Gene: HMGXB4

10042
HMG2L1|HMGBCG|THC211630
HMG-box containing 4
protein-coding
22q12.3
Ensembl:ENSG00000100281 MIM:604702 Vega:OTTHUMG00000150439 UniprotKB:Q9UGU5
NC_000022.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.656e-2 (AD)  3.957e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2092029chr22:35256248 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM208A0.88
BBIP10.878
SLC11A20.875
ZKSCAN10.875
ARID4B0.87
UBA60.869
INTS20.869
UBXN40.869
ITCH0.869
IBTK0.867

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.525
OR4F29-0.525
G0S2-0.281
PLA2G5-0.256
MTRNR2L6-0.249
FOXJ1-0.236
MTRNR2L9-0.233
MOGAT2-0.227
HSPA6-0.224
OR4F16-0.223

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of HMGXB4 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of HMGXB4 mRNA28959563
D000638AmiodaroneAmiodarone results in increased expression of HMGXB4 mRNA19774075
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HMGXB4 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HMGXB4 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HMGXB4 mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of HMGXB4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HMGXB4 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HMGXB4 mRNA26472689
D016572CyclosporineCyclosporine results in increased expression of HMGXB4 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of HMGXB4 mRNA23640034
D004237DiuronDiuron results in decreased expression of HMGXB4 mRNA25152437
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMGXB4 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in increased expression of HMGXB4 mRNA28189721
D005557FormaldehydeFormaldehyde results in decreased expression of HMGXB4 mRNA20655997
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of HMGXB4 mRNA17183730
C045463leflunomideleflunomide results in increased expression of HMGXB4 mRNA28988120
D010634PhenobarbitalPhenobarbital affects the expression of HMGXB4 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HMGXB4 mRNA19710929
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of HMGXB4 mRNA21427059
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of HMGXB4 mRNA19244175
D012643SeleniumSelenium results in decreased expression of HMGXB4 mRNA19244175
D012999SomanSoman results in decreased expression of HMGXB4 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HMGXB4 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMGXB4 mRNA17942748
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of HMGXB4 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of HMGXB4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HMGXB4 mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in decreased methylation of HMGXB4 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of HMGXB4 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HMGXB4 gene25560391
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of HMGXB4 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of HMGXB4 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008333endosome to lysosome transport-NAS10329004  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030178negative regulation of Wnt signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016589NURF complex-IDA20850016  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal