Gene: MICA

100507436
MIC-A|PERB11.1
MHC class I polypeptide-related sequence A
protein-coding
6p21.33
Ensembl:ENSG00000204520 MIM:600169 Vega:OTTHUMG00000031073 UniprotKB:Q29983
NG_034139.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HDAC70.725
MOV100.724
ECE10.722
LRP100.716
PRICKLE30.715
PLD20.712
PTBP10.706
GLIS20.705
TAP10.702
MSN0.701

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.368
DRD5-0.365
PPEF1-0.352
NMU-0.343
PLD5-0.34
HAPLN1-0.333
AGMAT-0.332
SLC7A4-0.33
SERF1B-0.319
OSTN-0.316

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of MICA mRNA22230336|2906747
D001151ArsenicArsenic affects the methylation of MICA gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of MICA mRNA18463537|2252195
C006632arsenic trioxidearsenic trioxide results in increased expression of MICA protein18463537
C018475butyraldehydebutyraldehyde results in increased expression of MICA mRNA26079696
D002110CaffeineCaffeine inhibits the reaction [resveratrol results in increased expression of MICA protein]23445485
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of MICA mRNA24763279
C018021cobaltous chloridecobaltous chloride results in increased expression of MICA mRNA19376846
D016572CyclosporineCyclosporine results in increased expression of MICA mRNA25562108
C014347decitabinedecitabine affects the expression of MICA mRNA23300844
D002945CisplatinCisplatin affects the expression of MICA mRNA23300844
C118739entinostatentinostat results in increased expression of MICA mRNA27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MICA mRNA23649840
D015025ZearalenoneZearalenone results in increased expression of MICA mRNA27757495
D005472FluorouracilMICA protein affects the susceptibility to Fluorouracil16217747
D005492Folic AcidFolic Acid affects the expression of MICA mRNA16361273
D005557FormaldehydeFormaldehyde results in increased expression of MICA mRNA23649840
C419708gefitinibgefitinib results in increased expression of MICA protein21951556
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of MICA mRNA24763279
C015329lycopenelycopene results in increased expression of MICA mRNA16886892
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MICA mRNA23649840
C523799MRK 003MRK 003 results in decreased expression of MICA mRNA21169257
D009151Mustard GasMustard Gas results in increased phosphorylation of MICA protein19845377
C119536nickel acetateNFE2L2 protein inhibits the reaction [nickel acetate results in increased expression of MICA mRNA]23023193
C119536nickel acetatenickel acetate results in increased expression of MICA mRNA23023193
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MICA mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of MICA mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of MICA mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MICA mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MICA mRNA]17655762
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of MICA mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of MICA mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MICA mRNA]17655762
D010634PhenobarbitalPhenobarbital affects the expression of MICA mRNA19159669
C005556propionaldehydepropionaldehyde results in increased expression of MICA mRNA26079696
C059514resveratrolATM mutant form inhibits the reaction [resveratrol results in increased expression of MICA protein]23445485
C059514resveratrolCaffeine inhibits the reaction [resveratrol results in increased expression of MICA protein]23445485
C059514resveratrolresveratrol results in increased expression of MICA mRNA22406996|2344548
C059514resveratrolresveratrol results in increased expression of MICA protein23445485
C017947sodium arsenitesodium arsenite results in decreased expression of MICA mRNA24516582
D012460SulfasalazineSulfasalazine results in decreased expression of MICA mRNA15494508
D012460SulfasalazineSulfasalazine results in decreased expression of MICA protein15494508
D013849ThimerosalThimerosal results in decreased expression of MICA mRNA27188386
D014635Valproic AcidValproic Acid affects the expression of MICA mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MICA mRNA23179753|2718838
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of MICA mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of MICA mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MICA mRNA]17655762
C111237vorinostatvorinostat results in increased expression of MICA mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11323699  21712812  
GO:0030881beta-2-microglobulin bindingNOTIDA8901601  
GO:0046703natural killer cell lectin-like receptor binding-IBA21873635  
GO:0046703natural killer cell lectin-like receptor binding-IDA11491531  
GO:0046703natural killer cell lectin-like receptor binding-IPI10426993  
GO ID GO Term Qualifier Evidence PubMed
GO:0001913T cell mediated cytotoxicity-IBA21873635  
GO:0001913T cell mediated cytotoxicity-IDA10426993  
GO:0002418immune response to tumor cell-IDA10359807  
GO:0006955immune response-IBA21873635  
GO:0006974cellular response to DNA damage stimulus-IDA15995699  
GO:0009408response to heat-IDA8901601  
GO:0016032viral process-IEA-  
GO:0019835cytolysis-IEA-  
GO:0030101natural killer cell activation-IBA21873635  
GO:0032815negative regulation of natural killer cell activation-IDA20068167  
GO:0042267natural killer cell mediated cytotoxicity-IBA21873635  
GO:0042267natural killer cell mediated cytotoxicity-IDA10426993  
GO:0042271susceptibility to natural killer cell mediated cytotoxicity-IBA21873635  
GO:0042742defense response to bacterium-IDA11485740  11830641  
GO:0045953negative regulation of natural killer cell mediated cytotoxicity-IMP20068167  
GO:0046629gamma-delta T cell activation-IDA9497295  
GO:0050776regulation of immune response-TAS-  
GO:0051607defense response to virus-IDA11224526  16750166  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA18676862  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA18676862  
GO:0009986cell surface-IDA8901601  18676862  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10364115Oral contraceptives and myocardial infarction: results of the MICA case-control study. (1999 Jun 12)Dunn NBMJ
16738688Impact of gender on 24-h ambulatory blood pressure and target organ damage. (2006 Sep)Kotsis VJ Hum Hypertens
29721164Novel therapeutic features of disulfiram against hepatocellular carcinoma cells with inhibitory effects on a disintegrin and metalloproteinase 10. (2018 Apr 10)Goto KOncotarget