK mRNA19962721
D005472FluorouracilFluorouracil results in increased expression of TANK protein16803524
D005485FlutamideFlutamide results in increased expression of TANK mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of TANK mRNA23649840
D005839GentamicinsGentamicins results in increased expression of TANK mRNA22061828
D017313FenretinideFenretinide results in decreased expression of TANK mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of TANK mRNA12419474
C492448ICG 001ICG 001 results in increased expression of TANK mRNA26191083
D000068877Imatinib MesylateImatinib Mesylate results in increased expression of TANK mRNA21935477
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TANK mRNA25613284
D007530IsofluraneIsoflurane results in decreased expression of TANK mRNA16978161
C544151jinfukangjinfukang results in decreased expression of TANK mRNA27392435
C410337K 7174K 7174 results in increased expression of TANK mRNA24086573
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TANK mRNA"19264136
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Simvastatin] results in increased expression of TANK mRNA15665042
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TANK mRNA26378955
D008748MethylcholanthreneMethylcholanthrene results in increased expression of TANK mRNA23273579
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TANK mRNA23649840
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TANK mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TANK mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TANK mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TANK mRNA"25554681
C474055octylphenoloctylphenol results in increased expression of TANK mRNA17010207
C507134ON 01910ON 01910 results in increased expression of TANK mRNA22351695
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TANK mRNA25729387
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TANK mRNA23948077
D010634PhenobarbitalPhenobarbital results in increased expression of TANK mRNA23273579
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TANK mRNA21540303
D019821Simvastatin[Lipopolysaccharides co-treated with Simvastatin] results in increased expression of TANK mRNA15665042
C017947sodium arsenitesodium arsenite results in increased expression of TANK mRNA12016162
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TANK mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TANK mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TANK mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of TANK mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TANK mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of TANK mRNA"19682533
D014212TretinoinSOX11 protein promotes the reaction [Tretinoin results in increased expression of TANK mRNA]17055661
D014520UrethaneUrethane results in increased expression of TANK mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of TANK gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TANK mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of TANK mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TANK gene25560391
D014750VincristineVincristine results in decreased expression of TANK mRNA23649840
D014750VincristineVincristine results in increased expression of TANK mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of TANK mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004843thiol-dependent ubiquitin-specific protease activitycontributes_toIMP25861989  
GO:0005515protein binding-IPI12005438  14743216  17500595  17568778  18307994  20562859  
21212807  21784977  21903422  21931555  21988832  24008843  
25416956  25852190  25861989  26638075  
GO:0031625ubiquitin protein ligase binding-IPI11279055  
GO:0035800deubiquitinase activator activity-IMP25861989  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0006974cellular response to DNA damage stimulus-IMP25861989  
GO:0007165signal transduction-TAS8710854  
GO:0007249I-kappaB kinase/NF-kappaB signaling-IBA21873635  
GO:0007249I-kappaB kinase/NF-kappaB signaling-IEA-  
GO:0016032viral process-IEA-  
GO:0035666TRIF-dependent toll-like receptor signaling pathway-TAS-  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-IMP25861989  
GO:0071347cellular response to interleukin-1-IMP25861989  
GO:0071356cellular response to tumor necrosis factor-IMP25861989  
GO:0071479cellular response to ionizing radiation-IMP25861989  
GO:1903003positive regulation of protein deubiquitination-IMP25861989  
GO:2000158positive regulation of ubiquitin-specific protease activity-IMP25861989  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0032991protein-containing complex-IDA25861989  
KEGG ID KEGG Term
hsa04622RIG-I-like receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-9013973TICAM1-dependent activation of IRF3/IRF7TAS
R-HSA-933541TRAF6 mediated IRF7 activationTAS
R-HSA-936964Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17049956Anxiolytic effects of nicotine in zebrafish. (2007 Jan 30)Levin EDPhysiol Behav
22266470Animated bird silhouette above the tank: acute alcohol diminishes fear responses in zebrafish. (2012 Apr 1)Luca RMBehav Brain Res
9482088A history of Dwight D. Eisenhower's oral health. (1995 Nov)Mixson JMJ Hist Dent
27633767Flavourings significantly affect inhalation toxicity of aerosol generated from electronic nicotine delivery systems (ENDS). (2016 Nov)Leigh NJTob Control
23234609Airway symptoms and lung function in the local population after the oil tank explosion in Gulen, Norway. (2012 Dec 12)Granslo JTBMC Pulm Med
25136935Subjective Health Complaints Among Workers in the Aftermath of an Oil Tank Explosion. (2015)Tjalvin GArch Environ Occup Health
21255611Differences of acute versus chronic ethanol exposure on anxiety-like behavioral responses in zebrafish. (2011 Jun 1)Mathur PBehav Brain Res
23658154The novel gene tank, a tumor suppressor homolog, regulates ethanol sensitivity in Drosophila. (2013 May 8)Devineni AVJ Neurosci
25129195Unconventional materials and substances used in water pipe (narghile) by smokers in central western region of Saudi Arabia. (2014 Aug)Baboor ASSaudi Med J
28657413Dynamic measurement of newly formed carbonyl compounds in vapors from electronic cigarettes. (2017 Apr)Sala CEur J Mass Spectrom (Chichester)
20439032BCAN Think Tank session 1: Overview of risks for and causes of bladder cancer. (2010 May-Jun)Zlotta ARUrol Oncol
20439034BCAN Think Tank session 3: Prevention of bladder cancer. (2010 May-Jun)Lerner SPUrol Oncol
28082323Second Generation Electronic Nicotine Delivery System Vape Pen Exposure Generalizes as a Smoking Cue. (2018 Jan 5)King ACNicotine Tob Res
23551515'Vaping' profiles and preferences: an online survey of electronic cigarette users. (2013 Jun)Dawkins LAddiction
23301120Smoking in diabetic nephropathy: sparks in the fuel tank? (2012 Dec 15)Chakkarwar VAWorld J Diabetes
3823805Impaired odor perception in tank cleaners. (1986 Dec)Ahlstrom RScand J Work Environ Health