Gene info: ID 10016

Gene: PDCD6

GENE ID: 10016

Synonyms: ALG-2|ALG2|PEF1B

Description: programmed cell death 6

Gene type: protein-coding

Location: 5p15.33

dbXrefs: Ensembl:ENSG00000249915 MIM:601057 Vega:OTTHUMG00000090283 UniprotKB:O75340

RefSeq: NC_000005.10

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.029e-1 (AD) 5.579e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs9654453	chr5:299506 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EMC4	0.959
MANBAL	0.958
PSMB7	0.955
CLTA	0.948
EIF6	0.945
PSMD13	0.944
BRK1	0.944
APEX1	0.943
NDUFC2	0.943
MRPS23	0.943

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.786
OR4F29	-0.738
MTRNR2L6	-0.358
MTRNR2L9	-0.356
MTRNR2L10	-0.31
MTRNR2L3	-0.257
C8orf74	-0.257
PPBP	-0.255
TTLL10	-0.255
MAGEA12	-0.254

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01373	Calcium	Small Molecule	7440-70-2	Approved\|Nutraceutical	Target
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB11093	Calcium Citrate	Small Molecule	813-94-5	Approved	Target
DB11348	Calcium Phosphate	Small Molecule	10103-46-5	Approved	Target

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of PDCD6 mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDCD6 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDCD6 mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PDCD6 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of PDCD6 gene	27153756
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDCD6 mRNA"	20018196
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PDCD6 mRNA"	20382639
D004958	Estradiol	Estradiol results in increased expression of PDCD6 mRNA	22467019
C006780	bisphenol A	bisphenol A affects the expression of PDCD6 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of PDCD6 protein	28641223
C006780	bisphenol A	bisphenol A affects the expression of PDCD6 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of PDCD6 mRNA	25181051
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDCD6 mRNA	17602206
D003042	Cocaine	Cocaine affects the expression of PDCD6 mRNA	15681117
D016572	Cyclosporine	Cyclosporine results in decreased methylation of PDCD6 promoter	27989131
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PDCD6 mRNA]	27941970
D064730	Dexrazoxane	[Doxorubicin co-treated with Dexrazoxane] results in increased expression of PDCD6 mRNA	26873546
D003976	Diazinon	Diazinon affects the expression of PDCD6 mRNA	22546817
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in decreased expression of PDCD6 mRNA"	25908611
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PDCD6 mRNA	17361019
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PDCD6 mRNA	21266533
D004026	Dieldrin	Dieldrin affects the expression of PDCD6 mRNA	22546817
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of PDCD6 mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of PDCD6 mRNA]	19850644
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDCD6 mRNA	17602206
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of PDCD6 mRNA	15766595
D004237	Diuron	Diuron results in increased expression of PDCD6 mRNA	21551480
D004317	Doxorubicin	[Doxorubicin co-treated with Dexrazoxane] results in increased expression of PDCD6 mRNA	26873546
D004317	Doxorubicin	Doxorubicin results in decreased expression of PDCD6 mRNA	26873546
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PDCD6 mRNA	17555576
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDCD6 mRNA	17942748
D005485	Flutamide	Flutamide results in increased expression of PDCD6 mRNA	24136188
D005839	Gentamicins	Gentamicins results in increased expression of PDCD6 mRNA	22061828
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PDCD6 mRNA	25613284
C045463	leflunomide	leflunomide results in increased expression of PDCD6 mRNA	24136188
D008094	Lithium	Lithium results in increased expression of PDCD6 protein	18296634
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of PDCD6 mRNA	26378955
C063855	microcystin RR	microcystin RR results in decreased expression of PDCD6 protein	19111056
D009151	Mustard Gas	Mustard Gas results in increased expression of PDCD6 mRNA	15674843
C022838	nickel chloride	nickel chloride affects the expression of PDCD6 mRNA	22546817
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of PDCD6 mRNA	23948077
D012906	Smoke	Smoke results in decreased expression of PDCD6 mRNA	21095227
C017947	sodium arsenite	sodium arsenite results in decreased expression of PDCD6 mRNA	12760830
C017947	sodium arsenite	sodium arsenite results in increased expression of and affects the splicing of PDCD6 mRNA	25879800
C017947	sodium arsenite	sodium arsenite results in increased expression of PDCD6 mRNA	28595984
D010042	Ouabain	Ouabain results in increased expression of PDCD6 protein	18247327
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of PDCD6 mRNA	26378955
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDCD6 mRNA	17942748
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PDCD6 mRNA	25613284
C012589	trichostatin A	trichostatin A results in increased expression of PDCD6 mRNA	15901671
D014635	Valproic Acid	Valproic Acid results in increased expression of PDCD6 mRNA	15901671
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDCD6 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of PDCD6 mRNA	23179753\|2438349
C034028	vanadyl sulfate	vanadyl sulfate results in increased expression of PDCD6 mRNA	16330358
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of PDCD6 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	ISS	-
GO:0005509	calcium ion binding	-	IDA	25667979
GO:0005509	calcium ion binding	-	ISS	-
GO:0005515	protein binding	-	IPI	11883939 16132846 16189514 17174262 17196169 18256029 18940611 21893193 21988832 23924735 25416956 25667979 25910212 26950892 27716508 27784779 27813252
GO:0042802	identical protein binding	-	IPI	16189514 18940611 21988832 25416956
GO:0042803	protein homodimerization activity	-	IDA	25667979
GO:0043495	protein membrane anchor	-	IMP	16957052
GO:0046983	protein dimerization activity	-	IPI	11883899
GO:0048306	calcium-dependent protein binding	-	IPI	16957052 17196169 17214967 18256029 23924735 27716508
GO:0060090	molecular adaptor activity	-	IMP	19520058 27716508

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001525	angiogenesis	-	IEA	-
GO:0001938	positive regulation of endothelial cell proliferation	-	IDA	21893193
GO:0006508	proteolysis	-	IEA	-
GO:0006886	intracellular protein transport	-	IDA	21122810
GO:0006888	ER to Golgi vesicle-mediated transport	-	IMP	27716508 27813252
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	IEA	-
GO:0010595	positive regulation of endothelial cell migration	-	IDA	21893193
GO:0014029	neural crest formation	-	IMP	27716508
GO:0014032	neural crest cell development	-	IMP	27716508
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	-	IDA	21893193
GO:0032007	negative regulation of TOR signaling	-	IDA	21893193
GO:0034605	cellular response to heat	-	IDA	21122810
GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway	-	IDA	21893193
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	16132846
GO:0045766	positive regulation of angiogenesis	-	IDA	21893193
GO:0048208	COPII vesicle coating	-	IMP	27716508
GO:0051592	response to calcium ion	-	ISS	-
GO:0051898	negative regulation of protein kinase B signaling	-	IDA	21893193
GO:0097190	apoptotic signaling pathway	-	TAS	8560270
GO:1902527	positive regulation of protein monoubiquitination	-	IMP	27716508

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	IEA	-
GO:0005634	nucleus	-	IDA	16957052 17196169 21122810 27784779
GO:0005737	cytoplasm	-	IDA	21122810 27784779
GO:0005768	endosome	-	IEA	-
GO:0005783	endoplasmic reticulum	-	IDA	17196169
GO:0005789	endoplasmic reticulum membrane	-	IEA	-
GO:0030127	COPII vesicle coat	-	IDA	27716508
GO:0031410	cytoplasmic vesicle	-	IDA	21122810
GO:0031463	Cul3-RING ubiquitin ligase complex	colocalizes_with	IDA	27716508
GO:0070062	extracellular exosome	-	HDA	19056867 20458337 23533145
GO:0070971	endoplasmic reticulum exit site	-	IDA	27813252
GO:0070971	endoplasmic reticulum exit site	-	IMP	16957052

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal