Gene: CDH4

1002
CAD4|R-CAD|RCAD
cadherin 4
protein-coding
20q13.33
Ensembl:ENSG00000179242 MIM:603006 Vega:OTTHUMG00000032890 UniprotKB:P55283
NC_000020.11
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.073e-1 (AD)  7.455e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6089556chr20:61929031 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TBC1D160.847
BCR0.84
GABBR10.837
PRRC2A0.831
TOM1L20.829
ABAT0.827
DTX10.827
SGSM20.823
ARHGEF40.823
CPNE60.822

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.607
OR4F29-0.558
SGMS2-0.399
CD48-0.391
CLEC2B-0.385
SFN-0.384
TFPI2-0.373
CLEC6A-0.366
VRK2-0.363
BCL2A1-0.363

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CDH4 mRNA"25614096
D000082AcetaminophenAcetaminophen results in decreased expression of CDH4 mRNA22230336|2669055
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDH4 mRNA16483693
D001151ArsenicArsenic affects the methylation of CDH4 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene affects the reaction [AHR protein binds to CDH4 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDH4 mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDH4 mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of CDH4 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CDH4 mRNA22079614
C018475butyraldehydebutyraldehyde results in decreased expression of CDH4 mRNA26079696
D002101Cacodylic AcidCacodylic Acid results in increased expression of CDH4 mRNA17441966
D002101Cacodylic AcidOGG1 protein inhibits the reaction [Cacodylic Acid results in increased expression of CDH4 mRNA]17441966
D007631ChlordeconeCDH4 gene SNP affects the susceptibility to Chlordecone25622337
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDH4 gene20938992
D002994ClofibrateClofibrate results in increased expression of CDH4 mRNA17585979
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of CDH4 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of CDH4 mRNA27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of CDH4 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of CDH4 mRNA25270620
D004041Dietary FatsDietary Fats results in increased expression of CDH4 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CDH4 mRNA20360939
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDH4 gene20938992
C001277geldanamycingeldanamycin results in increased expression of CDH4 mRNA26705709
C051890irinotecanirinotecan analog results in decreased expression of CDH4 mRNA18927307
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of CDH4 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of CDH4 mRNA]27392435
C018091maduramicinmaduramicin results in increased expression of CDH4 mRNA29128925
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDH4 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of CDH4 mRNA17379860
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CDH4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CDH4 mRNA"25554681
D000073878Palm OilPalm Oil results in increased expression of CDH4 mRNA18042831
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CDH4 mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of CDH4 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of CDH4 mRNA24780913
C043680ptaquilosideptaquiloside results in decreased expression of CDH4 mRNA23274088
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CDH4 mRNA23806026
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CDH4 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of CDH4 gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDH4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the reaction [AHR protein binds to CDH4 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of CDH4 gene21212295
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CDH4 mRNA27404394
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of CDH4 mRNA]27469509
C012589trichostatin Atrichostatin A results in decreased expression of CDH4 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of CDH4 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CDH4 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of CDH4 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CDH4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of CDH4 gene29154799
D014638VanadatesVanadates results in increased expression of CDH4 mRNA22714537
D019287Zinc SulfateZinc Sulfate results in increased expression of CDH4 mRNA27504894
C088658zoledronic acidzoledronic acid results in increased expression of CDH4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IEA-  
GO:0008092cytoskeletal protein binding-IBA21873635  
GO:0042803protein homodimerization activity-IBA21873635  
GO:0045296cadherin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IBA21873635  
GO:0007043cell-cell junction assembly-IBA21873635  
GO:0007155cell adhesion-TAS2059658  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0007411axon guidance-IEA-  
GO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-IBA21873635  
GO:0031175neuron projection development-IBA21873635  
GO:0034332adherens junction organization-IBA21873635  
GO:0034332adherens junction organization-TAS-  
GO:0044331cell-cell adhesion mediated by cadherin-IBA21873635  
GO:0045773positive regulation of axon extension-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0009986cell surface-IBA21873635  
GO:0016342catenin complex-IBA21873635  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-375170CDO in myogenesisTAS
R-HSA-375170CDO in myogenesisIEA
R-HSA-418990Adherens junctions interactionsTAS
R-HSA-421270Cell-cell junction organizationTAS
R-HSA-446728Cell junction organizationTAS
R-HSA-525793MyogenesisTAS
R-HSA-525793MyogenesisIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28095912Study on expression of CDH4 in lung cancer. (2017 Jan 17)Li ZWorld J Surg Oncol