Gene info: ID 10079

Gene: ATP9A

GENE ID: 10079

Synonyms: ATPIIA

Description: ATPase phospholipid transporting 9A (putative)

Gene type: protein-coding

Location: 20q13.2

dbXrefs: Ensembl:ENSG00000054793 MIM:609126 Vega:OTTHUMG00000032751 UniprotKB:O75110

RefSeq: NC_000020.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.811e-1 (AD) 9.392e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg07339236	chr20:50312490	ATP9A		8.610e-35	Maternal smoking in pregnancy	27040690
cg07339236	chr20:50312490	ATP9A		1.390e-48	Maternal smoking in pregnancy	27040690
cg07339236	chr20:50312490	ATP9A		5.650e-57	Maternal smoking in pregnancy	27040690
cg07339236	chr20:50312490	ATP9A		2.400e-25	Smoking	27651444
cg21380183	chr20:50312632	ATP9A		3.900e-15	Smoking	27651444
cg07339236	chr20:50312490	ATP9A		3.110e-15	Tobacco smoking	28225026
cg07339236	chr20:50312490	ATP9A		2.910e-27	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ARHGEF9	0.977
PAFAH1B1	0.967
OXCT1	0.967
NDRG3	0.966
DOCK3	0.965
WDR47	0.964
CAMSAP1	0.963
HSPA12A	0.962
FAM20B	0.96
YWHAG	0.959

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.579
OR4F29	-0.553
CSAG1	-0.481
RNF135	-0.454
TFPI2	-0.447
CST7	-0.444
KCNJ15	-0.434
CXCR2	-0.43
CLEC2B	-0.427
MYL3	-0.426

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ATP9A mRNA"	21354444
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ATP9A mRNA	19933214
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ATP9A mRNA"	19167446
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ATP9A mRNA	19770486
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of ATP9A mRNA	21757418
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ATP9A mRNA	16483693
D001554	Benzene	Benzene affects the expression of ATP9A mRNA	15878777
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ATP9A mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ATP9A mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ATP9A mRNA	19770486\|2222880
C044887	beta-methylcholine	beta-methylcholine affects the expression of ATP9A mRNA	21179406
C006780	bisphenol A	bisphenol A results in decreased expression of ATP9A mRNA	22576693
C006780	bisphenol A	bisphenol A results in increased expression of ATP9A mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased methylation of ATP9A gene	22576693
C018475	butyraldehyde	butyraldehyde results in decreased expression of ATP9A mRNA	26079696
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ATP9A mRNA	17484886
D000068579	Celecoxib	Celecoxib affects the expression of ATP9A mRNA	20562220
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ATP9A mRNA"	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of ATP9A mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of ATP9A mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of ATP9A mRNA	20106945
D002945	Cisplatin	Cisplatin results in decreased expression of ATP9A mRNA	24280081
D002945	Cisplatin	Cisplatin affects the expression of ATP9A mRNA	24280081
D004041	Dietary Fats	Dietary Fats results in decreased expression of ATP9A mRNA	21852083
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATP9A mRNA	17942748
D005472	Fluorouracil	ATP9A protein affects the susceptibility to Fluorouracil	15352031
D005472	Fluorouracil	Fluorouracil results in decreased expression of ATP9A protein	15352031
C010974	glyphosate	glyphosate results in increased expression of ATP9A mRNA	17984146
D006534	Heptachlor Epoxide	Heptachlor Epoxide results in decreased expression of ATP9A mRNA	25270620
D017313	Fenretinide	Fenretinide results in decreased expression of ATP9A mRNA	28973697
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ATP9A mRNA	26644586
D007854	Lead	Lead affects the expression of ATP9A mRNA	28903495
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of ATP9A mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of ATP9A mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ATP9A mRNA"	20188158
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP9A mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP9A mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP9A mRNA]"	20230807
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ATP9A mRNA"	25554681
C029938	nickel sulfate	nickel sulfate results in increased expression of ATP9A mRNA	22714537
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP9A mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP9A mRNA]"	20230807
C025589	ochratoxin A	ochratoxin A results in increased expression of ATP9A mRNA	16251485
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
C496932	panobinostat	panobinostat results in decreased expression of ATP9A mRNA	26272509
D010656	Phenylephrine	Phenylephrine results in increased expression of ATP9A mRNA	18158353
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of ATP9A mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ATP9A mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of ATP9A mRNA	18301758\|2381119
D011794	Quercetin	Quercetin results in decreased expression of ATP9A mRNA	21632981
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of ATP9A mRNA	14699072
D013629	Tamoxifen	Tamoxifen affects the expression of ATP9A mRNA	14699072
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ATP9A mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATP9A mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ATP9A mRNA	19933214
D013792	Thalidomide	Thalidomide results in increased expression of ATP9A mRNA	28892372
C009495	titanium dioxide	titanium dioxide results in decreased expression of ATP9A mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased methylation of ATP9A gene	26756918
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of ATP9A mRNA	28065790
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of ATP9A mRNA	24935251\|2627250
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of ATP9A mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of ATP9A mRNA	23179753\|2438349
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP9A mRNA"	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	IEA	-
GO:0004012	phospholipid-translocating ATPase activity	-	IBA	21873635
GO:0005524	ATP binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	IBA	21873635
GO:0006897	endocytosis	-	IBA	21873635
GO:0045332	phospholipid translocation	-	IBA	21873635
GO:0045332	phospholipid translocation	-	NAS	21914794

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005768	endosome	-	IBA	21873635
GO:0005769	early endosome	-	IDA	21914794
GO:0005802	trans-Golgi network	-	IBA	21873635
GO:0005802	trans-Golgi network	-	IDA	21914794
GO:0005886	plasma membrane	-	IBA	21873635
GO:0016021	integral component of membrane	-	IEA	-
GO:0031901	early endosome membrane	-	IEA	-
GO:0048471	perinuclear region of cytoplasm	-	IDA	21914794
GO:0055037	recycling endosome	-	IDA	21914794

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-382551	Transport of small molecules	TAS
R-HSA-936837	Ion transport by P-type ATPases	TAS
R-HSA-983712	Ion channel transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25552657	Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). (2015 Apr 15)	Richmond RC	Hum Mol Genet
24906187	Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy. (2014 Oct)	Markunas CA	Environ Health Perspect