Gene: PARP3

10039
ADPRT3|ADPRTL2|ADPRTL3|ARTD3|IRT1|PADPRT-3
poly(ADP-ribose) polymerase family member 3
protein-coding
3p21.2
Ensembl:ENSG00000041880 MIM:607726 Vega:OTTHUMG00000156931 UniprotKB:Q9Y6F1
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.404e-1 (AD)  7.350e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MED290.84
TMEM1290.833
SNX210.825
GORASP10.823
IVD0.823
PYCR20.822
BCKDHA0.821
TAB10.82
ORMDL30.819
DCTD0.819

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.695
OR4F29-0.657
MTRNR2L6-0.345
SPRR4-0.338
MTRNR2L9-0.336
GSDMA-0.323
SLC18A1-0.309
KCNJ15-0.303
SULT1E1-0.301
GADL1-0.297

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB076772-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-oneSmall MoleculeExperimentalTarget
DB080584-[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-oneSmall MoleculeExperimentalTarget
DB08348N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDESmall MoleculeExperimentalTarget
DB09074OlaparibSmall Molecule763113-22-0ApprovedTarget
DB12332RucaparibSmall Molecule283173-50-2Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PARP3 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of PARP3 mRNA17562736
D004958EstradiolEstradiol affects the expression of PARP3 mRNA22574217
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PARP3 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of PARP3 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PARP3 mRNA27339419
D002737ChloropreneChloroprene results in decreased expression of PARP3 mRNA23125180
D003471CuprizoneCuprizone results in increased expression of PARP3 mRNA26577399
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PARP3 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PARP3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of PARP3 mRNA27392435|2759478
D004041Dietary FatsDietary Fats results in decreased expression of PARP3 mRNA18042831|2501614
D004147DioxinsDioxins affects the expression of PARP3 mRNA20463971
C540355fenamidonefenamidone results in increased expression of PARP3 mRNA27029645
D005485FlutamideFlutamide results in decreased expression of PARP3 mRNA21126777
D005485FlutamideFlutamide results in decreased expression of PARP3 mRNA24793618
D017313FenretinideFenretinide results in decreased expression of PARP3 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of PARP3 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PARP3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PARP3 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PARP3 mRNA27392435
C544151jinfukangjinfukang results in increased expression of PARP3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PARP3 mRNA23086925|2479639
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PARP3 mRNA21641980
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PARP3 mRNA26011545
D008774MethylphenidateMethylphenidate results in increased expression of PARP3 mRNA22470460
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PARP3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PARP3 mRNA"25554681
D000073878Palm OilPalm Oil results in decreased expression of PARP3 mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of PARP3 mRNA23892564
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PARP3 mRNA19710929
D011441PropylthiouracilPropylthiouracil results in decreased expression of PARP3 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PARP3 mRNA27029645
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PARP3 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PARP3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PARP3 mRNA22298810
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of PARP3 mRNA28973375
C009495titanium dioxidetitanium dioxide results in increased expression of PARP3 mRNA27760801
D014635Valproic AcidValproic Acid results in decreased expression of PARP3 mRNA29154799
D014638VanadatesVanadates results in increased expression of PARP3 mRNA22714537
D014640VancomycinVancomycin results in decreased expression of PARP3 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PARP3 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PARP3 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-TAS10338144  
GO:0003950NAD+ ADP-ribosyltransferase activity-IBA21873635  
GO:0003950NAD+ ADP-ribosyltransferase activity-IDA21211721  21270334  
GO ID GO Term Qualifier Evidence PubMed
GO:0000723telomere maintenance-IMP21270334  
GO:0006281DNA repair-TAS7260241  
GO:0006302double-strand break repair-IBA21873635  
GO:0006302double-strand break repair-IDA21270334  
GO:0006302double-strand break repair-IMP21211721  
GO:0006471protein ADP-ribosylation-IBA21873635  
GO:0006471protein ADP-ribosylation-IDA21270334  
GO:0051106positive regulation of DNA ligation-IGI21211721  
GO:0060236regulation of mitotic spindle organization-IMP21270334  
GO:1905662negative regulation of telomerase RNA reverse transcriptase activity-IMP24528514  
GO:1990166protein localization to site of double-strand break-IMP21211721  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
GO:0005814centriole-IEA-  
GO:0035861site of double-strand break-IBA21873635  
GO:0035861site of double-strand break-IDA21270334  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17203305Genetic variation in the base excision repair pathway and bladder cancer risk. (2007 Apr)Figueroa JDHum Genet