Gene: SH2B3

10019
IDDM20|LNK
SH2B adaptor protein 3
protein-coding
12q24.12
Ensembl:ENSG00000111252 MIM:605093 Vega:OTTHUMG00000169550 UniprotKB:Q9UQQ2
NG_021216.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.455e-2 (AD)  7.950e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EHBP1L10.833
CYFIP10.809
ST6GAL10.787
FHOD10.783
MYH90.782
STK100.777
CTTNBP2NL0.777
LRCH10.776
VCL0.762
COLGALT10.761

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.428
OR4F29-0.405
PDE11A-0.26
HCRT-0.252
C5orf38-0.252
PMCH-0.248
NKX2-8-0.247
TH-0.246
SOX3-0.238
NCBP2L-0.233

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06589PazopanibSmall Molecule444731-52-6ApprovedTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SH2B3 mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SH2B3 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SH2B3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SH2B3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SH2B3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SH2B3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SH2B3 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SH2B3 mRNA27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SH2B3 mRNA24449571
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of SH2B3 mRNA18585445
C006632arsenic trioxidearsenic trioxide results in decreased expression of SH2B3 mRNA25258189
C015001arsenitearsenite results in increased methylation of SH2B3 promoter23974009
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of SH2B3 mRNA18585445
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SH2B3 mRNA20106945
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SH2B3 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of SH2B3 mRNA23019147
C044887beta-methylcholinebeta-methylcholine affects the expression of SH2B3 mRNA21179406
C006780bisphenol Abisphenol A results in decreased methylation of SH2B3 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of SH2B3 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SH2B3 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SH2B3 mRNA15336504
C584509C646 compoundC646 compound results in decreased expression of SH2B3 mRNA26191083
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SH2B3 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of SH2B3 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of SH2B3 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of SH2B3 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of SH2B3 mRNA20106945|2163298
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SH2B3 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of SH2B3 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SH2B3 mRNA21266533
D002945CisplatinCisplatin results in increased expression of SH2B3 mRNA27392435|2759478
D002945CisplatinSH2B3 protein affects the susceptibility to Cisplatin16217747
D002945CisplatinCisplatin results in increased phosphorylation of SH2B3 protein22006019
C000944dicrotophosdicrotophos results in increased expression of SH2B3 mRNA28302478
C118739entinostatentinostat results in increased expression of SH2B3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SH2B3 mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SH2B3 gene20938992
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SH2B3 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of SH2B3 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SH2B3 mRNA28628672
C045463leflunomideleflunomide results in increased expression of SH2B3 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SH2B3 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SH2B3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SH2B3 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SH2B3 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SH2B3 mRNA"25620056
D009532NickelNickel results in increased expression of SH2B3 mRNA25583101
C030110oxaliplatinoxaliplatin results in decreased expression of SH2B3 mRNA17762391
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SH2B3 mRNA19710929
D010894PiroxicamPiroxicam results in increased expression of SH2B3 mRNA21858171
D011794QuercetinQuercetin results in increased expression of SH2B3 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SH2B3 mRNA25895662
D012834SilverSilver results in increased expression of SH2B3 mRNA26014281
D053260SootSoot results in increased expression of SH2B3 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SH2B3 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SH2B3 mRNA24680724
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of SH2B3 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of SH2B3 mRNA23557971
D014212TretinoinTretinoin results in increased expression of SH2B3 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SH2B3 mRNA"26179874
D014520UrethaneUrethane results in increased expression of SH2B3 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SH2B3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SH2B3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SH2B3 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of SH2B3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of SH2B3 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005068transmembrane receptor protein tyrosine kinase adaptor activity-IBA21873635  
GO:0005515protein binding-IPI16273093  24728074  
GO:0035591signaling adaptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007596blood coagulation-TAS-  
GO:0009967positive regulation of signal transduction-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0035162embryonic hemopoiesis-IEA-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0035556intracellular signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
KEGG ID KEGG Term
hsa04722Neurotrophin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1433557Signaling by SCF-KITTAS
R-HSA-1433559Regulation of KIT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25345847The association of thyroid peroxidase antibody risk loci with susceptibility to and phenotype of Graves' disease. (2015 Oct)Kus AClin Endocrinol (Oxf)
25009551The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study. (2014)Kullo IJFront Genet
22216278Large scale association analysis identifies three susceptibility loci for coronary artery disease. (2011)Saade SPLoS One
29030599Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. (2017 Oct 13)Joshi PKNat Commun