Gene: TROAP

10024
TASTIN
trophinin associated protein
protein-coding
12q13.12
Ensembl:ENSG00000135451 MIM:603872 Vega:OTTHUMG00000169486 UniprotKB:Q12815
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.593e-1 (AD)  1.270e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4898519chr12:49320320 (GRCh38.p7)A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MKI670.877
TOP2A0.82
CEP550.789
KIF20A0.772
RRM20.761
AURKB0.725
BIRC50.67
DLGAP50.649
HJURP0.646
MYBL20.632

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.311
MESP2-0.304
WFDC1-0.302
CALML3-0.288
ACY3-0.283
ZSCAN1-0.278
CPLX3-0.278
HES5-0.274
CSDC2-0.267
ARSF-0.266

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TROAP mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TROAP mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TROAP mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TROAP mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TROAP mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TROAP mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TROAP mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TROAP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TROAP mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TROAP mRNA22230336
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TROAP mRNA22129741
D020106AcrylamideAcrylamide results in increased expression of TROAP mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TROAP mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TROAP mRNA24449571
D001151ArsenicArsenic affects the methylation of TROAP gene25304211
C547126AZM551248AZM551248 results in increased expression of TROAP mRNA22323515
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TROAP mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of TROAP mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of TROAP mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TROAP mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of TROAP mRNA26079696
D007631ChlordeconeTROAP gene SNP affects the susceptibility to Chlordecone25622337
C018021cobaltous chloridecobaltous chloride results in decreased expression of TROAP mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of TROAP mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of TROAP mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of TROAP mRNA19167446
D003471CuprizoneCuprizone affects the expression of TROAP mRNA26577399
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TROAP mRNA28628672
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TROAP mRNA22129741
D002117CalcitriolCalcitriol results in decreased expression of TROAP mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of TROAP mRNA21592394
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TROAP protein23301498
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of TROAP mRNA]15016801
C039281furanfuran results in increased expression of TROAP mRNA25539665
C492448ICG 001ICG 001 results in decreased expression of TROAP mRNA26191083
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TROAP mRNA22129741
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TROAP mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of TROAP mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TROAP mRNA28628672
C544151jinfukangjinfukang results in increased expression of TROAP mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TROAP mRNA24796395
C045463leflunomideleflunomide results in decreased expression of TROAP mRNA28988120
C045463leflunomideleflunomide results in decreased expression of TROAP mRNA24136188
D008748MethylcholanthreneMethylcholanthrene results in increased expression of TROAP mRNA20713471
D015735MifepristoneMifepristone results in increased expression of TROAP mRNA19439560
D009151Mustard GasMustard Gas results in decreased expression of TROAP mRNA25102026
C028007nickel monoxidenickel monoxide results in decreased expression of TROAP mRNA19167457
C570897NSC668394NSC668394 results in decreased expression of TROAP mRNA27137931
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TROAP mRNA25729387
D010126OzoneOzone results in decreased expression of TROAP mRNA24336422
C500026palbociclibpalbociclib results in decreased expression of TROAP mRNA22869556
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TROAP mRNA"25510870
D011374ProgesteroneProgesterone results in decreased expression of TROAP mRNA23012394
C005556propionaldehydepropionaldehyde results in decreased expression of TROAP mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of TROAP mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of TROAP mRNA19167446
C061133tamibarotenetamibarotene results in decreased expression of TROAP mRNA15498508
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of TROAP mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of TROAP mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TROAP mRNA26377647
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of TROAP mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of TROAP mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TROAP mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TROAP mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TROAP mRNA25729387
D014212TretinoinTretinoin results in decreased expression of TROAP mRNA15498508|2372400
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TROAP mRNA19042947
D014520UrethaneUrethane results in increased expression of TROAP mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TROAP mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of TROAP mRNA23179753|2627250
D014639VanadiumVanadium results in increased expression of TROAP mRNA19000753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9560222  17360433  19060904  21516116  23602568  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal