Gene info: ID 10068

Gene: IL18BP

GENE ID: 10068

Synonyms: IL18BPa

Description: interleukin 18 binding protein

Gene type: protein-coding

Location: 11q13.4

dbXrefs: Ensembl:ENSG00000137496 MIM:604113 Vega:OTTHUMG00000133713 UniprotKB:O95998

RefSeq: NG_029021.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.592e-2 (AD) 5.238e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NLRC5	0.893
TAP1	0.88
GBP1	0.87
C1R	0.863
TRIM5	0.859
APOL6	0.849
PML	0.845
GBP2	0.843
C1S	0.839
DTX3L	0.839

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CPLX3	-0.379
HES5	-0.36
KIT	-0.357
KCNIP3	-0.354
ARSF	-0.345
CYP1A1	-0.336
HAPLN1	-0.33
EDN3	-0.325
ACY3	-0.324
CRH	-0.32

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C070046	1,2-dioleoyloxy-3-(trimethylammonium)propane	"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of IL18BP mRNA"	22129739
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of IL18BP mRNA"	18648102
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of IL18BP gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of IL18BP mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of IL18BP mRNA	24449571
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IL18BP mRNA	22228805
C044887	beta-methylcholine	beta-methylcholine affects the expression of IL18BP mRNA	21179406
C006780	bisphenol A	bisphenol A results in increased methylation of IL18BP promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of IL18BP mRNA	25181051
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of IL18BP mRNA	27339419
D002784	Cholesterol	"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of IL18BP mRNA"	22129739
C480342	clothianidin	clothianidin results in decreased expression of IL18BP mRNA	29044138
D003042	Cocaine	Cocaine affects the expression of IL18BP mRNA	20187946
D003471	Cuprizone	Cuprizone results in increased expression of IL18BP mRNA	26577399
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of IL18BP mRNA	27392435
D004008	Diclofenac	Diclofenac results in increased expression of IL18BP mRNA	26934552
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of IL18BP mRNA	25380136
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IL18BP mRNA	17942748
D005419	Flavonoids	Flavonoids results in increased expression of IL18BP mRNA	18035473
D007213	Indomethacin	Indomethacin results in increased expression of IL18BP mRNA	18996434
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL18BP mRNA	25613284
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of IL18BP mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of IL18BP mRNA	23086925
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IL18BP mRNA]	26582142
D048628	Ketolides	Ketolides analog results in increased expression of IL18BP mRNA	24967691
C008261	lead acetate	lead acetate results in decreased expression of IL18BP mRNA	20542052
C045463	leflunomide	leflunomide results in decreased expression of IL18BP mRNA	28988120
D008070	Lipopolysaccharides	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IL18BP mRNA]	26582142
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IL18BP mRNA	26582142\|2733941
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of IL18BP mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of IL18BP mRNA"	25554681\|2562005
D009532	Nickel	Nickel results in increased expression of IL18BP mRNA	25583101
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of IL18BP mRNA	25729387
D010098	Oxycodone	Oxycodone results in decreased expression of IL18BP mRNA	23439660
C016030	pantogab	pantogab results in increased expression of IL18BP mRNA	17379144
D010634	Phenobarbital	Phenobarbital results in increased expression of IL18BP mRNA	19363144
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IL18BP mRNA	19710929
D010936	Plant Extracts	Plant Extracts results in decreased expression of IL18BP mRNA	23557933
C059514	resveratrol	resveratrol results in increased expression of IL18BP mRNA	25905778
D053260	Soot	Soot results in increased expression of IL18BP mRNA	22461453
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IL18BP mRNA	21570461\|2892240
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IL18BP mRNA	17942748
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL18BP mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in decreased expression of IL18BP mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in increased expression of IL18BP mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of IL18BP mRNA	25729387
D014635	Valproic Acid	Valproic Acid results in increased methylation of IL18BP gene	29154799
C025643	vinclozolin	vinclozolin results in increased expression of IL18BP mRNA	23034163

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0042007	interleukin-18 binding	-	IBA	21873635
GO:0042007	interleukin-18 binding	-	IDA	10023777
GO:0048019	receptor antagonist activity	-	TAS	11890646

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0035655	interleukin-18-mediated signaling pathway	-	TAS	-
GO:0042088	T-helper 1 type immune response	-	IBA	21873635
GO:0042088	T-helper 1 type immune response	-	IDA	10023777
GO:0070301	cellular response to hydrogen peroxide	-	IEA	-
GO:0071345	cellular response to cytokine stimulus	-	TAS	-
GO:0071356	cellular response to tumor necrosis factor	-	IEA	-
GO:1900116	extracellular negative regulation of signal transduction	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	10023777
GO:0005615	extracellular space	-	IBA	21873635
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-168256	Immune System	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-9008059	Interleukin-37 signaling	TAS
R-HSA-9012546	Interleukin-18 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23752598	IL-18 and IL-18 binding protein concentration in ovarian follicular fluid of women with "tubal factor" subjected to in vitro fertilization. (2013 May 21)	Radwan P	Postepy Hig Med Dosw (Online)