Gene info: ID 10013

Gene: HDAC6

GENE ID: 10013

Synonyms: CPBHM|HD6|JM21|PPP1R90

Description: histone deacetylase 6

Gene type: protein-coding

Location: Xp11.23

dbXrefs: Ensembl:ENSG00000094631 MIM:300272 Vega:OTTHUMG00000034496 UniprotKB:Q9UBN7

RefSeq: NG_012560.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SNRNP70	0.925
WDR59	0.92
MAU2	0.918
EXOSC10	0.917
MAN2C1	0.916
ZNF76	0.915
DVL2	0.915
KAT2A	0.914
NUMA1	0.913
AKT2	0.911

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.68
OR4F29	-0.652
MTRNR2L6	-0.281
MTRNR2L9	-0.278
KRTAP1-1	-0.246
MTRNR2L10	-0.241
TTLL10-AS1	-0.236
HMHB1	-0.225
OR4F16	-0.222
KLRB1	-0.216

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02546	Vorinostat	Small Molecule	149647-78-9	Approved\|Investigational	Target
DB05223	Pracinostat	Small Molecule		Investigational	Target
DB06176	Romidepsin	Small Molecule	128517-07-7	Approved\|Investigational	Target
DB05015	Belinostat	Small Molecule	866323-14-0	Approved\|Investigational	Target
DB06603	Panobinostat	Small Molecule	404950-80-7	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of HDAC6 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of HDAC6 mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC6 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC6 mRNA"	27188386
D020106	Acrylamide	Acrylamide results in increased expression of HDAC6 mRNA	28959563
D000242	Cyclic AMP	HDAC6 protein affects the abundance of Cyclic AMP	28887310
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HDAC6 mRNA	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HDAC6 mRNA	16483693
C006780	bisphenol A	bisphenol A results in increased expression of HDAC6 mRNA	26546977
D000069286	Bortezomib	HDAC6 results in decreased susceptibility to Bortezomib	16585204
C027561	butylbenzyl phthalate	butylbenzyl phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]	22552774
C027561	butylbenzyl phthalate	[butylbenzyl phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]] which results in increased expression of HDAC6 mRNA	22552774\|2255277
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in increased expression of HDAC6 mRNA	22552774
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in increased expression of HDAC6 protein	22552774
C027561	butylbenzyl phthalate	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate affects the localization of CTNNB1 protein]	22552774
C027561	butylbenzyl phthalate	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]	22552774
C027561	butylbenzyl phthalate	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate results in decreased expression of KRT7 protein]	22552774
C027561	butylbenzyl phthalate	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of VIM protein]	22552774
C027561	butylbenzyl phthalate	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of AKT1 protein]	22552774
C027561	butylbenzyl phthalate	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of GSK3B protein]	22552774
C027561	butylbenzyl phthalate	HDAC6 results in increased susceptibility to butylbenzyl phthalate	22552774
C027561	butylbenzyl phthalate	TFAP2A mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of HDAC6 protein]	22552774
D002087	Butyrates	Butyrates results in decreased activity of HDAC6 protein	15930892
D020148	Butyric Acid	Butyric Acid promotes the reaction [SRSF2 protein binds to HDAC6 protein]	21555914
D020148	Butyric Acid	HDAC6 protein promotes the reaction [Butyric Acid results in increased expression of SRSF2 protein]	21555914
C584509	C646 compound	C646 compound results in decreased activity of HDAC6 protein	26718586
D019256	Cadmium Chloride	Cadmium Chloride affects the localization of HDAC6 protein	18261755
D019256	Cadmium Chloride	Cadmium Chloride affects the localization of HDAC6 protein	18261755
D019256	Cadmium Chloride	Cadmium Chloride affects the localization of HDAC6 protein	18261755
D019256	Cadmium Chloride	Cadmium Chloride affects the localization of HDAC6 protein	18261755
D002251	Carbon Tetrachloride	Carbon Tetrachloride deficiency inhibits the reaction [Carbon Tetrachloride results in increased expression of HDAC6 mRNA]	27396813
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of HDAC6 mRNA	27396813
C006963	chlamydocin	chlamydocin analog results in decreased activity of HDAC6 protein	16439135
D003474	Curcumin	Curcumin analog results in decreased expression of HDAC6 mRNA	26409325
D016572	Cyclosporine	Cyclosporine results in decreased expression of HDAC6 mRNA	19770486
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of HDAC6 mRNA	23640034
D003993	Dibutyl Phthalate	Dibutyl Phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]	22552774
D003993	Dibutyl Phthalate	[Dibutyl Phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]] which results in increased expression of HDAC6 mRNA	22552774\|2255277
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of HDAC6 mRNA	22552774
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of HDAC6 protein	22552774
D003993	Dibutyl Phthalate	HDAC6 mutant form inhibits the reaction [Dibutyl Phthalate affects the localization of CTNNB1 protein]	22552774
D003993	Dibutyl Phthalate	HDAC6 mutant form inhibits the reaction [Dibutyl Phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]	22552774
D003993	Dibutyl Phthalate	HDAC6 mutant form inhibits the reaction [Dibutyl Phthalate results in decreased expression of KRT7 protein]	22552774
D003993	Dibutyl Phthalate	HDAC6 mutant form inhibits the reaction [Dibutyl Phthalate results in increased expression of VIM protein]	22552774
D003993	Dibutyl Phthalate	HDAC6 mutant form inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of AKT1 protein]	22552774
D003993	Dibutyl Phthalate	HDAC6 mutant form inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of GSK3B protein]	22552774
D003993	Dibutyl Phthalate	HDAC6 results in increased susceptibility to Dibutyl Phthalate	22552774
