Gene: CDH8

1006
Nbla04261
cadherin 8
protein-coding
16q21
Ensembl:ENSG00000150394 MIM:603008 Vega:OTTHUMG00000137493 UniprotKB:P55286
NC_000016.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.189e-1 (AD)  3.450e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OLFM30.955
NRXN30.951
STYK10.949
FRMPD40.948
NEGR10.948
STXBP5L0.946
ATP8A20.946
GPR1580.945
NBEA0.945
SCN2A0.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.621
RAB13-0.615
HEY2-0.614
CSAG1-0.612
SYDE1-0.603
CHST14-0.602
YES1-0.594
EMP3-0.586
REST-0.585
MYL3-0.579

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH8 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH8 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH8 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH8 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH8 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH8 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CDH8 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDH8 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of CDH8 mRNA26705709
C015001arsenitearsenite results in increased methylation of CDH8 promoter23974009
C006780bisphenol Abisphenol A affects the expression of CDH8 mRNA20170705
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CDH8 promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of CDH8 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CDH8 gene28505145
D002101Cacodylic AcidCacodylic Acid results in decreased expression of CDH8 mRNA16122865
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CDH8 mRNA26472689
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDH8 gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of CDH8 mRNA19549813
C014347decitabinedecitabine affects the expression of CDH8 mRNA17145863
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CDH8 mRNA]27941970
D003976DiazinonDiazinon results in increased methylation of CDH8 gene22964155
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CDH8 promoter23359474
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CDH8 promoter23359474
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of CDH8 mRNA17374397
D004317DoxorubicinDoxorubicin affects the expression of CDH8 mRNA25529476
C118739entinostatentinostat results in decreased expression of CDH8 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH8 mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDH8 gene20938992
D004397FonofosFonofos results in increased methylation of CDH8 promoter22847954
D007854LeadLead affects the expression of CDH8 mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDH8 gene20938992
D008727MethotrexateMethotrexate affects the expression of CDH8 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CDH8 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CDH8 mRNA23179753|2718838
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of CDH8 mRNA12634122
D009151Mustard GasMustard Gas results in increased expression of CDH8 mRNA15674843
C029938nickel sulfatenickel sulfate results in decreased expression of CDH8 mRNA17374397
D010081OxazoloneOxazolone results in decreased expression of CDH8 mRNA17374397
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH8 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of CDH8 mRNA26272509
D010278ParathionParathion results in increased methylation of CDH8 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH8 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH8 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CDH8 mRNA26272509
D011441PropylthiouracilPropylthiouracil affects the expression of CDH8 mRNA24780913
C043680ptaquilosideptaquiloside results in decreased expression of CDH8 mRNA23274088
C017947sodium arsenitesodium arsenite results in increased methylation of CDH8 gene24118411
C012568terbufosterbufos results in increased methylation of CDH8 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CDH8 promoter]19654925
D013849ThimerosalThimerosal results in increased expression of CDH8 mRNA27188386
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH8 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CDH8 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH8 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of CDH8 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of CDH8 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CDH8 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IEA-  
GO:0008092cytoskeletal protein binding-IBA21873635  
GO:0042802identical protein binding-IEA-  
GO:0042803protein homodimerization activity-IBA21873635  
GO:0045296cadherin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IBA21873635  
GO:0007043cell-cell junction assembly-IBA21873635  
GO:0007155cell adhesion-TAS2059658  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0009409response to cold-IEA-  
GO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-IBA21873635  
GO:0034332adherens junction organization-IBA21873635  
GO:0034332adherens junction organization-TAS-  
GO:0035249synaptic transmission, glutamatergic-IBA21873635  
GO:0035249synaptic transmission, glutamatergic-IEA-  
GO:0044331cell-cell adhesion mediated by cadherin-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0009986cell surface-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0016342catenin complex-IBA21873635  
GO:0043083synaptic cleft-IBA21873635  
GO:0043083synaptic cleft-IEA-  
GO:0043679axon terminus-IBA21873635  
GO:0043679axon terminus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-418990Adherens junctions interactionsTAS
R-HSA-421270Cell-cell junction organizationTAS
R-HSA-446728Cell junction organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28823962Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer. (2017 Oct 28)Nakagawa TCancer Lett
23144319Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. (2013 Feb)Lee YCarcinogenesis