Gene: ABCC9

10060
ABC37|ATFB12|CANTU|CMD1O|SUR2
ATP binding cassette subfamily C member 9
protein-coding
12p12.1
Ensembl:ENSG00000069431 MIM:601439 Vega:OTTHUMG00000169094 UniprotKB:O60706
NG_012819.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.365e-1 (AD)  8.453e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OSMR0.78
FSTL10.776
PLSCR40.771
ITGA60.767
ANO60.766
RGL30.763
TMEM176B0.758
PRKD30.748
INHBB0.747
TNFRSF11B0.746

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CORT-0.526
GSG1-0.524
ADRA1D-0.524
HAS1-0.523
SLC1A6-0.517
ATOH7-0.513
NNAT-0.512
MARCH4-0.511
SPEF1-0.51
CRH-0.507

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
DB01016GlyburideSmall Molecule10238-21-8ApprovedTarget
DB09220NicorandilSmall Molecule65141-46-0Approved|InvestigationalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ABCC9 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ABCC9 mRNA"21346803
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ABCC9 mRNA"20816883
D000082AcetaminophenAcetaminophen results in decreased expression of ABCC9 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of ABCC9 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of ABCC9 mRNA17562736
D000255Adenosine TriphosphateAdenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]28842488
D000255Adenosine TriphosphateAdenosine Triphosphate results in decreased activity of [KCNJ8 protein binds to ABCC9 protein]28842488
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ABCC9 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ABCC9 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ABCC9 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ABCC9 mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of ABCC9 mRNA22323515
D001507BeclomethasoneBeclomethasone results in increased expression of ABCC9 mRNA23656298
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of ABCC9 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ABCC9 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ABCC9 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ABCC9 mRNA22228805
D004958EstradiolEstradiol binds to ABCC9 protein mutant form19095654
D004958EstradiolEstradiol inhibits the reaction [Glyburide binds to ABCC9 protein mutant form]19095654
C006780bisphenol Abisphenol A results in decreased methylation of ABCC9 promoter27312807
C006780bisphenol Abisphenol A affects the expression of ABCC9 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ABCC9 mRNA15901920|2909715
C006780bisphenol Abisphenol A results in increased methylation of ABCC9 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ABCC9 promoter22457795
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ABCC9 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ABCC9 mRNA17484886
D003042CocaineCocaine affects the expression of ABCC9 mRNA20187946
D019327Copper SulfateCopper Sulfate results in increased expression of ABCC9 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ABCC9 mRNA27989131
D003847DeoxyglucoseGlyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]28842488
D003847Deoxyglucose[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]28842488
D003981DiazoxideDiazoxide results in increased activity of ABCC9 protein21428460
D002945CisplatinCisplatin results in decreased expression of ABCC9 mRNA27594783
C121718dicyclanildicyclanil results in decreased expression of ABCC9 mRNA15664270
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCC9 mRNA17917374
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ABCC9 mRNA18164116
C067311docetaxel[docetaxel results in decreased susceptibility to docetaxel] which results in increased expression of ABCC9 mRNA19944135
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ABCC9 mRNA26159488
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ABCC9 mRNA15901920|2909715
D019833GenisteinGenistein results in increased expression of ABCC9 mRNA15901920
D005905GlyburideEstradiol inhibits the reaction [Glyburide binds to ABCC9 protein mutant form]19095654
D005905GlyburideGlyburide binds to ABCC9 protein mutant form19095654
D005905GlyburideGlyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]28842488
D005905GlyburideGlyburide results in decreased activity of ABCC9 protein22622455
D005905Glyburide[Glyburide results in decreased activity of ABCC9 protein] which results in increased expression of XDH protein22622455
D005905Glyburideresveratrol inhibits the reaction [Glyburide binds to ABCC9 protein]17138562
D005905GlyburideGlyburide binds to and results in decreased activity of ABCC9 protein15652236
D017313FenretinideFenretinide results in increased expression of ABCC9 mRNA28973697
C544151jinfukangjinfukang results in decreased expression of ABCC9 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ABCC9 mRNA24796395
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCC9 mRNA17917374
D008627Mercuric ChlorideMercuric Chloride results in increased activity of ABCC9 protein23690080
D008687Metformin[rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 mRNA alternative form20823565
D008687Metformin[rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 protein alternative form20823565
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ABCC9 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ABCC9 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ABCC9 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ABCC9 mRNA"25554681
D020108NicorandilNicorandil results in increased activity of ABCC9 protein22622455
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ABCC9 mRNA27935865
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of ABCC9 mRNA"12756304
D016627OxidopamineOxidopamine results in increased expression of ABCC9 mRNA15857625
D016627OxidopamineOxidopamine results in increased expression of ABCC9 protein15857625
D009840OligomycinsGlyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]28842488
D009840Oligomycins[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]28842488
C005290oxybenzoneoxybenzone results in increased activity of ABCC9 protein23690080
D010269ParaquatParaquat affects the expression of ABCC9 mRNA16854511
D010634PhenobarbitalPhenobarbital affects the expression of ABCC9 mRNA23091169
D010656PhenylephrinePhenylephrine results in decreased expression of ABCC9 mRNA18158353
D010795Phthalic AcidsPhthalic Acids results in increased expression of ABCC9 mRNA21061450
D020110PinacidilABCC9 affects the susceptibility to Pinacidil18511652
D020110PinacidilPinacidil results in increased activity of ABCC9 protein28842488
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ABCC9 mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ABCC9 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of ABCC9 mRNA19162173
D011188PotassiumABCC9 protein results in increased transport of Potassium10835035
D011374ProgesteroneProgesterone results in increased expression of ABCC9 mRNA20864642
D011374ProgesteroneProgesterone results in increased expression of ABCC9 mRNA20726854
D019269Phosphatidylinositol 4,5-Diphosphate"Phosphatidylinositol 4,5-Diphosphate results in increased activity of [KCNJ11 protein binds to ABCC9 protein]"28842488
C059514resveratrolresveratrol binds to ABCC9 protein17138562
C059514resveratrolresveratrol inhibits the reaction [Glyburide binds to ABCC9 protein]17138562
C013672riddelliineriddelliine results in decreased expression of ABCC9 mRNA18047727
C089730rosiglitazone[rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 mRNA alternative form20823565
C089730rosiglitazone[rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 protein alternative form20823565
C089730rosiglitazonerosiglitazone results in increased expression of ABCC9 mRNA alternative form20823565
C089730rosiglitazonerosiglitazone results in increased expression of ABCC9 protein alternative form20823565
D012413Rubidium[KCNJ11 protein binds to ABCC9 protein] which results in increased export of Rubidium28842488
D012413Rubidium[KCNJ8 protein binds to ABCC9 protein] which results in increased export of Rubidium28842488
C009277sodium arsenatesodium arsenate results in increased expression of ABCC9 mRNA21795629
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ABCC9 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABCC9 mRNA22298810
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ABCC9 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABCC9 mRNA21215274
D014050TolueneToluene results in increased expression of ABCC9 mRNA22967744
C011559tributyltintributyltin results in increased activity of ABCC9 protein23690080
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ABCC9 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of ABCC9 mRNA28973697
C406224valdecoxibvaldecoxib results in decreased expression of ABCC9 mRNA24136188
C025643vinclozolinvinclozolin results in increased expression of ABCC9 mRNA23034163
D019287Zinc SulfateZinc Sulfate results in decreased expression of ABCC9 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-TAS8826984  
GO:0005267potassium channel activityCONTRIBUTES_TOIBA21873635  
GO:0005524ATP binding-IEA-  
GO:0008281sulfonylurea receptor activity-ISS-  
GO:0015459potassium channel regulator activity-ISS-  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IBA21873635  
GO:0043225ATPase-coupled anion transmembrane transporter activity-TAS-  
GO:0044325ion channel binding-IPI20610380  
GO ID GO Term Qualifier Evidence PubMed
GO:0006813potassium ion transport-IBA21873635  
GO:0006813potassium ion transport-TAS8826984  
GO:0007165signal transduction-IEA-  
GO:0010107potassium ion import-ISS-  
GO:0042493response to drug-IBA21873635  
GO:0051607defense response to virus-IMP18026101  
GO:0055085transmembrane transport-IBA21873635  
GO:0055085transmembrane transport-TAS-  
GO:0099133ATP hydrolysis coupled anion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0008282inward rectifying potassium channel-IBA21873635  
GO:0008282inward rectifying potassium channel-IDA20610380  
GO:0008282inward rectifying potassium channel-ISS-  
GO:0016020membrane-IBA21873635  
GO:0030017sarcomere-IEA-  
GO:0042383sarcolemma-IBA21873635  
KEGG ID KEGG Term
hsa02010ABC transporters
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296025ATP sensitive Potassium channelsTAS
R-HSA-1296065Inwardly rectifying K+ channelsTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-5619084ABC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5678420Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasiaTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26333835Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration. (2015 Dec)Scheinfeldt LBAm J Med Genet B Neuropsychiatr Genet