D003993	Dibutyl Phthalate	TFAP2A mutant form inhibits the reaction [Dibutyl Phthalate results in increased expression of HDAC6 protein]	22552774
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of HDAC6 mRNA	17361019\|2126653
D002945	Cisplatin	HDAC6 protein promotes the reaction [Cisplatin results in increased expression of SRSF2 protein]	21157427
D004041	Dietary Fats	Dietary Fats results in increased expression of HDAC6 mRNA	18042831
D004317	Doxorubicin	Doxorubicin results in decreased expression of HDAC6 mRNA	28865727
D004726	Endosulfan	Endosulfan results in decreased expression of HDAC6 mRNA	29054638
D004726	Endosulfan	Endosulfan results in decreased expression of HDAC6 protein	29054638
C031818	enterotoxin B, staphylococcal	"enterotoxin B, staphylococcal results in decreased expression of HDAC6 mRNA"	24200994
C031818	enterotoxin B, staphylococcal	"indole-3-carbinol inhibits the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC6 mRNA]"	24200994
C118739	entinostat	entinostat results in decreased activity of HDAC6 protein	25699604
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of HDAC6 mRNA	17555576
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HDAC6 mRNA	17942748
D018120	Finasteride	Finasteride results in increased expression of HDAC6 mRNA	24136188
D019833	Genistein	Genistein results in decreased expression of HDAC6 mRNA	21048042
C055305	ginsenoside Rh2	ginsenoside Rh2 results in decreased expression of HDAC6 protein	26482938
D017313	Fenretinide	Fenretinide results in increased expression of HDAC6 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of HDAC6 mRNA	20044591
D006997	Hypochlorous Acid	Hypochlorous Acid results in decreased expression of HDAC6 mRNA	19376150
C016517	indole-3-carbinol	"indole-3-carbinol inhibits the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC6 mRNA]"	24200994
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HDAC6 mRNA	25613284
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HDAC6 mRNA	25613284
C544151	jinfukang	jinfukang results in increased expression of HDAC6 mRNA	27392435
C527895	largazole	largazole results in decreased activity of HDAC6 protein	21936551
C013099	mancozeb	mancozeb results in decreased activity of HDAC6 protein	21251949
D008344	Maneb	Maneb results in decreased activity of HDAC6 protein	21251949
D008694	Methamphetamine	Methamphetamine results in decreased expression of HDAC6 mRNA	25452209
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of HDAC6 mRNA	26011545
D008825	Miconazole	Miconazole results in increased expression of HDAC6 mRNA	22262564
C406082	monomethylarsonous acid	[vorinostat co-treated with monomethylarsonous acid] results in decreased expression of HDAC6 mRNA	23891734
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of HDAC6 mRNA"	25554681
C051752	nefazodone	nefazodone results in increased expression of HDAC6 mRNA	24136188
D000073878	Palm Oil	Palm Oil results in increased expression of HDAC6 mRNA	18042831
D010634	Phenobarbital	Phenobarbital affects the expression of HDAC6 mRNA	19159669
C006253	pirinixic acid	pirinixic acid results in increased expression of HDAC6 mRNA	23811191
C008971	polymarcine	polymarcine results in decreased activity of HDAC6 protein	21251949
C087123	romidepsin	romidepsin results in decreased activity of HDAC6 protein	25699604
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of HDAC6 mRNA	23623845
C017947	sodium arsenite	HDAC6 protein affects the susceptibility to sodium arsenite	22367689
C017947	sodium arsenite	sodium arsenite affects the localization of HDAC6 protein	22367689
D053260	Soot	Soot results in increased expression of HDAC6 mRNA	26551751
C471405	sorafenib	sorafenib results in decreased expression of HDAC6 mRNA	26409325
C016766	sulforafan	HDAC6 protein inhibits the reaction [sulforafan results in decreased expression of AR protein]	19805354
C016766	sulforafan	sulforafan results in decreased activity of HDAC6 protein	19805354
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of HDAC6 mRNA"	26680231
D013629	Tamoxifen	Tamoxifen affects the expression of HDAC6 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HDAC6 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in increased expression of HDAC6 mRNA	19465110
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HDAC6 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HDAC6 mRNA	26290441
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HDAC6 mRNA	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HDAC6 mRNA	22493514
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HDAC6 mRNA	25613284
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HDAC6 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in increased expression of HDAC6 protein	24648495
C067071	trapoxin B	trapoxin B results in decreased activity of HDAC6 protein	15930892
C012589	trichostatin A	trichostatin A results in decreased activity of HDAC6 protein	15930892
C012589	trichostatin A	trichostatin A results in decreased activity of HDAC6 protein	25699604
C000602704	UF010 compound	UF010 compound results in decreased activity of HDAC6 protein	25699604
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC6 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of HDAC6 mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid results in increased methylation of HDAC6 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of HDAC6 gene	25560391
C111237	vorinostat	[vorinostat co-treated with monomethylarsonous acid] results in decreased expression of HDAC6 mRNA	23891734
C111237	vorinostat	vorinostat results in decreased activity of HDAC6 protein	15930892
C111237	vorinostat	vorinostat results in decreased activity of HDAC6 protein	17988634\|2569960
D015032	Zinc	Zinc binds to and results in increased activity of HDAC6 protein	16439135

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	24413532
GO:0003779	actin binding	-	IEA	-
GO:0004407	histone deacetylase activity	-	IDA	10220385
GO:0004407	histone deacetylase activity	-	IMP	23322205
GO:0005515	protein binding	-	IPI	12024216 12354939 16919237 17872950 19033385 19081074 19167333 19893491 20029029 21532619 21847094 21952047 22193721 22645275 24658140 24687993 25422469 27556504
GO:0008013	beta-catenin binding	-	IPI	18356165
GO:0008017	microtubule binding	-	IDA	19228685
GO:0008017	microtubule binding	-	ISS	-
GO:0008270	zinc ion binding	-	IEA	-
GO:0019899	enzyme binding	-	ISS	11861901
GO:0031593	polyubiquitin modification-dependent protein binding	-	IDA	14675537
GO:0031625	ubiquitin protein ligase binding	-	IPI	21753002
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	-	IEA	-
GO:0042826	histone deacetylase binding	-	IPI	12620231
GO:0042903	tubulin deacetylase activity	-	IDA	12620231 19228685
GO:0042903	tubulin deacetylase activity	-	IMP	19457097
GO:0042903	tubulin deacetylase activity	-	ISS	-
GO:0042903	tubulin deacetylase activity	-	TAS	19457097
GO:0043014	alpha-tubulin binding	-	IDA	19228685
GO:0043130	ubiquitin binding	-	IEA	-
GO:0048156	tau protein binding	-	IDA	18636984
GO:0048156	tau protein binding	-	ISS	19457097
GO:0048156	tau protein binding	-	TAS	19457097
GO:0048487	beta-tubulin binding	-	IEA	-
GO:0051787	misfolded protein binding	-	EXP	17785525
GO:0051879	Hsp90 protein binding	-	IDA	15916966
GO:0070840	dynein complex binding	-	IDA	14675537

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000209	protein polyubiquitination	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006476	protein deacetylation	-	IMP	15916966
GO:0006476	protein deacetylation	-	TAS	28386764
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	-	IMP	14675537
GO:0006886	intracellular protein transport	-	IMP	16192271
GO:0006914	autophagy	-	IEA	-
GO:0007026	negative regulation of microtubule depolymerization	-	IEA	-
GO:0009636	response to toxic substance	-	IMP	19158084
GO:0009967	positive regulation of signal transduction	-	IMP	19158084
GO:0010033	response to organic substance	-	IMP	19158084
GO:0010469	regulation of signaling receptor activity	-	IMP	19158084
GO:0010506	regulation of autophagy	-	TAS	25548531
GO:0010634	positive regulation of epithelial cell migration	-	IMP	12024216
GO:0010727	negative regulation of hydrogen peroxide metabolic process	-	IC	18606987
GO:0010870	positive regulation of receptor biosynthetic process	-	IMP	15916966 18316616
GO:0016241	regulation of macroautophagy	-	IMP	16192271
GO:0016575	histone deacetylation	-	IDA	10220385
GO:0016575	histone deacetylation	-	ISS	11861901
GO:0031647	regulation of protein stability	-	IMP	23580651
GO:0032418	lysosome localization	-	IMP	16192271
GO:0032461	positive regulation of protein oligomerization	-	IMP	23962722
GO:0032984	protein-containing complex disassembly	-	IEA	-
GO:0033138	positive regulation of peptidyl-serine phosphorylation	-	IMP	23962722
GO:0034983	peptidyl-lysine deacetylation	-	IMP	18356165 18606987 23962722
GO:0035967	cellular response to topologically incorrect protein	-	IMP	16192271
GO:0040029	regulation of gene expression, epigenetic	-	IMP	24413532
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	-	IEA	-
GO:0043242	negative regulation of protein complex disassembly	-	IMP	15916966
GO:0045598	regulation of fat cell differentiation	-	IEA	-
GO:0045861	negative regulation of proteolysis	-	IMP	18356165
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	11861901
GO:0048668	collateral sprouting	-	IEA	-
GO:0051354	negative regulation of oxidoreductase activity	-	IC	18606987
GO:0051646	mitochondrion localization	-	IEA	-
GO:0051788	response to misfolded protein	-	IMP	14675537
GO:0060271	cilium assembly	-	TAS	-
GO:0060632	regulation of microtubule-based movement	-	IC	19228685
GO:0060765	regulation of androgen receptor signaling pathway	-	TAS	18852123
GO:0060997	dendritic spine morphogenesis	-	IEA	-
GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	-	IGI	20457763
GO:0070201	regulation of establishment of protein localization	-	IEA	-
GO:0070301	cellular response to hydrogen peroxide	-	IMP	18606987
GO:0070842	aggresome assembly	-	IMP	14675537
GO:0070845	polyubiquitinated misfolded protein transport	-	IMP	14675537
GO:0070846	Hsp90 deacetylation	-	IMP	19158084
GO:0070848	response to growth factor	-	IMP	18356165
GO:0070932	histone H3 deacetylation	-	IEA	-
GO:0071218	cellular response to misfolded protein	-	IEA	-
GO:0090035	positive regulation of chaperone-mediated protein complex assembly	-	IMP	19158084
GO:0090042	tubulin deacetylation	-	IDA	19228685
GO:0090042	tubulin deacetylation	-	ISS	-
GO:0090042	tubulin deacetylation	-	TAS	28386764
GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	-	IDA	18606987
GO:1903146	regulation of autophagy of mitochondrion	-	TAS	25548531

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000118	histone deacetylase complex	-	IDA	11948178
GO:0005634	nucleus	-	ISS	-
GO:0005654	nucleoplasm	-	IDA	-
GO:0005737	cytoplasm	-	IDA	24687993
GO:0005737	cytoplasm	-	ISS	11861901
GO:0005737	cytoplasm	-	TAS	19457097
GO:0005771	multivesicular body	-	TAS	25548531
GO:0005829	cytosol	-	ISS	-
GO:0005829	cytosol	-	TAS	-
GO:0005874	microtubule	-	IDA	12620231
GO:0005875	microtubule associated complex	-	IDA	19228685
GO:0005881	cytoplasmic microtubule	-	IEA	-
GO:0005901	caveola	-	IDA	18356165
GO:0016234	inclusion body	-	IDA	16192271
GO:0016235	aggresome	-	IDA	14675537
GO:0016235	aggresome	-	TAS	19457097
GO:0030286	dynein complex	colocalizes_with	IDA	14675537
GO:0030424	axon	-	ISS	-
GO:0030425	dendrite	-	ISS	-
GO:0031252	cell leading edge	-	IDA	12024216
GO:0043204	perikaryon	-	ISS	-
GO:0048471	perinuclear region of cytoplasm	-	IDA	12024216

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-157118	Signaling by NOTCH	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-1980143	Signaling by NOTCH1	IEA
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	TAS
R-HSA-2644603	Signaling by NOTCH1 in Cancer	TAS
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	TAS
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	TAS
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	TAS
R-HSA-3371511	HSF1 activation	TAS
R-HSA-3371556	Cellular response to heat stress	TAS
R-HSA-5617833	Cilium Assembly	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-8878166	Transcriptional regulation by RUNX2	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	IEA
R-HSA-8941326	RUNX2 regulates bone development	IEA
R-HSA-8953897	Cellular responses to external stimuli	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22490492	Nicotine inhibits histone deacetylase 6 activity and chaperone-dependent activation of the glucocorticoid receptor in A549 cells. (2012 Feb)	Sun LC	Chin Med J (Engl)