Gene info: ID 1008

Gene: CDH10

GENE ID: 1008

Synonyms: -

Description: cadherin 10

Gene type: protein-coding

Location: 5p14.2-p14.1

dbXrefs: Ensembl:ENSG00000040731 MIM:604555 Vega:OTTHUMG00000090667 UniprotKB:Q9Y6N8

RefSeq: NC_000005.10

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.675e-3 (AD) 8.023e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs3797173	chr5:24497138 (GRCh38.p7)	A>C / A>G / A>T	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FAM217B	0.94
THRB	0.939
PPM1L	0.939
GRIA2	0.938
NRXN1	0.938
AMIGO1	0.938
MYH10	0.937
RAB6B	0.935
MAPK10	0.935
EFR3A	0.932

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TFPI2	-0.573
ARHGEF5	-0.512
WWTR1	-0.504
CMTM3	-0.504
RAI14	-0.493
HEY2	-0.491
KLRB1	-0.487
OR4F5	-0.482
ACAP1	-0.482
IL18RAP	-0.478

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CDH10 mRNA"	27291303
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH10 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH10 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH10 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH10 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH10 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH10 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH10 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH10 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of CDH10 mRNA	29067470
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CDH10 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CDH10 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CDH10 mRNA	16483693
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with fluoranthene] results in increased expression of CDH10 mRNA	25412620
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CDH10 mRNA	20106945\|2231617
C006780	bisphenol A	bisphenol A affects the expression of CDH10 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of CDH10 mRNA	25181051
D003471	Cuprizone	Cuprizone results in decreased expression of CDH10 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in increased expression of CDH10 mRNA	20106945
D002945	Cisplatin	Cisplatin results in increased expression of CDH10 mRNA	27392435
D005419	Flavonoids	Flavonoids results in increased expression of CDH10 mRNA	18035473
C007738	fluoranthene	[Benzo(a)pyrene co-treated with fluoranthene] results in increased expression of CDH10 mRNA	25412620
C018091	maduramicin	maduramicin results in increased expression of CDH10 mRNA	29128925
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CDH10 mRNA	26378955
C042720	mercuric bromide	mercuric bromide results in increased expression of CDH10 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH10 mRNA"	27188386
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of CDH10 mRNA	28001369
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of CDH10 mRNA	24810058
C523799	MRK 003	CDH10 results in decreased susceptibility to MRK 003	19903844
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH10 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of CDH10 mRNA	26272509
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH10 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of CDH10 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in increased expression of CDH10 mRNA	20813756
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of CDH10 mRNA	22714537
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CDH10 mRNA	24780913
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of CDH10 mRNA	25895662
D012999	Soman	Soman results in decreased expression of CDH10 mRNA	19281266
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CDH10 mRNA	26378955
D013792	Thalidomide	Thalidomide results in decreased expression of CDH10 mRNA	26217789
D014212	Tretinoin	Tretinoin results in decreased expression of CDH10 mRNA	21934132
C012589	trichostatin A	trichostatin A results in increased expression of CDH10 mRNA	24935251
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CDH10 mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in increased expression of CDH10 mRNA	17127020
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH10 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of CDH10 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of CDH10 mRNA	23179753\|2519280
D014635	Valproic Acid	Valproic Acid results in decreased methylation of CDH10 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of CDH10 mRNA	23179753\|2438349
D014638	Vanadates	Vanadates results in increased expression of CDH10 mRNA	22714537
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CDH10 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005509	calcium ion binding	-	IBA	21873635
GO:0005509	calcium ion binding	-	IEA	-
GO:0008092	cytoskeletal protein binding	-	IBA	21873635
GO:0042803	protein homodimerization activity	-	IBA	21873635
GO:0045296	cadherin binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000902	cell morphogenesis	-	IBA	21873635
GO:0007043	cell-cell junction assembly	-	IBA	21873635
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	-	IBA	21873635
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	-	IEA	-
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	-	IBA	21873635
GO:0034332	adherens junction organization	-	IBA	21873635
GO:0034332	adherens junction organization	-	TAS	-
GO:0044331	cell-cell adhesion mediated by cadherin	-	IBA	21873635
GO:0098609	cell-cell adhesion	-	NAS	10861224

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0005913	cell-cell adherens junction	-	IBA	21873635
GO:0009986	cell surface	-	IBA	21873635
GO:0016021	integral component of membrane	-	IEA	-
GO:0016342	catenin complex	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1500931	Cell-Cell communication	TAS
R-HSA-418990	Adherens junctions interactions	TAS
R-HSA-421270	Cell-cell junction organization	TAS
R-HSA-446728	Cell junction organization	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal