Gene: EDIL3

10085
DEL1
EGF like repeats and discoidin domains 3
protein-coding
5q14.3
Ensembl:ENSG00000164176 MIM:606018 Vega:OTTHUMG00000119047 UniprotKB:O43854
NC_000005.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.940e-2 (AD)  6.417e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs153248chr5:84174097 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPOCK30.887
ABHD17B0.879
CCP1100.877
DIP2B0.873
LRRC8D0.872
CFL20.87
SLC12A20.87
ALCAM0.867
RNF130.865
ATG4C0.864

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.523
OR4F29-0.514
RNF43-0.287
WNT7B-0.276
HKDC1-0.273
GLI2-0.27
KCNK5-0.261
PPP1R3G-0.259
SIX5-0.253
EYA2-0.252

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of EDIL3 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDIL3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDIL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDIL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDIL3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of EDIL3 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EDIL3 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EDIL3 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EDIL3 mRNA24449571
C547126AZM551248AZM551248 results in increased expression of EDIL3 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of EDIL3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EDIL3 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EDIL3 mRNA17879257|2231617
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of EDIL3 mRNA15336504
C018021cobaltous chloridecobaltous chloride results in decreased expression of EDIL3 mRNA19320972
D003300Copper[Disulfiram binds to Copper] which results in increased expression of EDIL3 mRNA24690739
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of EDIL3 mRNA"19167446
D003474CurcuminCurcumin results in decreased expression of EDIL3 mRNA18421014
D000069439DasatinibDasatinib results in increased expression of EDIL3 mRNA20579391
D004008DiclofenacDiclofenac results in decreased expression of EDIL3 mRNA26934552
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of EDIL3 mRNA24690739
D005472FluorouracilEDIL3 protein affects the susceptibility to Fluorouracil16217747
D005557FormaldehydeFormaldehyde results in increased expression of EDIL3 mRNA28937961
C001277geldanamycingeldanamycin results in increased expression of EDIL3 mRNA26705709
D007854LeadLead affects the expression of EDIL3 mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of EDIL3 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of EDIL3 mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EDIL3 mRNA23103053
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of EDIL3 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EDIL3 mRNA"24389112
D009532NickelNickel results in decreased expression of EDIL3 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of EDIL3 mRNA22714537
C025256nonylphenolnonylphenol results in decreased expression of EDIL3 mRNA22982499
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDIL3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of EDIL3 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in increased expression of EDIL3 protein23718831
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of EDIL3 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of EDIL3 mRNA26378955
D013629TamoxifenTamoxifen affects the expression of EDIL3 mRNA14699072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EDIL3 mRNA21570461
C009495titanium dioxidetitanium dioxide results in decreased expression of EDIL3 mRNA23557971
D014212TretinoinTretinoin results in increased expression of EDIL3 mRNA21934132
D014403TubocurarineTubocurarine results in decreased expression of EDIL3 mRNA19728367
D014415TunicamycinTunicamycin results in increased expression of EDIL3 mRNA17127020
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDIL3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of EDIL3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of EDIL3 mRNA19101580|2317975
D014638VanadatesVanadates results in increased expression of EDIL3 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EDIL3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-IEA-  
GO:0005509calcium ion binding-IEA-  
GO:0070492oligosaccharide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0010811positive regulation of cell-substrate adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0062023collagen-containing extracellular matrix-HDA23979707  27068509  
GO:0070062extracellular exosome-HDA21362503  
GO:1903561extracellular vesicle-HDA24769233  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal