Gene: CDH7

1005
CDH7L1
cadherin 7
protein-coding
18q22.1
Ensembl:ENSG00000081138 MIM:605806 Vega:OTTHUMG00000132800 UniprotKB:Q9ULB5
NC_000018.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.123e-1 (AD)  1.928e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPM1E0.915
PCDHAC20.898
ARHGAP200.89
SCN8A0.889
DCC0.878
SLC4A80.878
KLHL110.877
GPLD10.876
KCNH10.874
TRPC50.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.646
RAB13-0.626
PXDC1-0.595
AKR1C3-0.582
HVCN1-0.582
AGTRAP-0.58
TMEM176A-0.572
STON2-0.56
TSPO-0.552
GNG5-0.552

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH7 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CDH7 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH7 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH7 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH7 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH7 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CDH7 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH7 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CDH7 gene27153756
C447119bazedoxifenebazedoxifene results in increased expression of CDH7 mRNA19914376
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDH7 mRNA22316170
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of CDH7 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of CDH7 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CDH7 mRNA25181051
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH7 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of CDH7 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDH7 gene20938992
C107676deguelindeguelin results in increased expression of CDH7 mRNA19861542
D003976DiazinonDiazinon results in decreased methylation of CDH7 gene22964155
D000431EthanolEthanol results in decreased expression of CDH7 mRNA28919490
D000431EthanolEthanol results in decreased expression of CDH7 protein28919490
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDH7 gene20938992
D007649KetamineKetamine results in decreased expression of CDH7 mRNA20080153
C008261lead acetatelead acetate results in decreased expression of CDH7 mRNA22641619
C042720mercuric bromidemercuric bromide results in decreased expression of CDH7 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH7 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDH7 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CDH7 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of CDH7 mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of CDH7 mRNA21664453
C008493methylselenic acidmethylselenic acid results in increased expression of CDH7 mRNA12517777
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH7 mRNA"25510870
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDH7 mRNA19710929
D011441PropylthiouracilPropylthiouracil results in decreased expression of CDH7 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of CDH7 mRNA27029645
C017947sodium arsenitesodium arsenite results in increased methylation of CDH7 promoter24118411
D014212TretinoinTretinoin results in increased expression of CDH7 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of CDH7 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH7 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CDH7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of CDH7 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CDH7 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CDH7 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IEA-  
GO:0008092cytoskeletal protein binding-IBA21873635  
GO:0042803protein homodimerization activity-IBA21873635  
GO:0045296cadherin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IBA21873635  
GO:0007043cell-cell junction assembly-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-IBA21873635  
GO:0034332adherens junction organization-IBA21873635  
GO:0034332adherens junction organization-TAS-  
GO:0044331cell-cell adhesion mediated by cadherin-IBA21873635  
GO:0098609cell-cell adhesion-NAS10861224  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0009986cell surface-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0016342catenin complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-418990Adherens junctions interactionsTAS
R-HSA-421270Cell-cell junction organizationTAS
R-HSA-446728Cell junction organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23577725Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis. (2013 May)Naj ACAnn Hum Genet