Gene: GNE

10020
DMRV|GLCNE|IBM2|NM|Uae1
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
protein-coding
9p13.3
Ensembl:ENSG00000159921 MIM:603824 Vega:OTTHUMG00000019899 UniprotKB:Q9Y223
NG_008246.1
PubMed
0   ANCO-SNPs
CD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.612e-1 (AD)  2.774e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HECTD10.945
RALGAPB0.945
TRAPPC80.934
KPNA60.934
AP1G10.931
GAPVD10.93
ANKRD170.927
KRIT10.927
RNF1110.926
PHF200.926

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.542
OR4F29-0.498
MTRNR2L6-0.309
S100A14-0.307
CSAG1-0.295
MTRNR2L10-0.291
S100A1-0.285
HES1-0.28
ASB4-0.279
MTRNR2L9-0.278

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of GNE mRNA"19162173
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of GNE mRNA"22101062
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GNE mRNA"19114083
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of GNE mRNA]"19467301
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of GNE mRNA"21218783
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNE mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNE mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of GNE mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of GNE mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GNE mRNA]17585979
D019158N-Acetylneuraminic AcidGNE protein results in increased chemical synthesis of N-Acetylneuraminic Acid9305888
D020106AcrylamideAcrylamide results in increased expression of GNE mRNA28959563
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of GNE protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of GNE protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GNE mRNA16483693
D001151ArsenicArsenic affects the methylation of GNE gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of GNE mRNA27829220
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GNE mRNA19770486|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GNE mRNA"20382639
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of GNE mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of GNE mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of GNE mRNA28159858
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of GNE mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of GNE mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of GNE mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of GNE promoter22457795
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of GNE mRNA18178546
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GNE mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of GNE mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of GNE mRNA17585979|2381119
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GNE mRNA]17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GNE mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of GNE mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of GNE mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of GNE mRNA27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GNE mRNA17361019|2126653
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of GNE mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of GNE mRNA15238619
D004041Dietary FatsDietary Fats results in increased expression of GNE mRNA19467301
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GNE mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of GNE mRNA28943392
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GNE mRNA22079256
C082360fipronilfipronil results in decreased expression of GNE mRNA23962444
D005419FlavonoidsFlavonoids results in decreased expression of GNE mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of GNE protein15352031
D005472FluorouracilGNE protein affects the susceptibility to Fluorouracil15352031
D005485FlutamideFlutamide results in decreased expression of GNE mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GNE mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of GNE mRNA23649840
D005978GlutathioneGlutathione deficiency results in decreased expression of GNE mRNA20621112
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of GNE mRNA20044591
C045463leflunomideleflunomide results in decreased expression of GNE mRNA24136188
C042720mercuric bromidemercuric bromide results in decreased expression of GNE mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNE mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GNE mRNA20938992
D008727MethotrexateGNE protein affects the susceptibility to Methotrexate16217747
D008727MethotrexateMethotrexate affects the expression of GNE mRNA18502557
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of GNE mRNA"29244179
C051752nefazodonenefazodone results in decreased expression of GNE mRNA24136188
C012655nimesulidenimesulide results in decreased expression of GNE mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of GNE mRNA17616710
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of GNE mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of GNE mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of GNE mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of GNE mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of GNE mRNA]17655762
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of GNE mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of GNE mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of GNE mRNA]17655762
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of GNE mRNA19162173
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of GNE mRNA17097637
D010634PhenobarbitalPhenobarbital results in increased expression of GNE mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNE mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GNE mRNA26272509
C006253pirinixic acidNCF1 protein inhibits the reaction [pirinixic acid results in decreased expression of GNE mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of GNE mRNA17426115|1795077
C006253pirinixic acidpirinixic acid results in decreased expression of GNE mRNA19162173
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GNE mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GNE mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of GNE mRNA19162173
C015586propiverinepropiverine binds to GNE protein29273565
D053260SootSoot results in increased expression of GNE mRNA22461453
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GNE mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GNE mRNA19465110|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GNE mRNA16054898|2095900
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of GNE mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of GNE mRNA23411599
D013893ThiramThiram results in increased expression of GNE mRNA20530235
D014212TretinoinTretinoin results in increased expression of GNE mRNA23830798
D014241TrichloroethyleneTrichloroethylene results in decreased expression of GNE mRNA19448997
C057693troglitazonetroglitazone results in decreased expression of GNE mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of GNE mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GNE mRNA23179753|2519280
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of GNE mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of GNE mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of GNE mRNA]17655762

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0005524ATP binding-IEA-  
GO:0008761UDP-N-acetylglucosamine 2-epimerase activity-TAS-  
GO:0009384N-acylmannosamine kinase activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006045N-acetylglucosamine biosynthetic process-IEA-  
GO:0006047UDP-N-acetylglucosamine metabolic process-IEA-  
GO:0006054N-acetylneuraminate metabolic process-TAS9305888  
GO:0007155cell adhesion-TAS10334995  
GO:0046835carbohydrate phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS9305888  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4085001Sialic acid metabolismTAS
R-HSA-4085011Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2TAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-5609975Diseases associated with glycosylation precursor biosynthesisTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23627877Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design. (2013 May 9)Cai XJ Med Chem
29317163Investigations into the efficacy of multi-component cocaine vaccines. (2017 Dec 20)Kimishima ABioorg Med Chem Lett
29795751Efficient Syntheses of Cocaine Vaccines and Their in Vivo Evaluation. (2018 May 10)Kimishima AACS Med Chem Lett
25531528Flagellin as carrier and adjuvant in cocaine vaccine development. (2015 Feb 2)Lockner JWMol Pharm