Gene: GPC6

10082
OMIMD1
glypican 6
protein-coding
13q31.3-q32.1
Ensembl:ENSG00000183098 MIM:604404 Vega:OTTHUMG00000017205 UniprotKB:Q9Y625
NG_011880.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.775e-1 (AD)  5.587e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9556369chr13:94399306 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18652327chr13:94500648GPC6Gene body5.352e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNGA30.643
PDGFD0.632
DSG20.616
ITGA40.603
EXPH50.603
PRELID20.582
DYRK20.575
NPNT0.573
ZBTB8A0.571
PHACTR20.568

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FXYD3-0.324
SEPT12-0.273
KIF19-0.273
HPN-0.251
PLIN4-0.25
MYBPHL-0.246
ARMC12-0.244
CLDN9-0.241
OTOS-0.234
DRD4-0.233

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GPC6 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GPC6 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GPC6 mRNA21641981|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GPC6 gene27153756
D001151ArsenicArsenic affects the methylation of GPC6 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of GPC6 mRNA25258189
C015001arsenitearsenite results in decreased expression of GPC6 mRNA23974009
D001280AtrazineAtrazine results in increased expression of GPC6 mRNA22378314
C487081belinostatbelinostat results in decreased expression of GPC6 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GPC6 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GPC6 mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of GPC6 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GPC6 mRNA"26238291
C006780bisphenol Abisphenol A results in increased expression of GPC6 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of GPC6 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of GPC6 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of GPC6 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GPC6 mRNA17484886
D003471CuprizoneCuprizone results in increased expression of GPC6 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of GPC6 mRNA20106945|2556210
C014347decitabinedecitabine affects the expression of GPC6 mRNA23300844
D003907DexamethasoneDexamethasone results in decreased expression of GPC6 mRNA25047013
D002945CisplatinCisplatin affects the expression of GPC6 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GPC6 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GPC6 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of GPC6 mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GPC6 mRNA24535843
D002117CalcitriolCalcitriol results in increased expression of GPC6 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of GPC6 mRNA21592394
C118739entinostatentinostat results in decreased expression of GPC6 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GPC6 mRNA27392435
D007854LeadLead affects the expression of GPC6 mRNA28903495
C045463leflunomideleflunomide results in increased expression of GPC6 mRNA28988120
D008353MannitolMannitol results in increased expression of GPC6 mRNA25270620
D009532NickelNickel results in decreased expression of GPC6 mRNA25583101
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of GPC6 mRNA26272509
D010634PhenobarbitalPhenobarbital affects the expression of GPC6 mRNA23091169
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GPC6 mRNA22714537
D011794QuercetinQuercetin results in decreased expression of GPC6 mRNA21632981
C059514resveratrolresveratrol results in decreased expression of GPC6 mRNA25888808
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GPC6 mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of GPC6 mRNA21795629
D012969Sodium FluorideSodium Fluoride results in increased expression of GPC6 mRNA27862939
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of GPC6 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of GPC6 mRNA21592394
D014212TretinoinTretinoin results in increased expression of GPC6 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of GPC6 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPC6 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GPC6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GPC6 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI29162697  
GO:1904929coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway-NAS24431302  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0006024glycosaminoglycan biosynthetic process-TAS-  
GO:0006027glycosaminoglycan catabolic process-TAS-  
GO:0009966regulation of signal transduction-IEA-  
GO:0016477cell migration-IDA21871017  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005634nucleus-HDA21630459  
GO:0005796Golgi lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0043202lysosomal lumen-TAS-  
GO:0046658anchored component of plasma membrane-IEA-  
GO:0062023collagen-containing extracellular matrix-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismIEA
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismTAS
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismIEA
R-HSA-1643685DiseaseTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-1971475A tetrasaccharide linker sequence is required for GAG synthesisTAS
R-HSA-2022928HS-GAG biosynthesisTAS
R-HSA-2022928HS-GAG biosynthesisIEA
R-HSA-2024096HS-GAG degradationTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-3560782Diseases associated with glycosaminoglycan metabolismTAS
R-HSA-3560783Defective B4GALT7 causes EDS, progeroid typeTAS
R-HSA-3560801Defective B3GAT3 causes JDSSDHDTAS
R-HSA-3656237Defective EXT2 causes exostoses 2TAS
R-HSA-3656253Defective EXT1 causes exostoses 1, TRPS2 and CHDSTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-4420332Defective B3GALT6 causes EDSP2 and SEMDJL1TAS
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-71387Metabolism of carbohydratesIEA
R-HSA-975634Retinoid metabolism and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal