Gene: USH1C

10083
AIE-75|DFNB18|DFNB18A|NY-CO-37|NY-CO-38|PDZ-45|PDZ-73|PDZ-73/NY-CO-38|PDZ73|PDZD7C|ush1cpst
USH1 protein network component harmonin
protein-coding
11p15.1
Ensembl:ENSG00000006611 MIM:605242 Vega:OTTHUMG00000166323 UniprotKB:Q9Y6N9
NG_011883.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.223e-1 (AD)  2.290e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRR5L0.725
BTBD160.711
HMSD0.702
C2orf880.701
PPP1R14A0.7
TJP20.691
TPPP30.685
SMIM60.684
TMCC30.68
KIF60.674

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADRB1-0.391
RORB-0.369
MGAT5B-0.364
CUX2-0.355
CA7-0.35
RARB-0.347
RASD2-0.345
SCRT2-0.345
KCNK12-0.342
SHROOM3-0.342

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of USH1C mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of USH1C mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of USH1C mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of USH1C mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of USH1C mRNA"25510870
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of USH1C mRNA21298039
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of USH1C mRNA21298039
C006780bisphenol Abisphenol A results in decreased expression of USH1C mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of USH1C mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of USH1C mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of USH1C gene28505145
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of USH1C mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of USH1C mRNA19376846
D003471CuprizoneCuprizone results in increased expression of USH1C mRNA26577399
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of USH1C mRNA27392435
D002945CisplatinCisplatin results in increased expression of USH1C mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of USH1C mRNA28302478
C118739entinostatentinostat results in increased expression of USH1C mRNA27188386
C039281furanfuran results in increased expression of USH1C mRNA27387713
D017313FenretinideFenretinide results in increased expression of USH1C mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of USH1C mRNA21396975
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of USH1C mRNA27392435
D008694MethamphetamineMethamphetamine results in increased expression of USH1C mRNA26307267
D008727MethotrexateUSH1C protein affects the susceptibility to Methotrexate16217747
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of USH1C mRNA22401849
C500085muraglitazarmuraglitazar results in decreased expression of USH1C mRNA21515302
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of USH1C mRNA"25510870
D011192Potassium DichromatePotassium Dichromate results in decreased expression of USH1C mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of USH1C mRNA19690047
C089730rosiglitazonerosiglitazone results in decreased expression of USH1C mRNA21515302
C079198S 1 (combination)USH1C protein results in increased susceptibility to S 1 (combination)16734730
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of USH1C mRNA25895662
D012834SilverSilver results in increased expression of USH1C mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of USH1C gene28589171
C016104sodium bichromatesodium bichromate results in decreased expression of USH1C mRNA24612858
C501413tesaglitazartesaglitazar results in decreased expression of USH1C mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of USH1C mRNA22298810
C012589trichostatin Atrichostatin A results in increased expression of USH1C mRNA28542535
C057693troglitazonetroglitazone results in decreased expression of USH1C mRNA21515302
D014635Valproic AcidValproic Acid affects the expression of USH1C mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of USH1C mRNA29154799
D024483Vitamin K 3Vitamin K 3 affects the expression of USH1C mRNA20044591
D015032ZincZinc results in decreased expression of USH1C mRNA15984569

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11311560  12588794  16301216  16464467  20142502  24725409  
25416956  26812018  27173435  
GO:0030507spectrin binding-IDA23704327  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-IMP15219944  
GO:0007605sensory perception of sound-IBA21873635  
GO:0007605sensory perception of sound-IMP11398101  
GO:0030046parallel actin filament bundle assembly-ISS-  
GO:0032532regulation of microvillus length-ISS-  
GO:0034622cellular protein-containing complex assembly-IDA26812018  
GO:0042472inner ear morphogenesis-IBA21873635  
GO:0042472inner ear morphogenesis-ISS-  
GO:0042491inner ear auditory receptor cell differentiation-IBA21873635  
GO:0042491inner ear auditory receptor cell differentiation-ISS-  
GO:0045494photoreceptor cell maintenance-IMP11398101  
GO:0046549retinal cone cell development-IBA21873635  
GO:0050953sensory perception of light stimulus-IBA21873635  
GO:0050953sensory perception of light stimulus-IMP11398101  
GO:0050957equilibrioception-IMP10973247  
GO:0051017actin filament bundle assembly-ISS-  
GO:0060119inner ear receptor cell development-IBA21873635  
GO:0060122inner ear receptor cell stereocilium organization-IBA21873635  
GO:0060122inner ear receptor cell stereocilium organization-ISS-  
GO:1904106protein localization to microvillus-IMP24725409  26812018  
GO:1904106protein localization to microvillus-ISS-  
GO:1904970brush border assembly-IBA21873635  
GO:1904970brush border assembly-IMP24725409  
GO:1904970brush border assembly-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-ISS-  
GO:0001917photoreceptor inner segmentCOLOCALIZES_WITHIBA21873635  
GO:0001917photoreceptor inner segment-ISS-  
GO:0002141stereocilia ankle link-IBA21873635  
GO:0002142stereocilia ankle link complex-IBA21873635  
GO:0005737cytoplasm-IDA10209257  
GO:0005829cytosol-IDA-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-ISS-  
GO:0005902microvillus-IDA24725409  
GO:0005903brush border-IDA21330445  24725409  
GO:0032391photoreceptor connecting ciliumCOLOCALIZES_WITHIBA21873635  
GO:0032420stereocilium-IBA21873635  
GO:0032420stereocilium-ISS-  
GO:0032420stereocilium-TAS16464467  
GO:0032426stereocilium tip-IBA21873635  
GO:0045177apical part of cell-IDA10209257  
GO:0045202synapse-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23665419Prenatal smoke exposure: effects on infant auditory system and placental gene expression. (2013 Jul-Aug)Katbamna BNeurotoxicol Teratol