Gene: NR1H3

10062
LXR-a|LXRA|RLD-1
nuclear receptor subfamily 1 group H member 3
protein-coding
11p11.2
Ensembl:ENSG00000025434 MIM:602423 Vega:OTTHUMG00000150628 UniprotKB:Q13133
NG_030392.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.761e-1 (AD)  6.437e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00347584chr11:47283025NR1H34.100e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSTB0.761
GSTP10.759
RNPEPL10.756
SLC25A10.754
RFXANK0.752
CD810.751
KRTCAP20.749
RGL20.749
PGLS0.746
CNPY40.744

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.6
OR4F29-0.569
PCDHAC1-0.28
PP2D1-0.275
ATP12A-0.269
CDH7-0.264
MAS1-0.264
IL1RAPL2-0.259
KLHL14-0.254
PPM1E-0.247

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB07080N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDESmall MoleculeExperimentalTarget
DB07929N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDESmall MoleculeExperimentalTarget
DB080631-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONESmall MoleculeExperimentalTarget
DB08175(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACIDSmall MoleculeExperimentalTarget
DB11994DiacereinSmall Molecule13739-02-1Approved|InvestigationalTarget
DB13174RheinSmall Molecule478-43-3ExperimentalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Androstanols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1H3 protein binds to MIR122 promoter]]"26171734
C00358522-hydroxycholesterol22-hydroxycholesterol binds to and results in increased activity of NR1H3 protein12932788
C00358522-hydroxycholesterol22-hydroxycholesterol inhibits the reaction [IFNG results in increased expression of NR1H3 mRNA]21268089
C00358522-hydroxycholesterol22-hydroxycholesterol promotes the reaction [pioglitazone results in increased expression of NR1H3 mRNA]15381068
C00358522-hydroxycholesterol22-hydroxycholesterol promotes the reaction [rosiglitazone results in increased expression of NR1H3 mRNA]15381068
C00358522-hydroxycholesterol22-hydroxycholesterol results in increased expression of NR1H3 mRNA15381068|2803480
C00358522-hydroxycholesterol[alitretinoin co-treated with 22-hydroxycholesterol] affects the localization of NR1H3 protein16888799
C00358522-hydroxycholesterol22-hydroxycholesterol binds to and results in increased activity of NR1H3 protein22156476
C00358522-hydroxycholesterol[22-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased export of Cholesterol22156476
C00358522-hydroxycholesterol22-hydroxycholesterol results in increased expression of NR1H3 protein22156476
C00358522-hydroxycholesterol22-hydroxycholesterol results in increased activity of NR1H3 protein9603267
C02835824,25-epoxycholesterol"NR1H3 protein promotes the reaction [24,25-epoxycholesterol results in increased abundance of Lipids]"20079722
C02835824,25-epoxycholesterol"24,25-epoxycholesterol binds to and affects the activity of NR1H3 protein"11290837
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of NR1H3 mRNA"23756648
C04456324-hydroxycholesterol[24-hydroxycholesterol co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA23732298
C04456324-hydroxycholesterol24-hydroxycholesterol binds to and affects the activity of NR1H3 protein11290837
C00799725-hydroxycholesterol[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA12595494
C00799725-hydroxycholesterol[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol12595494
C00799725-hydroxycholesterol25-hydroxycholesterol results in increased activity of NR1H3 protein27052460
C00799725-hydroxycholesterol[9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]12595494
C00799725-hydroxycholesterol[9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]12595494
C00799725-hydroxycholesterol[Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]12595494
C00799725-hydroxycholesterol[Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]12595494
C00799725-hydroxycholesterolSULT2B1 protein inhibits the reaction [25-hydroxycholesterol results in increased activity of NR1H3 protein]27052460
C00799725-hydroxycholesterol25-hydroxycholesterol results in increased activity of NR1H3 protein9603267
C00799725-hydroxycholesterol25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein12595494
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NR1H3 mRNA"21346803
C07699627-hydroxycholesterol27-hydroxycholesterol binds to and results in increased activity of NR1H3 protein22156476
C07699627-hydroxycholesterol[27-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased export of Cholesterol22156476
C07699627-hydroxycholesterol27-hydroxycholesterol results in increased expression of NR1H3 protein22156476
C07699627-hydroxycholesterol27-hydroxycholesterol results in increased expression of NR1H3 mRNA28167099
C07699627-hydroxycholesterol27-hydroxycholesterol results in increased expression of NR1H3 protein28167099
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [[CGA protein co-treated with FSHB protein co-treated with rosiglitazone] results in increased expression of NR1H3 mRNA]20926582
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [Niacin results in increased expression of NR1H3 mRNA]19797938
D0000737382-Hydroxypropyl-beta-cyclodextrin2-Hydroxypropyl-beta-cyclodextrin results in decreased expression of NR1H3 mRNA22156476
C0251603-aminobenzamide3-aminobenzamide results in decreased ADP-ribosylation of NR1H3 protein27026705
C0294353-hydroxy-5-cholestenoic acid3-hydroxy-5-cholestenoic acid affects the reaction [NR1H3 protein binds to NCOA2 protein]11089551
C0294353-hydroxy-5-cholestenoic acid3-hydroxy-5-cholestenoic acid binds to and results in increased activity of NR1H3 protein11089551
C1003244,4-dimethylcholesta-8,14,24-trienol"4,4-dimethylcholesta-8,14,24-trienol results in increased activity of NR1H3 protein"9603267
C5732335,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one"[Dietary Fats co-treated with 5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one] results in increased expression of NR1H3 mRNA"24646949
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1H3 protein]"27551952
C0469389,11-linoleic acid"9,11-linoleic acid results in increased expression of NR1H3 mRNA"15778275
C0371129-deoxy-delta-9-prostaglandin D2[9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]12595494
C0371129-deoxy-delta-9-prostaglandin D2[9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]12595494
C0371129-deoxy-delta-9-prostaglandin D2[9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] which results in increased expression of NR1H3 mRNA12595494
C099958acanthoic acidacanthoic acid results in increased expression of NR1H3 protein24802811
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NR1H3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NR1H3 mRNA27153756
C103303alitretinoin[alitretinoin co-treated with 22-hydroxycholesterol] affects the localization of NR1H3 protein16888799
C103303alitretinoinalitretinoin inhibits the reaction [IFNG results in increased expression of NR1H3 mRNA]21268089
D000493AllopurinolAllopurinol inhibits the reaction [Glucose results in increased expression of NR1H3 protein]23647015
D000493AllopurinolAllopurinol inhibits the reaction [Glucose results in increased expression of NR1H3 protein]23647015
D000493AllopurinolAllopurinol inhibits the reaction [Streptozocin results in increased expression of NR1H3 mRNA]23647015
D000493AllopurinolAllopurinol inhibits the reaction [Streptozocin results in increased expression of NR1H3 protein]23647015
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NR1H3 mRNA16483693
D000732Androstanols"Androstanols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1H3 protein binds to MIR122 promoter]]"26171734
D001151ArsenicNR1H3 gene mutant form results in decreased susceptibility to Arsenic25273567
C006632arsenic trioxidearsenic trioxide results in decreased activity of NR1H3 protein20339114
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA25932594
D001205Ascorbic Acidbexarotene promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]25932594
D001205Ascorbic Acidrosiglitazone promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]25932594
D001205Ascorbic Acidtributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]25932594
C512174atheronal-Aatheronal-A inhibits the reaction [TO-901317 results in increased activity of NR1H3 protein]27703007
C512174atheronal-Aatheronal-A results in increased lipidation of NR1H3 protein27703007
C512174atheronal-ANR1H3 gene mutant form promotes the reaction [Ozone results in increased chemical synthesis of atheronal-A]27703007
D001280AtrazineAtrazine results in decreased expression of NR1H3 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of NR1H3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NR1H3 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NR1H3 mRNA22228805
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA25932594
C031463beta-glycerophosphoric acidbexarotene promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]25932594
C031463beta-glycerophosphoric acidrosiglitazone promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]25932594
C031463beta-glycerophosphoric acidtributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]25932594
C095105bexarotenebexarotene promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]25932594
D001629Bezafibrate[Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]12595494
D001629Bezafibrate[Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]12595494
D001629Bezafibrate[Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of NR1H3 mRNA12595494
D001629BezafibrateBezafibrate results in increased expression of NR1H3 mRNA19201410
D001629BezafibrateNR1H3 protein affects the reaction [Bezafibrate results in increased expression of PPARA mRNA]19201410
D001629BezafibrateNR1H3 protein affects the susceptibility to Bezafibrate19201410
D001629BezafibrateBezafibrate results in increased expression of NR1H3 mRNA19124612|1920141
D001629BezafibrateNR1H3 protein affects the susceptibility to Bezafibrate19201410
D001629BezafibratePPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR1H3 mRNA]19124612
D001629BezafibrateBezafibrate inhibits the reaction [Dietary Fats results in increased expression of NR1H3 mRNA]26190035
D001647Bile Acids and SaltsNR1H3 protein affects the chemical synthesis of Bile Acids and Salts15725701
C006780bisphenol Abisphenol A affects the methylation of NR1H3 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of NR1H3 mRNA14967926|2193240
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of NR1H3 mRNA"23756648
C006780bisphenol Abisphenol A results in decreased expression of NR1H3 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of NR1H3 mRNA18958704
D000069286BortezomibBortezomib results in decreased expression of NR1H3 mRNA20977926
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H3 mRNA]17070507
D002104CadmiumCadmium results in decreased expression of NR1H3 mRNA28315714
D002104Cadmiumdecitabine inhibits the reaction [Cadmium results in decreased expression of NR1H3 mRNA]28315714
D002104CadmiumGW 3965 promotes the reaction [decitabine inhibits the reaction [Cadmium results in decreased expression of NR1H3 mRNA]]28315714
C534918CAY 10499NR1H3 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein]]23362264
C534918CAY 10499NR1H3 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased phosphorylation of LIPE protein]]23362264
C026690cerous chloridecerous chloride results in increased expression of NR1H3 mRNA23573234
D048271Chitosan[Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in increased expression of NR1H3 protein]28987369
D002784Cholesterol[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol12595494
D002784Cholesterol[9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]12595494
D002784Cholesterol[Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]12595494
D002784Cholesterol[Cholesterol co-treated with Ozone] results in increased lipidation of NR1H3 protein27703007
D002784Cholesterol[22-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased export of Cholesterol22156476
D002784Cholesterol[27-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased export of Cholesterol22156476
D002784Cholesterol[Desmosterol binds to and results in increased activity of NR1H3 protein] which results in increased export of Cholesterol22156476
D002784Cholesterol[TO-901317 binds to and results in increased activity of NR1H3 protein] which results in increased export of Cholesterol22156476
D002784Cholesterol"[Cholesterol, Dietary results in decreased expression of NR1H3 mRNA] which results in decreased export of Cholesterol"17395297
D002784CholesterolCholesterol results in decreased expression of NR1H3 mRNA17963637
D002784Cholesterol[Cholesterol results in decreased expression of NR1H3 mRNA] which results in decreased export of Cholesterol17963637
D002784Cholesterol"Niacin inhibits the reaction [[Cholesterol, Dietary results in decreased expression of NR1H3 mRNA] which results in decreased export of Cholesterol]"17395297
D002784CholesterolNiacin inhibits the reaction [Cholesterol results in decreased expression of NR1H3 mRNA]17963637
D002784CholesterolNiacin inhibits the reaction [[Cholesterol results in decreased expression of NR1H3 mRNA] which results in decreased export of Cholesterol]17963637
D002784Cholesterol[Niacin results in increased expression of NR1H3 mRNA] which results in increased export of Cholesterol17395297|1796363
D002784CholesterolNR1H3 protein affects the metabolism of Cholesterol15725701
D002784CholesterolNR1H3 protein affects the transport of Cholesterol15725701
D002791Cholesterol, Dietary"[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of NR1H3 protein"27394961
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of NR1H3 mRNA"28549616
D002791Cholesterol, Dietary"MET gene mutant form promotes the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of NR1H3 protein]"27394961
D002791Cholesterol, Dietary"Cholesterol, Dietary results in decreased expression of NR1H3 mRNA"17395297
D002791Cholesterol, Dietary"[Cholesterol, Dietary results in decreased expression of NR1H3 mRNA] which results in decreased export of Cholesterol"17395297
D002791Cholesterol, Dietary"Niacin inhibits the reaction [Cholesterol, Dietary results in decreased expression of NR1H3 mRNA]"17395297
D002791Cholesterol, Dietary"Niacin inhibits the reaction [[Cholesterol, Dietary results in decreased expression of NR1H3 mRNA] which results in decreased export of Cholesterol]"17395297
D002791Cholesterol, Dietary"[Cholesterol, Dietary co-treated with Cholic Acid] results in increased activity of NR1H3 protein"14684380
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased activity of NR1H3 protein"14684380
D008078Cholesterol, LDL"[TO-901317 binds to and results in increased activity of NR1H3 protein] which results in decreased uptake of Cholesterol, LDL"22156476
D019826Cholic Acid"[Cholesterol, Dietary co-treated with Cholic Acid] results in increased activity of NR1H3 protein"14684380
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of NR1H3 mRNA27344345
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of NR1H3 mRNA16197558
C019304ciprofibrateciprofibrate results in decreased expression of NR1H3 mRNA12771043
C503589cis-9, trans-11-conjugated linoleic acid"cis-9, trans-11-conjugated linoleic acid affects the expression of NR1H3 mRNA"17327424
D002994ClofibrateClofibrate results in decreased expression of NR1H3 mRNA28973556
D002994ClofibrateClofibrate results in increased expression of NR1H3 mRNA14690017
D002994ClofibrateKetoconazole inhibits the reaction [Clofibrate results in increased expression of NR1H3 mRNA]14690017
D009243NAD[PARP1 protein co-treated with NAD] results in increased ADP-ribosylation of NR1H3 protein27026705
D019327Copper SulfateCopper Sulfate results in decreased expression of NR1H3 mRNA19549813
D003474CurcuminCurcumin results in increased expression of NR1H3 mRNA16713233
D003513CycloheximideCycloheximide results in increased expression of NR1H3 mRNA19684285
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of NR1H3 mRNA19684285
D016572CyclosporineCyclosporine results in decreased expression of NR1H3 mRNA20106945|2556210
C014347decitabinedecitabine affects the expression of NR1H3 mRNA23300844
C014347decitabinedecitabine inhibits the reaction [Cadmium results in decreased expression of NR1H3 mRNA]28315714
C014347decitabineGW 3965 promotes the reaction [decitabine inhibits the reaction [Cadmium results in decreased expression of NR1H3 mRNA]]28315714
D003897DesmosterolDesmosterol binds to and results in increased activity of NR1H3 protein22156476
D003897Desmosterol[Desmosterol binds to and results in increased activity of NR1H3 protein] which results in increased export of Cholesterol22156476
D003897DesmosterolDesmosterol results in increased expression of NR1H3 protein22156476
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA25932594
D003907Dexamethasonebexarotene promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]25932594
D003907DexamethasoneDexamethasone results in increased expression of NR1H3 mRNA19022236|2504701
D003907Dexamethasonerosiglitazone promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]25932594
D003907Dexamethasonetributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]25932594
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of NR1H3 mRNA23428407
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA24848799
D003907DexamethasoneDexamethasone results in decreased expression of NR1H3 mRNA20888898
D003907DexamethasoneDexamethasone results in increased expression of NR1H3 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of NR1H3 mRNA]20032058
D003994BucladesineNR1H3 protein affects the reaction [Bucladesine results in increased phosphorylation of LIPE protein]23362264
D003994BucladesineNR1H3 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein]]23362264
D003994BucladesineNR1H3 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased phosphorylation of LIPE protein]]23362264
D002945CisplatinCisplatin affects the expression of NR1H3 mRNA23300844
D004041Dietary Fats"[Dietary Fats co-treated with 5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one] results in increased expression of NR1H3 mRNA"24646949
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of NR1H3 mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of NR1H3 mRNA27311796
D004041Dietary FatsDietary Fats results in increased expression of NR1H3 mRNA17932310|1845759
D004041Dietary FatsNFE2L2 protein affects the reaction [Dietary Fats results in decreased expression of NR1H3 mRNA]27311796
D004041Dietary Fats[Oligosaccharides co-treated with Dietary Fats] results in increased expression of NR1H3 protein28549616
D004041Dietary FatsOligosaccharides promotes the reaction [Dietary Fats results in increased expression of NR1H3 mRNA]28549616
D004041Dietary Fats"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of NR1H3 mRNA"23756648
D004041Dietary FatsBezafibrate inhibits the reaction [Dietary Fats results in increased expression of NR1H3 mRNA]26190035
D004041Dietary Fats[Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in increased expression of NR1H3 protein]28987369
D004041Dietary FatsDietary Fats results in increased expression of NR1H3 mRNA26190035
D004041Dietary FatsDietary Fats results in increased expression of NR1H3 protein28987369
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of NR1H3 mRNA28433925
D004051Diethylhexyl Phthalate[APOE gene mutant form results in increased susceptibility to Diethylhexyl Phthalate] which results in decreased expression of NR1H3 protein25270622
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of NR1H3 mRNA25949234
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of NR1H3 mRNA"23756648
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of NR1H3 mRNA12771043
D004642EmodinEmodin results in increased expression of NR1H3 mRNA26972667
D004642EmodinEmodin results in increased expression of NR1H3 protein26972667
D000431EthanolEthanol results in increased expression of NR1H3 mRNA23273579
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NR1H3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR1H3 mRNA17942748
D005047EtoposideEtoposide promotes the reaction [NR1H3 protein results in increased expression of CETP mRNA]25914138
D005047EtoposideEtoposide results in increased expression of and affects the localization of NR1H3 protein25914138
D005047EtoposideEtoposide results in increased expression of NR1H3 mRNA25914138
D005047EtoposideNR1H3 mutant form inhibits the reaction [Etoposide results in increased expression of CETP mRNA]25914138
D005047EtoposideNR1H3 protein affects the susceptibility to Etoposide25914138
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency promotes the reaction [NR1H3 gene mutant form results in increased expression of CD68 mRNA]"23333450
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency promotes the reaction [NR1H3 gene mutant form results in increased expression of TNF mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in decreased expression of ACAT1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in decreased expression of CYP3A11 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in decreased expression of ECI1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in decreased expression of NR1I3 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ACACA mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ACACA protein]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ACACB mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ACLY mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of AGPAT1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of CYP39A1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ELOVL6 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ELOVL6 protein]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of FADS2 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of FASN mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of FASN protein]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of LDLR mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ME1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of PLTP mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of PNPLA3 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of PPARD mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of SCD1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of SCD1 protein]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of THRSP mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential results in increased phosphorylation of ACLY protein]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of CD36 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of CYP51 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of FDFT1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of HSD17B7 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of IL1B mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of MSMO1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of NPC1L1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of NSDHL mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of SCD2 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of UCP2 mRNA]"23333450
D005231Fatty Acids, Unsaturated"Fatty Acids, Unsaturated binds to and results in decreased activity of NR1H3 protein"12970175
D011345FenofibrateFenofibrate results in increased expression of NR1H3 mRNA19201410
D011345FenofibrateNR1H3 protein affects the reaction [Fenofibrate results in increased expression of PPARA mRNA]19201410
D011345FenofibrateNR1H3 protein affects the susceptibility to Fenofibrate19201410
D011345Fenofibrate[Oleic Acid co-treated with Fenofibrate] affects the expression of NR1H3 mRNA24534255
D011345FenofibrateFenofibrate results in increased expression of NR1H3 mRNA19201410|2594923
D011345FenofibrateNR1H3 gene mutant form affects the reaction [Fenofibrate results in increased expression of ACACB mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form affects the reaction [Fenofibrate results in increased expression of SCD1 mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A10 mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A14 mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FDFT1 mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LSS mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of PPARA mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SQLE mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA]23063693
D011345FenofibrateNR1H3 protein affects the susceptibility to Fenofibrate19201410
D011345FenofibratePPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of NR1H3 mRNA]25949234
D018120FinasterideFinasteride results in increased expression of NR1H3 mRNA24136188
D005395Fish Oils[Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in increased expression of NR1H3 protein]28987369
D005419FlavonoidsFlavonoids results in increased expression of NR1H3 mRNA18035473
D015248GemfibrozilGemfibrozil results in increased expression of NR1H3 mRNA19201410
D015248GemfibrozilNR1H3 protein affects the reaction [Gemfibrozil results in increased expression of PPARA mRNA]19201410
D015248GemfibrozilNR1H3 protein affects the susceptibility to Gemfibrozil19201410
D015248GemfibrozilGemfibrozil results in increased expression of NR1H3 mRNA19201410
D015248GemfibrozilNR1H3 protein affects the susceptibility to Gemfibrozil19201410
D015248GemfibrozilGemfibrozil results in increased expression of NR1H3 protein15998575
D019833GenisteinGenistein promotes the reaction [NR1H3 protein binds to SULT2A1 promoter]23352501
D019833GenisteinNR1H3 protein affects the reaction [Genistein results in increased expression of SULT2A1 mRNA]23352501
D019833GenisteinNR1H3 protein affects the reaction [Genistein results in increased expression of SULT2A1 protein]23352501
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate results in decreased activity of NR1H3 protein22607622
D005947GlucoseAllopurinol inhibits the reaction [Glucose results in increased expression of NR1H3 protein]23647015
D005947GlucoseGlucose results in increased expression of NR1H3 protein23647015
D005947GlucoseQuercetin inhibits the reaction [Glucose results in increased expression of NR1H3 protein]23647015
D005947GlucoseAllopurinol inhibits the reaction [Glucose results in increased expression of NR1H3 protein]23647015
D005947GlucoseGlucose results in increased expression of NR1H3 protein23647015
D005947GlucoseQuercetin inhibits the reaction [Glucose results in increased expression of NR1H3 protein]23647015
C504517GSK 3987GSK 3987 binds to and results in increased activity of NR1H3 protein16107141
C504517GSK 3987GSK 3987 binds to NR1H3 protein16107141
C473027GW 3965GW 3965 binds to and results in increased activity of NR1H3 protein12932788
C473027GW 3965[GW 3965 co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA23732298
C473027GW 3965GW 3965 results in increased expression of NR1H3 mRNA17449538|2373229
C473027GW 3965NR1H3 mutant form inhibits the reaction [GW 3965 results in increased expression of ABCA1 mRNA]23732298
C473027GW 3965GW 3965 binds to and results in increased activity of NR1H3 protein15633131
C473027GW 3965GW 3965 promotes the reaction [decitabine inhibits the reaction [Cadmium results in decreased expression of NR1H3 mRNA]]28315714
C473027GW 3965GW 3965 results in increased activity of NR1H3 protein17420776
C425931GW 501516GW 501516 results in increased expression of NR1H3 mRNA19201410
C425931GW 501516NR1H3 protein affects the reaction [GW 501516 results in increased expression of PPARA mRNA]19201410
C425931GW 501516NR1H3 protein affects the susceptibility to GW 50151619201410
C425931GW 501516GW 501516 results in increased expression of NR1H3 mRNA19201410
C425931GW 501516NR1H3 protein affects the susceptibility to GW 50151619201410
C070164homocastasterone[homocastasterone analog co-treated with Streptozocin] results in increased expression of NR1H3 mRNA28822685
C070164homocastasterone[homocastasterone analog co-treated with Streptozocin] results in increased expression of NR1H3 protein28822685
C070164homocastasteronehomocastasterone analog results in increased expression of NR1H3 mRNA28822685
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NR1H3 mRNA17183730
C541917INT 131INT 131 results in increased expression of NR1H3 mRNA19452630
C051140iron(II)-ascorbic acid complexButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H3 mRNA]17070507
C051140iron(II)-ascorbic acid complexiron(II)-ascorbic acid complex results in decreased expression of NR1H3 mRNA17070507
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of NR1H3 mRNA23428407
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA24848799
D007654KetoconazoleKetoconazole inhibits the reaction [TO-901317 results in increased activity of NR1H3 protein]16819505
D007654KetoconazoleKetoconazole inhibits the reaction [Clofibrate results in increased expression of NR1H3 mRNA]14690017
D064747LansoprazoleLansoprazole results in increased activity of NR1H3 protein20060385
C017461lead nitratelead nitrate results in decreased expression of NR1H3 mRNA15475176
C045463leflunomideleflunomide results in increased expression of NR1H3 mRNA24136188
D008055Lipids"NR1H3 protein promotes the reaction [24,25-epoxycholesterol results in increased abundance of Lipids]"20079722
D008055LipidsNR1H3 protein promotes the reaction [paxilline results in increased abundance of Lipids]20079722
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [rosiglitazone results in increased expression of NR1H3 mRNA]22240665
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NR1H3 mRNA16847310|2224066
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NR1H3 protein21689150
D008070LipopolysaccharidesMelatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1H3 protein]21689150
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NR1H3 mRNA21939782
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NR1H3 protein21939782
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLC51A mRNA]17256725
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLCO1B2 mRNA]17256725
D008095Lithocholic AcidLithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCB11 mRNA]17256725
D008095Lithocholic AcidLithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCC4 mRNA]17256725
D008095Lithocholic AcidLithocholic Acid results in decreased expression of NR1H3 mRNA20359477
D008095Lithocholic AcidNR1H3 protein inhibits the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]17256725
D008095Lithocholic AcidNR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC10A2 mRNA]17256725
D008095Lithocholic AcidNR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA]17256725
D008095Lithocholic AcidNR1H3 protein results in decreased susceptibility to Lithocholic Acid17256725
D008095Lithocholic AcidLithocholic Acid results in decreased expression of NR1H3 mRNA20888898
C479889LY 518674LY 518674 results in increased expression of NR1H3 mRNA19201410
C479889LY 518674NR1H3 protein affects the reaction [LY 518674 results in increased expression of PPARA mRNA]19201410
C479889LY 518674NR1H3 protein affects the susceptibility to LY 51867419201410
C479889LY 518674LY 518674 results in increased expression of NR1H3 mRNA19201410
C479889LY 518674NR1H3 protein affects the susceptibility to LY 51867419201410
D008550MelatoninMelatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1H3 protein]21689150
D008731MethoxychlorMethoxychlor results in decreased expression of NR1H3 mRNA21276474
D008748MethylcholanthreneMethylcholanthrene results in increased expression of NR1H3 mRNA23273579
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NR1H3 mRNA28001369
D008777MethyltestosteroneMethyltestosterone results in increased expression of NR1H3 mRNA29191790
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1H3 protein]27551952
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of NR1H3 mRNA23118965
C471400monoisononylphthalatemonoisononylphthalate promotes the reaction [NCOA1 protein binds to and results in increased activity of NR1H3 protein]27551952
C500085muraglitazar[Oleic Acid co-treated with muraglitazar] results in increased expression of NR1H3 mRNA24534255
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of NR1H3 mRNA27344345
D009525NiacinNiacin results in increased expression of NR1H3 mRNA15037193
D009525NiacinPPARG protein promotes the reaction [Niacin results in increased expression of NR1H3 mRNA]15037193
D009525Niacin2-chloro-5-nitrobenzanilide inhibits the reaction [Niacin results in increased expression of NR1H3 mRNA]19797938
D009525NiacinNiacin results in increased expression of NR1H3 mRNA19797938
D009525NiacinPPARG protein promotes the reaction [Niacin results in increased expression of NR1H3 mRNA]19797938
D009525Niacin"Niacin inhibits the reaction [Cholesterol, Dietary results in decreased expression of NR1H3 mRNA]"17395297
D009525Niacin"Niacin inhibits the reaction [[Cholesterol, Dietary results in decreased expression of NR1H3 mRNA] which results in decreased export of Cholesterol]"17395297
D009525NiacinNiacin inhibits the reaction [Cholesterol results in decreased expression of NR1H3 mRNA]17963637
D009525NiacinNiacin inhibits the reaction [[Cholesterol results in decreased expression of NR1H3 mRNA] which results in decreased export of Cholesterol]17963637
D009525NiacinNiacin results in increased expression of NR1H3 mRNA17395297|1796363
D009525Niacin[Niacin results in increased expression of NR1H3 mRNA] which results in increased export of Cholesterol17395297|1796363
D009532NickelNickel results in decreased expression of NR1H3 mRNA24768652|2558310
D009538NicotineNicotine promotes the reaction [NR1H3 protein binds to FASN promoter]24368177
D009538NicotineNicotine results in increased expression of and results in increased activity of NR1H3 protein24368177
D019301Oleic Acid[Oleic Acid co-treated with Fenofibrate] affects the expression of NR1H3 mRNA24534255
D019301Oleic Acid[Oleic Acid co-treated with muraglitazar] results in increased expression of NR1H3 mRNA24534255
D019301Oleic Acid[Oleic Acid co-treated with rosiglitazone] results in increased expression of NR1H3 mRNA24534255
D019301Oleic Acid[Oleic Acid co-treated with tesaglitazar] affects the expression of NR1H3 mRNA24534255
D019301Oleic Acid[Oleic Acid co-treated with troglitazone] affects the expression of NR1H3 mRNA24534255
D019301Oleic Acid[Oleic Acid co-treated with Palmitic Acid] results in increased expression of NR1H3 mRNA26190035
D009844Oligosaccharides[Oligosaccharides co-treated with Dietary Fats] results in increased expression of NR1H3 protein28549616
D009844OligosaccharidesOligosaccharides promotes the reaction [Dietary Fats results in increased expression of NR1H3 mRNA]28549616
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 promotes the reaction [NR1H3 gene mutant form results in increased expression of TNF mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of ELOVL5 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of FASN protein]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of IL1B mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of NR1I2 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of PCK1 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of PNPLA3 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of ACACB mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of and results in decreased phosphorylation of ACLY protein]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of CRP mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of FADS2 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of MLXIPL mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of SCD1 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of SCD1 protein]"23333450
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of NR1H3 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of NR1H3 mRNA25729387
D010126Ozone[Cholesterol co-treated with Ozone] results in increased lipidation of NR1H3 protein27703007
D010126OzoneNR1H3 gene mutant form promotes the reaction [Ozone results in increased chemical synthesis of atheronal-A]27703007
D010126OzoneNR1H3 gene mutant form promotes the reaction [Ozone results in increased expression of and results in increased secretion of IL6 protein]27703007
D010126OzoneNR1H3 gene mutant form promotes the reaction [Ozone results in increased expression of IL6 mRNA]27703007
C053370paclobutrazolpaclobutrazol results in increased expression of NR1H3 mRNA23202249
D019308Palmitic Acid[Oleic Acid co-treated with Palmitic Acid] results in increased expression of NR1H3 mRNA26190035
C048220paxillineNR1H3 protein promotes the reaction [paxilline results in increased abundance of Lipids]20079722
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of NR1H3 mRNA21705711
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of NR1H3 mRNA25949234
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of NR1H3 mRNA25949234
C584865perfluorononanoic acidPPARA gene mutant form promotes the reaction [perfluorononanoic acid results in increased expression of NR1H3 mRNA]25949234
C076994perfluorooctane sulfonic acidNR1H3 gene mutant form inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of CYP4A10 mRNA]25949234
C076994perfluorooctane sulfonic acidNR1H3 gene mutant form inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of GSTM3 mRNA]25949234
C076994perfluorooctane sulfonic acid[NR1H3 gene mutant form results in increased susceptibility to perfluorooctane sulfonic acid] which results in increased expression of ACOX1 mRNA25949234
C076994perfluorooctane sulfonic acid[NR1H3 gene mutant form results in increased susceptibility to perfluorooctane sulfonic acid] which results in increased expression of GSTA2 mRNA25949234
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NR1H3 mRNA21705711
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of NR1H3 mRNA25949234
C076994perfluorooctane sulfonic acidPPARA gene mutant form promotes the reaction [perfluorooctane sulfonic acid results in increased expression of NR1H3 mRNA]25949234
C023036perfluorooctanoic acidNR1H3 gene mutant form inhibits the reaction [perfluorooctanoic acid results in increased expression of CYP2B10 mRNA]25949234
C023036perfluorooctanoic acidNR1H3 gene mutant form results in increased susceptibility to perfluorooctanoic acid25949234
C023036perfluorooctanoic acid[NR1H3 gene mutant form results in increased susceptibility to perfluorooctanoic acid] which results in increased expression of CYP3A11 mRNA25949234
C023036perfluorooctanoic acid[NR1H3 gene mutant form results in increased susceptibility to perfluorooctanoic acid] which results in increased expression of GSTM3 mRNA25949234
C023036perfluorooctanoic acidNR1H3 protein affects the reaction [perfluorooctanoic acid results in increased expression of BIRC5 mRNA]25949234
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NR1H3 mRNA17681415
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of NR1H3 mRNA25949234
C023036perfluorooctanoic acidPPARA gene mutant form promotes the reaction [perfluorooctanoic acid results in increased expression of NR1H3 mRNA]25949234
D010575PesticidesPesticides results in increased activity of NR1H3 protein20143881
D010634PhenobarbitalPhenobarbital results in increased expression of NR1H3 mRNA23273579
C060836pioglitazone22-hydroxycholesterol promotes the reaction [pioglitazone results in increased expression of NR1H3 mRNA]15381068
C060836pioglitazoneNR1H3 protein affects the reaction [pioglitazone results in increased expression of PPARA mRNA]19201410
C060836pioglitazoneNR1H3 protein affects the susceptibility to pioglitazone19201410
C060836pioglitazonepioglitazone results in increased expression of NR1H3 mRNA15381068|1920141
C060836pioglitazoneNR1H3 protein affects the susceptibility to pioglitazone19201410
C060836pioglitazonepioglitazone results in increased expression of NR1H3 mRNA19201410
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NR1H3 mRNA12595494
C006253pirinixic acidpirinixic acid results in increased expression of NR1H3 mRNA25949234
C006253pirinixic acidPPARA gene mutant form inhibits the reaction [pirinixic acid results in increased expression of NR1H3 mRNA]25949234
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of NR1H3 mRNA20888898
C045950propiconazoleNR1H3 gene mutant form inhibits the reaction [propiconazole results in increased expression of CYP2B10 mRNA]25949234
C045950propiconazoleNR1H3 gene mutant form promotes the reaction [propiconazole results in increased expression of GSTM3 mRNA]25949234
D011441PropylthiouracilPropylthiouracil results in decreased expression of NR1H3 mRNA24780913
C432165pyrazolanthronepyrazolanthrone results in increased expression of NR1H3 mRNA19883121
D011794QuercetinQuercetin inhibits the reaction [Glucose results in increased expression of NR1H3 protein]23647015
D011794QuercetinMAPK14 protein promotes the reaction [Quercetin promotes the reaction [NR1H3 protein binds to ABCA1 promoter]]22711909
D011794QuercetinQuercetin promotes the reaction [SP1 protein binds to NR1H3 promoter]22711909
D011794QuercetinQuercetin inhibits the reaction [Glucose results in increased expression of NR1H3 protein]23647015
D011794QuercetinQuercetin inhibits the reaction [Streptozocin results in increased expression of NR1H3 mRNA]23647015
D011794QuercetinQuercetin inhibits the reaction [Streptozocin results in increased expression of NR1H3 protein]23647015
C059514resveratrolADORA2A protein promotes the reaction [resveratrol results in increased expression of NR1H3 protein]23041272
C059514resveratrolresveratrol inhibits the reaction [TO-901317 results in increased expression of NR1H3 mRNA]23651738
C059514resveratrolresveratrol results in increased expression of NR1H3 mRNA16901463
C059514resveratrolresveratrol results in increased expression of NR1H3 protein16901463|2304127
C059514resveratrolZM 241385 inhibits the reaction [resveratrol results in increased expression of NR1H3 protein]23041272
C059514resveratrolNR1H3 protein promotes the reaction [resveratrol results in increased expression of CYP7A1 mRNA]22607622
C059514resveratrolresveratrol results in decreased expression of NR1H3 mRNA22659145
C059514resveratrolresveratrol results in increased activity of NR1H3 protein22607622
C059514resveratrol[resveratrol results in increased activity of NR1H3 protein] which results in increased expression of CYP7A1 mRNA22607622
D012293RifampinNR1H3 mutant form inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]23732298
C089730rosiglitazone22-hydroxycholesterol promotes the reaction [rosiglitazone results in increased expression of NR1H3 mRNA]15381068
C089730rosiglitazone[Oleic Acid co-treated with rosiglitazone] results in increased expression of NR1H3 mRNA24534255
C089730rosiglitazonerosiglitazone promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]25932594
C089730rosiglitazonerosiglitazone results in increased expression of NR1H3 mRNA15314095|1538106
C089730rosiglitazone2-chloro-5-nitrobenzanilide inhibits the reaction [[CGA protein co-treated with FSHB protein co-treated with rosiglitazone] results in increased expression of NR1H3 mRNA]20926582
C089730rosiglitazone[CGA protein co-treated with FSHB protein co-treated with rosiglitazone] results in increased expression of NR1H3 mRNA20926582
C089730rosiglitazoneLipopolysaccharides inhibits the reaction [rosiglitazone results in increased expression of NR1H3 mRNA]22240665
C089730rosiglitazonerosiglitazone results in increased expression of NR1H3 mRNA19452630|2224066
C089730rosiglitazonerosiglitazone results in increased expression of NR1H3 protein15998575
C093642SB 203580SB 203580 results in increased expression of NR1H3 mRNA19883121
D019821SimvastatinSimvastatin results in decreased expression of NR1H3 mRNA22160096
D020123SirolimusSirolimus affects the expression of NR1H3 protein17016853
C017947sodium arsenitesodium arsenite results in decreased expression of NR1H3 mRNA19822182
D020358Sodium Cholate"[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of NR1H3 protein"27394961
D020358Sodium Cholate"MET gene mutant form promotes the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of NR1H3 protein]"27394961
D013311StreptozocinAllopurinol inhibits the reaction [Streptozocin results in increased expression of NR1H3 mRNA]23647015
D013311StreptozocinAllopurinol inhibits the reaction [Streptozocin results in increased expression of NR1H3 protein]23647015
D013311Streptozocin[homocastasterone analog co-treated with Streptozocin] results in increased expression of NR1H3 mRNA28822685
D013311Streptozocin[homocastasterone analog co-treated with Streptozocin] results in increased expression of NR1H3 protein28822685
D013311StreptozocinQuercetin inhibits the reaction [Streptozocin results in increased expression of NR1H3 mRNA]23647015
D013311StreptozocinQuercetin inhibits the reaction [Streptozocin results in increased expression of NR1H3 protein]23647015
D013311StreptozocinStreptozocin results in increased expression of NR1H3 mRNA23647015
D013311StreptozocinStreptozocin results in increased expression of NR1H3 protein23647015
D013713TeniposideNR1H3 mutant form inhibits the reaction [Teniposide results in increased expression of CETP mRNA]25914138
D013713TeniposideNR1H3 protein affects the susceptibility to Teniposide25914138
D013713TeniposideTeniposide promotes the reaction [NR1H3 protein results in increased expression of CETP mRNA]25914138
D013713TeniposideTeniposide results in increased expression of and affects the localization of NR1H3 protein25914138
D013713TeniposideTeniposide results in increased expression of NR1H3 mRNA25914138
C501413tesaglitazar[Oleic Acid co-treated with tesaglitazar] affects the expression of NR1H3 mRNA24534255
D013739TestosteroneTestosterone results in decreased expression of NR1H3 mRNA20844152
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of NR1H3 mRNA]20032058
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of NR1H3 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NR1H3 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NR1H3 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of NR1H3 mRNA"23756648
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR1H3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NR1H3 mRNA19770486|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NR1H3 mRNA18796159
C017953tetramethylpyrazinetetramethylpyrazine results in increased expression of NR1H3 mRNA28034800
D013853ThioacetamideThioacetamide results in increased expression of NR1H3 mRNA26222700
C009495titanium dioxidetitanium dioxide results in increased expression of NR1H3 mRNA23409001
C423915TO-901317atheronal-A inhibits the reaction [TO-901317 results in increased activity of NR1H3 protein]27703007
C423915TO-901317Ketoconazole inhibits the reaction [TO-901317 results in increased activity of NR1H3 protein]16819505
C423915TO-901317NR1H3 protein affects the reaction [TO-901317 results in increased expression of PPARA mRNA]19201410
C423915TO-901317NR1H3 protein affects the susceptibility to TO-90131719201410
C423915TO-901317NR1H3 protein inhibits the reaction [[TO-901317 co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA]23732298
C423915TO-901317resveratrol inhibits the reaction [TO-901317 results in increased expression of NR1H3 mRNA]23651738
C423915TO-901317RXRA protein promotes the reaction [[TO-901317 co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA]23732298
C423915TO-901317TO-901317 binds to and results in increased activity of NR1H3 protein12932788|1297017
C423915TO-901317[TO-901317 co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA23732298
C423915TO-901317TO-901317 promotes the reaction [[NR1H3 protein binds to NR1H2 protein] which binds to SREBF1 promoter]15548517
C423915TO-901317TO-901317 results in increased activity of NR1H3 protein16819505|1725672
C423915TO-901317[TO-901317 results in increased activity of NR1H3 protein] which results in decreased expression of CYP7B1 mRNA17256725
C423915TO-901317TO-901317 results in increased expression of NR1H3 mRNA17449538|2365173
C423915TO-901317TO-901317 results in increased expression of NR1H3 protein25980575
C423915TO-901317"[TO-901317 binds to and results in increased activity of NR1H3 protein] which results in decreased uptake of Cholesterol, LDL"22156476
C423915TO-901317[TO-901317 binds to and results in increased activity of NR1H3 protein] which results in increased export of Cholesterol22156476
C423915TO-901317TO-901317 binds to and results in increased expression of and results in increased activity of NR1H3 protein22156476
C423915TO-901317TO-901317 results in increased expression of NR1H3 mRNA22156476
C423915TO-901317TO-901317 binds to and results in increased activity of NR1H3 protein21291553
C423915TO-901317NR1H3 gene mutant form inhibits the reaction [TO-901317 results in increased expression of ACACA mRNA]23063693|2333345
C423915TO-901317NR1H3 gene mutant form inhibits the reaction [TO-901317 results in increased expression of ACACB mRNA]23063693
C423915TO-901317NR1H3 gene mutant form inhibits the reaction [TO-901317 results in increased expression of ACLY mRNA]23063693|2333345
C423915TO-901317NR1H3 gene mutant form inhibits the reaction [TO-901317 results in increased expression of ELOVL6 mRNA]23063693|2333345
C423915TO-901317NR1H3 gene mutant form inhibits the reaction [TO-901317 results in increased expression of FASN mRNA]23063693|2333345
C423915TO-901317NR1H3 gene mutant form inhibits the reaction [TO-901317 results in increased expression of ME1 mRNA]23063693|2333345
C423915TO-901317NR1H3 gene mutant form inhibits the reaction [TO-901317 results in increased expression of PNPLA3 mRNA]23333450
C423915TO-901317NR1H3 gene mutant form inhibits the reaction [TO-901317 results in increased expression of SCD1 mRNA]23063693|2333345
C423915TO-901317NR1H3 gene mutant form inhibits the reaction [TO-901317 results in increased expression of SCD2 mRNA]23063693
C423915TO-901317NR1H3 gene mutant form inhibits the reaction [TO-901317 results in increased expression of THRSP mRNA]23333450
C423915TO-901317TO-901317 binds to and results in increased activity of NR1H3 protein17256725|2228935
C423915TO-901317TO-901317 results in increased activity of NR1H3 protein27026705
C423915TO-901317TO-901317 results in increased expression of NR1H3 mRNA22240665
C423915TO-901317TO-901317 binds to and results in increased activity of NR1H3 protein17088262|1950918
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of NR1H3 mRNA25729387
D019772TopotecanTopotecan results in increased expression of NR1H3 mRNA25729387
D014212TretinoinTretinoin results in increased expression of NR1H3 mRNA16054129
C032910triadimefonNR1H3 gene mutant form inhibits the reaction [triadimefon results in increased expression of BIRC5 mRNA]25949234
C032910triadimefonNR1H3 gene mutant form inhibits the reaction [triadimefon results in increased expression of CYP2B10 mRNA]25949234
C032910triadimefonNR1H3 gene mutant form inhibits the reaction [triadimefon results in increased expression of CYP3A11 mRNA]25949234
C032910triadimefonNR1H3 gene mutant form promotes the reaction [triadimefon results in increased expression of GSTM3 mRNA]25949234
C011559tributyltintributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]25932594
C011559tributyltintributyltin results in increased expression of NR1H3 mRNA28011154
C011559tributyltintributyltin results in increased expression of NR1H3 mRNA23428407|2484879
C057693troglitazone[Oleic Acid co-treated with troglitazone] affects the expression of NR1H3 mRNA24534255
C113580U 0126U 0126 inhibits the reaction [TNF protein results in decreased expression of NR1H3 mRNA]19883121
C113580U 0126U 0126 results in increased expression of NR1H3 mRNA19883121
D014501UraniumUranium results in increased expression of NR1H3 mRNA16231126
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NR1H3 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of NR1H3 mRNA25979313
D015032ZincZinc results in decreased expression of NR1H3 mRNA18316168
D015034Zinc OxideZinc Oxide affects the expression of NR1H3 protein28648595
C097270ZM 241385ZM 241385 inhibits the reaction [resveratrol results in increased expression of NR1H3 protein]23041272
D015054ZymosanZymosan results in decreased expression of NR1H3 mRNA16847310

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001076transcription factor activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0003677DNA binding-TAS7744246  
GO:0003700DNA-binding transcription factor activityCONTRIBUTES_TOIBA21873635  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0003713transcription coactivator activity-IDA19481530  
GO:0004879nuclear receptor activity-IBA21873635  
GO:0004879nuclear receptor activity-TAS7744246  
GO:0005515protein binding-IPI12040021  19481530  20219900  20682316  21516116  23455924  
25416956  25661920  25962847  26120082  
GO:0008134transcription factor binding-IBA21873635  
GO:0008270zinc ion binding-IEA-  
GO:0008289lipid binding-IBA21873635  
GO:0015485cholesterol binding-TAS11090131  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IBA21873635  
GO:0032810sterol response element binding-IDA19628791  
GO:0044212transcription regulatory region DNA binding-IDA19229075  
GO:0044212transcription regulatory region DNA bindingcontributes_toIDA18511497  
GO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006629lipid metabolic process-IBA21873635  
GO:0007275multicellular organism development-IBA21873635  
GO:0010745negative regulation of macrophage derived foam cell differentiation-IC17693624  
GO:0010867positive regulation of triglyceride biosynthetic process-IMP17693624  
GO:0010870positive regulation of receptor biosynthetic process-IDA18511497  
GO:0010875positive regulation of cholesterol efflux-IDA16141411  19481530  
GO:0010875positive regulation of cholesterol efflux-IMP17186944  
GO:0010887negative regulation of cholesterol storage-IMP17693624  
GO:0030154cell differentiation-IBA21873635  
GO:0030522intracellular receptor signaling pathway-IEA-  
GO:0032270positive regulation of cellular protein metabolic process-IMP17186944  
GO:0032369negative regulation of lipid transport-IMP17693624  
GO:0032376positive regulation of cholesterol transport-IDA16141411  
GO:0032570response to progesterone-IDA16141411  
GO:0033993response to lipid-IBA21873635  
GO:0034145positive regulation of toll-like receptor 4 signaling pathway-IDA18511497  
GO:0042632cholesterol homeostasis-IBA21873635  
GO:0042632cholesterol homeostasis-IDA18511497  
GO:0042632cholesterol homeostasis-ISS-  
GO:0042752regulation of circadian rhythm-TAS18511497  
GO:0043031negative regulation of macrophage activation-ISS-  
GO:0043277apoptotic cell clearance-IMP19628791  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0045723positive regulation of fatty acid biosynthetic process-IMP17186944  
GO:0045893positive regulation of transcription, DNA-templated-IDA25661920  
GO:0045893positive regulation of transcription, DNA-templated-IMP19628791  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16141411  18511497  19481530  20219900  20837115  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP17186944  19229075  
GO:0048550negative regulation of pinocytosis-IMP17693624  
GO:0050728negative regulation of inflammatory response-IBA21873635  
GO:0050728negative regulation of inflammatory response-ISS-  
GO:0051006positive regulation of lipoprotein lipase activity-IMP17186944  
GO:0055088lipid homeostasis-IBA21873635  
GO:0055088lipid homeostasis-ISS-  
GO:0055092sterol homeostasis-ISS-  
GO:0060336negative regulation of interferon-gamma-mediated signaling pathway-NAS21268089  
GO:0070328triglyceride homeostasis-ISS-  
GO:0071222cellular response to lipopolysaccharide-IBA21873635  
GO:0071222cellular response to lipopolysaccharide-IDA18511497  
GO:0090188negative regulation of pancreatic juice secretion-ISS-  
GO:0090341negative regulation of secretion of lysosomal enzymes-ISS-  
GO:2000325regulation of ligand-dependent nuclear receptor transcription coactivator activity-IDA19481530  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA18511497  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA25661920  
GO:0005654nucleoplasm-TAS-  
GO:0043235receptor complex-IDA18511497  
GO:0090575RNA polymerase II transcription factor complex-IBA21873635  
GO:0090575RNA polymerase II transcription factor complex-IDA18511497  
KEGG ID KEGG Term
hsa03320PPAR signaling pathway
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1368082RORA activates gene expressionTAS
R-HSA-1430728MetabolismTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400253Circadian ClockTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8866427VLDLR internalisation and degradationTAS
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-8964043Plasma lipoprotein clearanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20836841Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes. (2010 Sep 13)Andersen VBMC Cancer